CDK5 and NES

Number of citations of the paper that reports this interaction (PMID 17036052)
31

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		CDK5	NES
Gene Name		cyclin-dependent kinase 5	nestin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Postsynaptic Density Membrane Cyclin-dependent Protein Kinase 5 Holoenzyme Complex Lamellipodium Cell Junction Filopodium Axon Dendrite Growth Cone Neuromuscular Junction Neuronal Cell Body Perikaryon Postsynaptic Membrane	Cytoplasm Intermediate Filament Intermediate Filament Cytoskeleton
	Molecular Function	P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity ErbB-2 Class Receptor Binding Protein Binding ATP Binding Cytoskeletal Protein Binding Kinase Activity Acetylcholine Receptor Activator Activity ErbB-3 Class Receptor Binding Ephrin Receptor Binding Tau-protein Kinase Activity	Molecular_function Structural Molecule Activity Intermediate Filament Binding
	Biological Process	Neuron Migration Synaptic Transmission, Dopaminergic Intracellular Protein Transport Nucleocytoplasmic Transport Cell Cycle Cell-matrix Adhesion Synaptic Transmission Axon Guidance Synapse Assembly Skeletal Muscle Tissue Development Blood Coagulation Motor Neuron Axon Guidance Cell Proliferation Visual Learning Embryo Development Schwann Cell Development Synaptic Vesicle Exocytosis Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Sensory Perception Of Pain Cerebellar Cortex Formation Hippocampus Development Layer Formation In Cerebral Cortex Central Nervous System Neuron Development Corpus Callosum Development Neuron Differentiation Regulation Of Cell Migration Negative Regulation Of Axon Extension Cortical Actin Cytoskeleton Organization Neuron Projection Development Negative Regulation Of Protein Ubiquitination Negative Regulation Of Synaptic Plasticity Positive Regulation Of Protein Binding Receptor Catabolic Process Serine Phosphorylation Of STAT3 Protein Synaptic Transmission, Glutamatergic Protein Localization To Synapse Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Regulated Secretory Pathway Negative Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Calcium Ion-dependent Exocytosis Protein Autophosphorylation Negative Regulation Of Protein Export From Nucleus Behavioral Response To Cocaine Regulation Of Synaptic Plasticity Synaptic Vesicle Endocytosis Rhythmic Process Axon Extension Oligodendrocyte Differentiation Dendrite Morphogenesis Cell Division Neuron Apoptotic Process Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Dendritic Spine Morphogenesis Calcium Ion Import Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Neuron Death Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Receptor Activity	G2/M Transition Of Mitotic Cell Cycle Central Nervous System Development Brain Development Positive Regulation Of Intermediate Filament Depolymerization Embryonic Camera-type Eye Development Negative Regulation Of Protein Binding Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Cell Projection Morphogenesis Stem Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		Signaling by GPCR Axon guidance Semaphorin interactions Opioid Signalling DARPP-32 events CRMPs in Sema3A signaling Factors involved in megakaryocyte development and platelet production
Drugs		Indirubin-3\'-Monoxime Olomoucine Hymenialdisine SU9516 Flavopiridol Alsterpaullone 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases
GWAS
Protein-Protein Interactions		68 interactors: ABL1 ACTN1 ALAS1 AMPH APP BAG6 BRCA1 C1orf61 CABLES1 CABLES2 CCND2 CCNG1 CDC37 CDK16 CDK5R1 CDK5R2 CDK5RAP1 CDK5RAP2 CDKN1B CHN1 CSNK1D DAB1 DCX DNM1 ERBB3 EZR FSD1 FYN GAK GRIN2A GSK3B H1F0 HIST1H1B HTRA2 KIF26B LMTK2 MAP2K1 MAPK10 MAPT MAST1 MBP MEF2A NDEL1 NEDD4 NEDD4L NES PAK1 PARK2 PCNA PIP5K1C PPARG PPP1R1B PPP1R2 PSEN1 PTPN2 PURA RB1 RNF32 RPL34 SET SRC STX1A STXBP1 SYN1 SYNJ1 TLN1 TP53 WASF1	4 interactors: CDK1 CDK5 CDK5R1 IDE
Entrez ID		1020	10763
HPRD ID		00449	09020
Ensembl ID			ENSG00000132688
Uniprot IDs		Q00535	P48681 Q9H6U9
PDB IDs		1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8
Enriched GO Terms of Interacting Partners?		Nervous System Development Neurogenesis Regulation Of Cellular Component Organization Generation Of Neurons Regulation Of Protein Metabolic Process System Development Neuron Development Neuron Projection Development Multicellular Organismal Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Differentiation Regulation Of Cellular Protein Metabolic Process Anatomical Structure Development Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Cell Projection Organization Regulation Of Catalytic Activity Cell Differentiation Cell Morphogenesis Involved In Differentiation Axonogenesis Neuron Projection Morphogenesis Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Developmental Process Brain Development Positive Regulation Of Cellular Protein Metabolic Process Axon Development Head Development Cellular Localization Regulation Of Organelle Organization Regulation Of Phosphorylation Cell Projection Morphogenesis Regulation Of Signaling Cell Development Central Nervous System Development Cell Part Morphogenesis Organelle Organization Locomotion Axon Guidance Cell Morphogenesis Anatomical Structure Morphogenesis Movement Of Cell Or Subcellular Component Cell Cycle Organelle Localization Regulation Of Neuron Death Regulation Of Cellular Localization Signaling Positive Regulation Of Protein Modification Process Regulation Of Metabolic Process	Peptidyl-threonine Phosphorylation Serine Phosphorylation Of STAT3 Protein Serine Phosphorylation Of STAT Protein Peptidyl-serine Phosphorylation Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Negative Regulation Of Axon Extension Regulation Of Developmental Growth Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Protein Transport Layer Formation In Cerebral Cortex Axon Guidance Cerebral Cortex Radial Glia Guided Migration Regulation Of Dendritic Spine Development Regulation Of Intracellular Transport Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Neuron Apoptotic Process Cerebral Cortex Radially Oriented Cell Migration Negative Regulation Of Axonogenesis Glial Cell Migration Axonogenesis Regulation Of Cellular Protein Metabolic Process Regulation Of Axon Extension Positive Regulation Of Transferase Activity Regulation Of Dendrite Morphogenesis Hippocampus Development Axon Development Positive Regulation Of Neuron Death Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Regulation Of Growth Regulation Of Protein Transport Regulation Of Protein Metabolic Process Neuron Projection Morphogenesis Negative Regulation Of Developmental Growth Cerebral Cortex Cell Migration Regulation Of JAK-STAT Cascade Regulation Of Proteolysis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Limbic System Development Regulation Of Cell Cycle Arrest Regulation Of Neurogenesis Negative Regulation Of Cell Morphogenesis Involved In Differentiation Telencephalon Cell Migration Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation
Tagcloud ?		accelerates antisense axonal besides cerebellar collectively cones constituents cytoskeleton designated elongation epitope extension isoform laminin linker machinery macroneurons map1b oligonucleotide p35 p39 proline redistribution reduces selectively stimulates subcellular subcortical	autoinhibitory bipartite carries cytoplasm exclusively export exportin gfp hydrophobic import keywords leptomycin leucine mapkap mimicry mk2 nls overlapping redistribution rev sb203580 spacing supposed t317 t317a translocates translocation unexpectedly unlike
Tagcloud (Difference) ?		accelerates antisense axonal besides cerebellar collectively cones constituents cytoskeleton designated elongation epitope extension isoform laminin linker machinery macroneurons map1b oligonucleotide p35 p39 proline reduces selectively stimulates subcellular subcortical	autoinhibitory bipartite carries cytoplasm exclusively export exportin gfp hydrophobic import keywords leptomycin leucine mapkap mimicry mk2 nls overlapping rev sb203580 spacing supposed t317 t317a translocates translocation unexpectedly unlike
Tagcloud (Intersection) ?		redistribution