CDK5 and CDKN1B

Number of citations of the paper that reports this interaction (PubMedID 15890360)
0

Data Source:
HPRD (in vitro)

		CDK5	CDKN1B
Description		cyclin dependent kinase 5	cyclin dependent kinase inhibitor 1B
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Plasma Membrane Postsynaptic Density Membrane Protein Kinase 5 Complex Lamellipodium Cell Junction Filopodium Axon Dendrite Growth Cone Neuromuscular Junction Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Synapse Presynapse	Nucleus Nucleoplasm Cytoplasm Endosome Centrosome Cytosol Cilium Cul4A-RING E3 Ubiquitin Ligase Complex Ciliary Basal Body
	Molecular Function	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity ErbB-2 Class Receptor Binding Protein Binding ATP Binding Microtubule Binding Kinase Activity Transferase Activity Signaling Receptor Inhibitor Activity Acetylcholine Receptor Activator Activity Ionotropic Glutamate Receptor Binding ErbB-3 Class Receptor Binding Tau Protein Binding Tau-protein Kinase Activity Hsp90 Protein Binding Protein Serine Kinase Activity	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding Cyclin-dependent Protein Kinase Regulator Activity Cyclin Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Protein-folding Chaperone Binding Molecular Adaptor Activity Molecular Function Inhibitor Activity Ubiquitin Ligase Activator Activity
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Synaptic Transmission, Dopaminergic Intracellular Protein Transport Apoptotic Process Cell-matrix Adhesion Chemical Synaptic Transmission Nervous System Development Axonogenesis Synapse Assembly Skeletal Muscle Tissue Development Motor Neuron Axon Guidance Associative Learning Visual Learning Schwann Cell Development Synaptic Vesicle Exocytosis Regulation Of Macroautophagy Cell Migration Sensory Perception Of Pain Telencephalon Development Cerebellum Development Cerebellar Cortex Development Cerebellar Cortex Formation Hippocampus Development Layer Formation In Cerebral Cortex Central Nervous System Neuron Development Cerebral Cortex Development Corpus Callosum Development Actin Cytoskeleton Organization Neuron Differentiation Regulation Of Cell Migration Negative Regulation Of Axon Extension Forebrain Development Neuron Projection Development Negative Regulation Of Protein Ubiquitination Negative Regulation Of Synaptic Plasticity Receptor Catabolic Process Synaptic Transmission, Glutamatergic Protein Localization To Synapse Response To Cocaine Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Cycle Negative Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Protein Export From Nucleus Behavioral Response To Cocaine Regulation Of Synaptic Plasticity Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Rhythmic Process Axon Extension Oligodendrocyte Differentiation Dendrite Morphogenesis Cell Division Neuron Apoptotic Process Establishment Of Localization In Cell Regulation Of Cell Cycle Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Regulation Of Dendritic Spine Morphogenesis Calcium Ion Import Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Regulation Of Cell Cycle Phase Transition Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Synaptic Vesicle Recycling Cellular Response To Amyloid-beta	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Placenta Development Potassium Ion Transport Apoptotic Process Regulation Of Exit From Mitosis Notch Signaling Pathway Regulation Of Mitotic Cell Cycle Heart Development Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Programmed Cell Death Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Migration Positive Regulation Of Microtubule Polymerization Negative Regulation Of Kinase Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of DNA Replication Negative Regulation Of DNA-templated Transcription Negative Regulation Of Growth Negative Regulation Of Mitotic Cell Cycle Autophagic Cell Death Inner Ear Development Negative Regulation Of Epithelial Cell Proliferation Nuclear Export Regulation Of Cell Cycle Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Antibiotic Cellular Response To Lithium Ion Cellular Senescence Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Lens Fiber Cell Differentiation Regulation Of Cell Cycle G1/S Phase Transition Epithelial Cell Apoptotic Process Negative Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Tissue Regeneration Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		DARPP-32 events CRMPs in Sema3A signaling CRMPs in Sema3A signaling Regulation of TP53 Activity through Phosphorylation Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NGF-stimulated transcription Activated NTRK2 signals through CDK5 NPAS4 regulates expression of target genes Factors involved in megakaryocyte development and platelet production MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence RHO GTPases activate CIT Constitutive Signaling by AKT1 E17K in Cancer TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates Cell Cycle FLT3 Signaling FOXO-mediated transcription of cell cycle genes Estrogen-dependent nuclear events downstream of ESR-membrane signaling Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs		Indirubin-3'-monoxime Olomoucine Hymenialdisine SU9516 Alvocidib Alsterpaullone 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE Trilaciclib
Diseases			Prostate cancer
GWAS		Age at first sexual intercourse ( 34211149) Eyebrow thickness ( 26926045) Hematocrit ( 32888494) Hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494)	Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30487518) Mean arterial pressure ( 29403010 30487518) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Plateletcrit ( 32888494) Prostate cancer ( 29892016 31562322) Refractive error ( 32231278) Systemic lupus erythematosus ( 23273568 33272962) Systolic blood pressure ( 30487518) Type 2 diabetes ( 30297969)
Interacting Genes		78 interacting genes: AATK ABL1 ACTN1 ALAS1 AMPH APP BAG6 CABLES1 CABLES2 CCND2 CCND3 CCNG1 CDC25A CDC25B CDC25C CDC37 CDK16 CDK5R1 CDK5R2 CDK5RAP1 CDK5RAP2 CDKN1B CHN1 CSNK1D DAB1 DCX DNM1 ERBB3 EZR FSD1 FYN FZR1 GAK GRIN2A GSK3B H1-0 H1-1 H1-5 HTRA2 KIF26B LMTK2 MAP2K1 MAPK10 MAPT MAST1 MBP MEF2A MEOX2 MIR9-1HG NDEL1 NEDD4 NEDD4L NES PAK1 PCNA PIKFYVE PIP5K1C PPARG PPP1R1B PPP1R2 PSEN1 PTPN2 PURA RB1 RNF32 RPL34 SET SPDYA SRC STX1A STXBP1 SYN1 SYNJ1 TLN1 TP53 TRIM59 WASF1 YBX3	70 interacting genes: ABL1 AKT1 ARHGDIA ARIH1 CAMK1 CASP8 CCNA1 CCNA2 CCNB1 CCND1 CCND2 CCND3 CCNE2 CDC34 CDK2 CDK3 CDK4 CDK5 CKS1B COP1 COPS5 CUL4A DCLRE1C GRB2 H1-1 H1-5 IRF1 KAT2B KPNA1 KPNA3 KPNA4 KPNA5 KPNA6 LYN MAPK10 MCM7 MTUS2 MYC NUP50 PIN1 PSMB1 RCHY1 RNF123 RNF6 RPS6KA1 SGK1 SIRT6 SKP1 SKP2 SPDYA SRC STMN1 TRAF2 TSC2 UBAC1 UBB UBE2B UBE2D2 UBE2L3 UBE3A UCHL1 WWP1 XPO1 YES1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		1020	1027
HPRD ID		00449	02867
Ensembl ID		ENSG00000164885	ENSG00000111276
Uniprot IDs		A0A090N7W4 A0A0S2Z355 Q00535	P46527 Q6I9V6
PDB IDs		1H4L 1UNG 1UNH 1UNL 3O0G 4AU8 7VDP 7VDQ 7VDR 7VDS	1H27 1JSU 2AST 5UQ3 6ATH 6P8E 6P8F 6P8G 7B5L 7B5M 7B5R 7OR8 7ORG 7ORH 7ORS 7ORT 8BYA 8BYL 8BZO
Enriched GO Terms of Interacting Partners?		Protein Kinase Binding Cytosol Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Developmental Process Regulation Of Protein Modification Process Intracellular Signal Transduction Mitotic Cell Cycle Phase Transition Regulation Of Cellular Component Organization Regulation Of Neuron Apoptotic Process Cell Cycle Phase Transition Regulation Of Protein Serine/threonine Kinase Activity Organelle Organization Perinuclear Region Of Cytoplasm Regulation Of Protein Kinase Activity Cytoplasm Cyclin-dependent Protein Kinase Holoenzyme Complex Neuron Apoptotic Process Regulation Of Organelle Organization Regulation Of Kinase Activity Kinase Activity Cell Projection Organization G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Phosphorus Metabolic Process Protein Kinase Activity Regulation Of Phosphorylation Regulation Of Cell Projection Organization Regulation Of Neuron Projection Development Cellular Developmental Process Regulation Of Apoptotic Process Endocytosis Layer Formation In Cerebral Cortex Regulation Of Protein Phosphorylation Organelle Localization Positive Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Regulation Of Mitotic Cell Cycle Regulation Of Protein-containing Complex Assembly Positive Regulation Of Organelle Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Negative Regulation Of Programmed Cell Death	Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Protein Modification Process Nucleus Cell Cycle Phase Transition Nucleoplasm Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cytosol Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cytoplasm Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Metabolic Process Macromolecule Catabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Modification By Small Protein Conjugation Protein Ubiquitination Regulation Of Cell Cycle Proteolysis Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein Domain Specific Binding Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Intracellular Signal Transduction Catabolic Process Protein Polyubiquitination Protein Localization To Nucleus Transferase Activity NLS-dependent Protein Nuclear Import Complex Regulation Of Macromolecule Metabolic Process Protein Catabolic Process Regulation Of Metabolic Process Ubiquitin-protein Transferase Activity NLS-bearing Protein Import Into Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Proteasomal Protein Catabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Regulation Of DNA Metabolic Process Protein Import Into Nucleus Import Into Nucleus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Ubiquitin Protein Ligase Binding Protein Kinase Binding Phosphoserine Residue Binding
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