CDK5 and FYN

Number of citations of the paper that reports this interaction (PubMedID 12372285)
0

Data Source:
HPRD (in vivo)

		CDK5	FYN
Description		cyclin dependent kinase 5	FYN proto-oncogene, Src family tyrosine kinase
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Plasma Membrane Postsynaptic Density Membrane Protein Kinase 5 Complex Lamellipodium Cell Junction Filopodium Axon Dendrite Growth Cone Neuromuscular Junction Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Synapse Presynapse	Nucleus Cytoplasm Mitochondrion Endosome Cytosol Actin Filament Plasma Membrane Postsynaptic Density Membrane Dendrite Perikaryon Cell Body Membrane Raft Perinuclear Region Of Cytoplasm Cell Periphery Perinuclear Endoplasmic Reticulum Glial Cell Projection Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity ErbB-2 Class Receptor Binding Protein Binding ATP Binding Microtubule Binding Kinase Activity Transferase Activity Signaling Receptor Inhibitor Activity Acetylcholine Receptor Activator Activity Ionotropic Glutamate Receptor Binding ErbB-3 Class Receptor Binding Tau Protein Binding Tau-protein Kinase Activity Hsp90 Protein Binding Protein Serine Kinase Activity	Nucleotide Binding G Protein-coupled Receptor Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Tubulin Binding Phospholipase Activator Activity Kinase Activity Transferase Activity Enzyme Binding Type 5 Metabotropic Glutamate Receptor Binding T Cell Receptor Binding CD4 Receptor Binding CD8 Receptor Binding Identical Protein Binding Alpha-tubulin Binding Phospholipase Binding Phosphatidylinositol 3-kinase Binding Transmembrane Transporter Binding Protein-containing Complex Binding Metal Ion Binding Ephrin Receptor Binding Tau Protein Binding Tau-protein Kinase Activity Peptide Hormone Receptor Binding Growth Factor Receptor Binding Scaffold Protein Binding Disordered Domain Specific Binding
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Synaptic Transmission, Dopaminergic Intracellular Protein Transport Apoptotic Process Cell-matrix Adhesion Chemical Synaptic Transmission Nervous System Development Axonogenesis Synapse Assembly Skeletal Muscle Tissue Development Motor Neuron Axon Guidance Associative Learning Visual Learning Schwann Cell Development Synaptic Vesicle Exocytosis Regulation Of Macroautophagy Cell Migration Sensory Perception Of Pain Telencephalon Development Cerebellum Development Cerebellar Cortex Development Cerebellar Cortex Formation Hippocampus Development Layer Formation In Cerebral Cortex Central Nervous System Neuron Development Cerebral Cortex Development Corpus Callosum Development Actin Cytoskeleton Organization Neuron Differentiation Regulation Of Cell Migration Negative Regulation Of Axon Extension Forebrain Development Neuron Projection Development Negative Regulation Of Protein Ubiquitination Negative Regulation Of Synaptic Plasticity Receptor Catabolic Process Synaptic Transmission, Glutamatergic Protein Localization To Synapse Response To Cocaine Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Cycle Negative Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Protein Export From Nucleus Behavioral Response To Cocaine Regulation Of Synaptic Plasticity Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Rhythmic Process Axon Extension Oligodendrocyte Differentiation Dendrite Morphogenesis Cell Division Neuron Apoptotic Process Establishment Of Localization In Cell Regulation Of Cell Cycle Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Regulation Of Dendritic Spine Morphogenesis Calcium Ion Import Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Regulation Of Cell Cycle Phase Transition Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Synaptic Vesicle Recycling Cellular Response To Amyloid-beta	Response To Singlet Oxygen Neuron Migration Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response Immune System Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Heart Process Calcium Ion Transport Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Axon Guidance Learning Feeding Behavior Regulation Of Cell Shape Response To Xenobiotic Stimulus Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Neuron Projection Development Negative Regulation Of Angiogenesis Protein Ubiquitination Peptidyl-tyrosine Phosphorylation Layer Formation In Cerebral Cortex Natural Killer Cell Activation Cell Differentiation Protein Catabolic Process Forebrain Development Neuron Projection Development T Cell Costimulation Negative Regulation Of Protein Ubiquitination Intracellular Signal Transduction Cellular Response To Platelet-derived Growth Factor Stimulus Reelin-mediated Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Protein Catabolic Process Response To Cocaine Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Dendrite Morphogenesis Activated T Cell Proliferation Modulation Of Chemical Synaptic Transmission T Cell Receptor Signaling Pathway Leukocyte Migration Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Hydrogen Peroxide Cellular Response To Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Protein Targeting To Membrane Dendritic Spine Maintenance Positive Regulation Of Protein Localization To Nucleus Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Dendritic Spine Maintenance Response To Amyloid-beta Cellular Response To Amyloid-beta Cellular Response To L-glutamate Cellular Response To Glycine Positive Regulation Of Protein Localization To Membrane Regulation Of Calcium Ion Import Across Plasma Membrane Regulation Of Neuron Migration Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		DARPP-32 events CRMPs in Sema3A signaling CRMPs in Sema3A signaling Regulation of TP53 Activity through Phosphorylation Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NGF-stimulated transcription Activated NTRK2 signals through CDK5 NPAS4 regulates expression of target genes Factors involved in megakaryocyte development and platelet production MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	GPVI-mediated activation cascade Signaling by ERBB2 PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Nef and signal transduction Cell surface interactions at the vascular wall FCGR activation PECAM1 interactions Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling DAP12 signaling EPH-Ephrin signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway Co-inhibition by CTLA4 EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling VEGFA-VEGFR2 Pathway Dectin-2 family CD209 (DC-SIGN) signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Platelet Adhesion to exposed collagen Reelin signalling pathway Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by CSF1 (M-CSF) in myeloid cells FLT3 signaling through SRC family kinases Antigen activates B Cell Receptor (BCR) leading to generation of second messengers High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Indirubin-3'-monoxime Olomoucine Hymenialdisine SU9516 Alvocidib Alsterpaullone 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE Trilaciclib	Dasatinib Triglyme Fostamatinib Zotiraciclib
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Eyebrow thickness ( 26926045) Hematocrit ( 32888494) Hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anger ( 24489884) Autoimmune thyroid disease ( 32581359) Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Inflammatory bowel disease ( 28067908 23128233) Intraocular pressure ( 29617998) Macular thickness ( 30535121) NASH resolution in nonalcoholic steatohepatitis ( 31832568) Parkinson's disease ( 32201043 32310270) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 28991256 30285260) Systolic blood pressure ( 30578418) Ulcerative colitis ( 28067908)
Interacting Genes		78 interacting genes: AATK ABL1 ACTN1 ALAS1 AMPH APP BAG6 CABLES1 CABLES2 CCND2 CCND3 CCNG1 CDC25A CDC25B CDC25C CDC37 CDK16 CDK5R1 CDK5R2 CDK5RAP1 CDK5RAP2 CDKN1B CHN1 CSNK1D DAB1 DCX DNM1 ERBB3 EZR FSD1 FYN FZR1 GAK GRIN2A GSK3B H1-0 H1-1 H1-5 HTRA2 KIF26B LMTK2 MAP2K1 MAPK10 MAPT MAST1 MBP MEF2A MEOX2 MIR9-1HG NDEL1 NEDD4 NEDD4L NES PAK1 PCNA PIKFYVE PIP5K1C PPARG PPP1R1B PPP1R2 PSEN1 PTPN2 PURA RB1 RNF32 RPL34 SET SPDYA SRC STX1A STXBP1 SYN1 SYNJ1 TLN1 TP53 TRIM59 WASF1 YBX3	199 interacting genes: ACP1 ADAM15 ADD2 ARHGAP32 ARHGAP33 ATXN1 BAG4 BCAR1 BCL3 BTK C7orf25 C8orf33 CASP3 CASP8 CAV1 CBL CBLB CBLC CD19 CD2 CD226 CD247 CD2AP CD36 CD44 CD48 CD5 CD55 CD79A CD79B CDH1 CDK1 CDK5 CLTC CMA1 CNN1 CNN3 CNTN1 CNTNAP1 CRK CSF1R CSF2RB CSK CTLA4 CTNNB1 CTNND2 DAG1 DLG4 DLGAP4 DOK1 DOK3 DOK4 DTX3 EFS ENO1 EPHA3 EPHA4 EPHA8 EPHB3 EVL FAM90A1 FAS FASLG FCER2 FCGR2A FLOT1 FLOT2 FLT1 FNBP4 FYB1 GAB3 GP6 GRAP GRB10 GRB2 GRIN1 GRIN2A GRIN2B GRSF1 HNRNPK HRAS HSP90AA1 HTR6 IGHA1 IL1B IL2RB IL7R IRS1 ITCH ITGB4 ITK ITPR1 JAK2 JUP KDM1A KDR KHDRBS1 KIT LAT LCK LCP2 MAG MAP2 MAPT MCAM MED28 MEOX2 MS4A1 NCAM1 NEDD4 NEDD9 NMT1 NOS1AP NPHS1 NR3C1 NTRK2 PAG1 PAK2 PDE4D PDGFRB PECAM1 PIK3R1 PIK3R2 PIK3R3 PLAUR PLCG1 PLCG2 PLD2 PRKCD PRKCE PRKCH PRKCQ PRKCZ PRMT6 PRMT8 PRRG4 PTK2 PTK2B PTPN11 PTPN5 PTPRA PTPRC PTPRE PTPRF PTPRZ1 PXN RACK1 RAF1 RPL10 RPS6KA3 RPS6KB2 SDC3 SH2B2 SH2D1A SH3BP2 SHC1 SIT1 SKAP1 SKAP2 SLAMF1 SNCA SOCS1 SOS1 SPHK1 SPHK2 SPN STAT1 STAT3 SUV39H1 SYK TAMALIN TCAP THY1 TNF TNK2 TNNT1 TOM1L1 TRAF6 TRAT1 TRIM55 TRIM63 TRPC6 TRPV4 TUBA1B TUBA3C TUBA4A TXK TYK2 TYRO3 UHRF2 UNC119 VAV1 VAV2 WAS WASF1 WASF2 WBP11 YTHDC1 ZAP70
Entrez ID		1020	2534
HPRD ID		00449	00655
Ensembl ID		ENSG00000164885	ENSG00000010810
Uniprot IDs		A0A090N7W4 A0A0S2Z355 Q00535	P06241
PDB IDs		1H4L 1UNG 1UNH 1UNL 3O0G 4AU8 7VDP 7VDQ 7VDR 7VDS	1A0N 1AOT 1AOU 1AVZ 1AZG 1EFN 1FYN 1G83 1M27 1NYF 1NYG 1SHF 1ZBJ 2DQ7 2MQI 2MRJ 2MRK 3H0F 3H0H 3H0I 3UA6 3UA7 4D8D 4EIK 4U17 4U1P 4ZNX 5ZAU 6EDF 6IPY 6IPZ 7A2J 7A2K 7A2L 7A2M 7A2N 7A2O 7A2P 7A2Q 7A2R 7A2S 7A2T 7A2U 7A2V 7A2W 7A2X 7A2Y 7A2Z 7UD6 8KDX
Enriched GO Terms of Interacting Partners?		Protein Kinase Binding Cytosol Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Developmental Process Regulation Of Protein Modification Process Intracellular Signal Transduction Mitotic Cell Cycle Phase Transition Regulation Of Cellular Component Organization Regulation Of Neuron Apoptotic Process Cell Cycle Phase Transition Regulation Of Protein Serine/threonine Kinase Activity Organelle Organization Perinuclear Region Of Cytoplasm Regulation Of Protein Kinase Activity Cytoplasm Cyclin-dependent Protein Kinase Holoenzyme Complex Neuron Apoptotic Process Regulation Of Organelle Organization Regulation Of Kinase Activity Kinase Activity Cell Projection Organization G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Phosphorus Metabolic Process Protein Kinase Activity Regulation Of Phosphorylation Regulation Of Cell Projection Organization Regulation Of Neuron Projection Development Cellular Developmental Process Regulation Of Apoptotic Process Endocytosis Layer Formation In Cerebral Cortex Regulation Of Protein Phosphorylation Organelle Localization Positive Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Regulation Of Mitotic Cell Cycle Regulation Of Protein-containing Complex Assembly Positive Regulation Of Organelle Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Negative Regulation Of Programmed Cell Death	Cell Surface Receptor Signaling Pathway Signal Transduction Plasma Membrane Immune System Process Regulation Of Immune System Process Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Immune Response Immune Response-activating Signaling Pathway Activation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Cell Adhesion Leukocyte Activation Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Regulation Of Cellular Component Organization Phosphotyrosine Residue Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Lymphocyte Activation Positive Regulation Of Cell Adhesion Membrane Raft Regulation Of Cell Activation T Cell Receptor Signaling Pathway Cell Migration Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Protein Tyrosine Kinase Activity Immune Response Regulation Of Cell-cell Adhesion Regulation Of Programmed Cell Death Intracellular Signaling Cassette Fc Receptor Signaling Pathway Regulation Of Apoptotic Process SH2 Domain Binding Adaptive Immune Response Cell Adhesion Protein Kinase Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?