CDK5 and CDK5R1

Number of citations of the paper that reports this interaction (PMID 11583627)
28

Data Source:
HPRD (in vivo, in vitro)

		CDK5	CDK5R1
Gene Name		cyclin-dependent kinase 5	cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Postsynaptic Density Membrane Cyclin-dependent Protein Kinase 5 Holoenzyme Complex Lamellipodium Cell Junction Filopodium Axon Dendrite Growth Cone Neuromuscular Junction Neuronal Cell Body Perikaryon Postsynaptic Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Cyclin-dependent Protein Kinase 5 Holoenzyme Complex Axon Dendrite Growth Cone Neuromuscular Junction Neuronal Cell Body Dendritic Spine Intracellular Membrane-bounded Organelle Contractile Fiber Perinuclear Region Of Cytoplasm
	Molecular Function	P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity ErbB-2 Class Receptor Binding Protein Binding ATP Binding Cytoskeletal Protein Binding Kinase Activity Acetylcholine Receptor Activator Activity ErbB-3 Class Receptor Binding Ephrin Receptor Binding Tau-protein Kinase Activity	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Calcium Ion Binding Protein Binding Kinase Activity Cyclin-dependent Protein Kinase 5 Activator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity Cadherin Binding Ephrin Receptor Binding
	Biological Process	Neuron Migration Synaptic Transmission, Dopaminergic Intracellular Protein Transport Nucleocytoplasmic Transport Cell Cycle Cell-matrix Adhesion Synaptic Transmission Axon Guidance Synapse Assembly Skeletal Muscle Tissue Development Blood Coagulation Motor Neuron Axon Guidance Cell Proliferation Visual Learning Embryo Development Schwann Cell Development Synaptic Vesicle Exocytosis Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Sensory Perception Of Pain Cerebellar Cortex Formation Hippocampus Development Layer Formation In Cerebral Cortex Central Nervous System Neuron Development Corpus Callosum Development Neuron Differentiation Regulation Of Cell Migration Negative Regulation Of Axon Extension Cortical Actin Cytoskeleton Organization Neuron Projection Development Negative Regulation Of Protein Ubiquitination Negative Regulation Of Synaptic Plasticity Positive Regulation Of Protein Binding Receptor Catabolic Process Serine Phosphorylation Of STAT3 Protein Synaptic Transmission, Glutamatergic Protein Localization To Synapse Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Regulated Secretory Pathway Negative Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Calcium Ion-dependent Exocytosis Protein Autophosphorylation Negative Regulation Of Protein Export From Nucleus Behavioral Response To Cocaine Regulation Of Synaptic Plasticity Synaptic Vesicle Endocytosis Rhythmic Process Axon Extension Oligodendrocyte Differentiation Dendrite Morphogenesis Cell Division Neuron Apoptotic Process Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Dendritic Spine Morphogenesis Calcium Ion Import Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Neuron Death Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Receptor Activity	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Neuron Migration Neuron Cell-cell Adhesion G-protein Coupled Acetylcholine Receptor Signaling Pathway Axon Guidance Axonal Fasciculation Brain Development Cell Proliferation Embryo Development Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebellum Development Superior Olivary Nucleus Maturation Hippocampus Development Layer Formation In Cerebral Cortex Neuron Differentiation Negative Regulation Of Axon Extension Neuron Projection Development Regulation Of Actin Cytoskeleton Organization Serine Phosphorylation Of STAT3 Protein Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Ephrin Receptor Signaling Pathway Rhythmic Process Regulation Of Dendritic Spine Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Targeting To Membrane
Pathways		Signaling by GPCR Axon guidance Semaphorin interactions Opioid Signalling DARPP-32 events CRMPs in Sema3A signaling Factors involved in megakaryocyte development and platelet production	Axon guidance Semaphorin interactions CRMPs in Sema3A signaling
Drugs		Indirubin-3\'-Monoxime Olomoucine Hymenialdisine SU9516 Flavopiridol Alsterpaullone 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases
GWAS
Protein-Protein Interactions		68 interactors: ABL1 ACTN1 ALAS1 AMPH APP BAG6 BRCA1 C1orf61 CABLES1 CABLES2 CCND2 CCNG1 CDC37 CDK16 CDK5R1 CDK5R2 CDK5RAP1 CDK5RAP2 CDKN1B CHN1 CSNK1D DAB1 DCX DNM1 ERBB3 EZR FSD1 FYN GAK GRIN2A GSK3B H1F0 HIST1H1B HTRA2 KIF26B LMTK2 MAP2K1 MAPK10 MAPT MAST1 MBP MEF2A NDEL1 NEDD4 NEDD4L NES PAK1 PARK2 PCNA PIP5K1C PPARG PPP1R1B PPP1R2 PSEN1 PTPN2 PURA RB1 RNF32 RPL34 SET SRC STX1A STXBP1 SYN1 SYNJ1 TLN1 TP53 WASF1	31 interactors: ACTN1 AMPH APP BLOC1S6 CAMK2A CAPN1 CAPN2 CDK16 CDK5 CDK5RAP1 CDK5RAP2 CDK5RAP3 CDK9 CHN1 CTNNB1 HSP90AA1 KRT40 KRTAP10-3 LMTK2 MAPT MTUS2 NEDD4 NES NOTCH2NL ODF1 PAK1 SET SIAH1 STXBP1 TSC22D4 TTBK1
Entrez ID		1020	8851
HPRD ID		00449	04586
Ensembl ID			ENSG00000176749
Uniprot IDs		Q00535	Q15078 Q8N619
PDB IDs		1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8	1H4L 1UNG 1UNH 1UNL 3O0G
Enriched GO Terms of Interacting Partners?		Nervous System Development Neurogenesis Regulation Of Cellular Component Organization Generation Of Neurons Regulation Of Protein Metabolic Process System Development Neuron Development Neuron Projection Development Multicellular Organismal Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Differentiation Regulation Of Cellular Protein Metabolic Process Anatomical Structure Development Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Cell Projection Organization Regulation Of Catalytic Activity Cell Differentiation Cell Morphogenesis Involved In Differentiation Axonogenesis Neuron Projection Morphogenesis Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Developmental Process Brain Development Positive Regulation Of Cellular Protein Metabolic Process Axon Development Head Development Cellular Localization Regulation Of Organelle Organization Regulation Of Phosphorylation Cell Projection Morphogenesis Regulation Of Signaling Cell Development Central Nervous System Development Cell Part Morphogenesis Organelle Organization Locomotion Axon Guidance Cell Morphogenesis Anatomical Structure Morphogenesis Movement Of Cell Or Subcellular Component Cell Cycle Organelle Localization Regulation Of Neuron Death Regulation Of Cellular Localization Signaling Positive Regulation Of Protein Modification Process Regulation Of Metabolic Process	Generation Of Neurons Nervous System Development Neurogenesis Establishment Of Localization In Cell Neuron Projection Development Cellular Localization Neuron Differentiation Cell Differentiation Cell Projection Organization Neuron Development Multicellular Organismal Development Vesicle-mediated Transport Regulation Of Organelle Organization Regulation Of Neurogenesis Establishment Of Organelle Localization Regulation Of Cellular Component Organization Developmental Process Cell Morphogenesis Involved In Differentiation Exocytosis Axonogenesis Synaptic Vesicle Transport Regulation Of Neuron Differentiation Cell Morphogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Morphogenesis Cell Development Regulation Of Cell Development System Development Cell Part Morphogenesis Organelle Localization Neuron Projection Morphogenesis Receptor Catabolic Process Anatomical Structure Development Synapse Organization Regulation Of Cytoskeleton Organization Secretion By Cell Brain Development Receptor Metabolic Process Response To Abiotic Stimulus Head Development Establishment Of Vesicle Localization Negative Regulation Of Neuron Death Vesicle Localization Axon Guidance Regulation Of Cell Differentiation Secretion Anatomical Structure Morphogenesis Regulation Of Cell Cycle Locomotion
Tagcloud ?		accelerates antisense axonal besides cerebellar collectively cones constituents cytoskeleton designated elongation epitope extension isoform laminin linker machinery macroneurons map1b oligonucleotide p35 p39 proline redistribution reduces selectively stimulates subcellular subcortical	10a 200c 30a 30c arhgap5 cd36 cdh2 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3
Tagcloud (Difference) ?		accelerates antisense axonal besides cerebellar collectively cones constituents cytoskeleton designated elongation epitope extension isoform laminin linker machinery macroneurons map1b oligonucleotide p35 p39 proline redistribution reduces selectively stimulates subcellular subcortical	10a 200c 30a 30c arhgap5 cd36 cdh2 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3
Tagcloud (Intersection) ?