CDK5 and KIF26B

Number of citations of the paper that reports this interaction (PMID 22768111)
0

Data Source:
BioGRID (enzymatic study)

		CDK5	KIF26B
Gene Name		cyclin-dependent kinase 5	kinesin family member 26B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Postsynaptic Density Membrane Cyclin-dependent Protein Kinase 5 Holoenzyme Complex Lamellipodium Cell Junction Filopodium Axon Dendrite Growth Cone Neuromuscular Junction Neuronal Cell Body Perikaryon Postsynaptic Membrane	Cytoplasm Kinesin Complex Microtubule
	Molecular Function	P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity ErbB-2 Class Receptor Binding Protein Binding ATP Binding Cytoskeletal Protein Binding Kinase Activity Acetylcholine Receptor Activator Activity ErbB-3 Class Receptor Binding Ephrin Receptor Binding Tau-protein Kinase Activity	Microtubule Motor Activity ATP Binding Microtubule Binding ATPase Activity
	Biological Process	Neuron Migration Synaptic Transmission, Dopaminergic Intracellular Protein Transport Nucleocytoplasmic Transport Cell Cycle Cell-matrix Adhesion Synaptic Transmission Axon Guidance Synapse Assembly Skeletal Muscle Tissue Development Blood Coagulation Motor Neuron Axon Guidance Cell Proliferation Visual Learning Embryo Development Schwann Cell Development Synaptic Vesicle Exocytosis Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Sensory Perception Of Pain Cerebellar Cortex Formation Hippocampus Development Layer Formation In Cerebral Cortex Central Nervous System Neuron Development Corpus Callosum Development Neuron Differentiation Regulation Of Cell Migration Negative Regulation Of Axon Extension Cortical Actin Cytoskeleton Organization Neuron Projection Development Negative Regulation Of Protein Ubiquitination Negative Regulation Of Synaptic Plasticity Positive Regulation Of Protein Binding Receptor Catabolic Process Serine Phosphorylation Of STAT3 Protein Synaptic Transmission, Glutamatergic Protein Localization To Synapse Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Regulated Secretory Pathway Negative Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Calcium Ion-dependent Exocytosis Protein Autophosphorylation Negative Regulation Of Protein Export From Nucleus Behavioral Response To Cocaine Regulation Of Synaptic Plasticity Synaptic Vesicle Endocytosis Rhythmic Process Axon Extension Oligodendrocyte Differentiation Dendrite Morphogenesis Cell Division Neuron Apoptotic Process Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Dendritic Spine Morphogenesis Calcium Ion Import Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Neuron Death Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Receptor Activity	Microtubule-based Movement Metabolic Process Positive Regulation Of Cell-cell Adhesion Establishment Of Cell Polarity Ureteric Bud Invasion
Pathways		Signaling by GPCR Axon guidance Semaphorin interactions Opioid Signalling DARPP-32 events CRMPs in Sema3A signaling Factors involved in megakaryocyte development and platelet production
Drugs		Indirubin-3\'-Monoxime Olomoucine Hymenialdisine SU9516 Flavopiridol Alsterpaullone 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases
GWAS			Schizophrenia ( 23212062)
Protein-Protein Interactions		68 interactors: ABL1 ACTN1 ALAS1 AMPH APP BAG6 BRCA1 C1orf61 CABLES1 CABLES2 CCND2 CCNG1 CDC37 CDK16 CDK5R1 CDK5R2 CDK5RAP1 CDK5RAP2 CDKN1B CHN1 CSNK1D DAB1 DCX DNM1 ERBB3 EZR FSD1 FYN GAK GRIN2A GSK3B H1F0 HIST1H1B HTRA2 KIF26B LMTK2 MAP2K1 MAPK10 MAPT MAST1 MBP MEF2A NDEL1 NEDD4 NEDD4L NES PAK1 PARK2 PCNA PIP5K1C PPARG PPP1R1B PPP1R2 PSEN1 PTPN2 PURA RB1 RNF32 RPL34 SET SRC STX1A STXBP1 SYN1 SYNJ1 TLN1 TP53 WASF1	6 interactors: CDK1 CDK2 CDK5 CDK6 MAP4K4 TRAF2
Entrez ID		1020	55083
HPRD ID		00449	13332
Ensembl ID			ENSG00000162849
Uniprot IDs		Q00535	Q2KJY2
PDB IDs		1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8
Enriched GO Terms of Interacting Partners?		Nervous System Development Neurogenesis Regulation Of Cellular Component Organization Generation Of Neurons Regulation Of Protein Metabolic Process System Development Neuron Development Neuron Projection Development Multicellular Organismal Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Differentiation Regulation Of Cellular Protein Metabolic Process Anatomical Structure Development Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Cell Projection Organization Regulation Of Catalytic Activity Cell Differentiation Cell Morphogenesis Involved In Differentiation Axonogenesis Neuron Projection Morphogenesis Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Developmental Process Brain Development Positive Regulation Of Cellular Protein Metabolic Process Axon Development Head Development Cellular Localization Regulation Of Organelle Organization Regulation Of Phosphorylation Cell Projection Morphogenesis Regulation Of Signaling Cell Development Central Nervous System Development Cell Part Morphogenesis Organelle Organization Locomotion Axon Guidance Cell Morphogenesis Anatomical Structure Morphogenesis Movement Of Cell Or Subcellular Component Cell Cycle Organelle Localization Regulation Of Neuron Death Regulation Of Cellular Localization Signaling Positive Regulation Of Protein Modification Process Regulation Of Metabolic Process	Cellular Response To Reactive Oxygen Species Cell Division Negative Regulation Of Cell Cycle Cellular Response To Nitric Oxide Protein Phosphorylation Response To Nitric Oxide G1/S Transition Of Mitotic Cell Cycle Cellular Protein Modification Process Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Response To Reactive Oxygen Species Cellular Response To Reactive Nitrogen Species Cellular Response To Oxidative Stress Regulation Of Protein Ubiquitination Phosphorylation Regulation Of Protein Localization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Cellular Protein Metabolic Process Histone Phosphorylation Regulation Of Cellular Localization Regulation Of Catalytic Activity Peptidyl-threonine Phosphorylation Centrosome Cycle TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Response To Oxidative Stress Positive Regulation Of DNA Replication Positive Regulation Of Protein Binding MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Phosphorylation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Hippocampus Development Phosphate-containing Compound Metabolic Process Positive Regulation Of Protein Kinase Activity Cell Cycle Response To Inorganic Substance Positive Regulation Of Kinase Activity Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Signaling Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Phosphorus Metabolic Process Cell Communication Mitotic DNA Damage Checkpoint Positive Regulation Of Transferase Activity Cell Dedifferentiation Pronuclear Fusion
Tagcloud ?		accelerates antisense axonal besides cerebellar collectively cones constituents cytoskeleton designated elongation epitope extension isoform laminin linker machinery macroneurons map1b oligonucleotide p35 p39 proline redistribution reduces selectively stimulates subcellular subcortical	adenomatous arhgap causative cntn6 cnv cnvs ctnnb1 etiologically filtered focad german germline hsph1 kiaa1797 mcm3ap mining mutyh ngs nonrecurrent polyposis predispose predisposition prioritized silico stringent truncating uncover unexplained ybey
Tagcloud (Difference) ?		accelerates antisense axonal besides cerebellar collectively cones constituents cytoskeleton designated elongation epitope extension isoform laminin linker machinery macroneurons map1b oligonucleotide p35 p39 proline redistribution reduces selectively stimulates subcellular subcortical	adenomatous arhgap causative cntn6 cnv cnvs ctnnb1 etiologically filtered focad german germline hsph1 kiaa1797 mcm3ap mining mutyh ngs nonrecurrent polyposis predispose predisposition prioritized silico stringent truncating uncover unexplained ybey
Tagcloud (Intersection) ?