ECSIT and NDUFA13

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		ECSIT	NDUFA13
Description		ECSIT signaling integrator	NADH:ubiquinone oxidoreductase subunit A13
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex I Respiratory Chain Complex
	Molecular Function	Protein Binding Molecular Adaptor Activity	Protein Binding ATP Binding Endopeptidase Activator Activity
	Biological Process	Immune System Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Mitochondrial Respiratory Chain Complex I Assembly Toll-like Receptor 4 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability	Apoptotic Process Aerobic Respiration Mitochondrial Respiratory Chain Complex I Assembly Cellular Response To Interferon-beta Proton Motive Force-driven Mitochondrial ATP Synthesis Protein Insertion Into Mitochondrial Inner Membrane Positive Regulation Of Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Cellular Response To Retinoic Acid Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane	Respiratory electron transport Complex I biogenesis Mitochondrial protein degradation
Drugs			NADH
Diseases
GWAS		Presence of antiphospholipid antibodies ( 27098658)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Platelet count ( 27863252) Refractive error ( 32231278) Schizophrenia ( 23974872 25056061 29483656)
Interacting Genes		53 interacting genes: A2M AIRIM AP1M2 APOE APP BFSP2 BLMH CDC37 CEP55 CTNNA3 CYP2C18 CYP2C8 CYP2C9 DNAJB1 DTX2 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH GEM IFIT3 IFIT5 IMMT LONP1 LOXL4 MAGEB2 MAST1 MKRN3 NFKB1 NXF1 OGT PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TARS3 TRAF6 TRIM59 TSSK3	7 interacting genes: EXOSC6 HSPB2 KRAS LIG4 STAT3 UBE3A XRN1
Entrez ID		51295	51079
HPRD ID		12225	09452
Ensembl ID		ENSG00000130159	ENSG00000186010
Uniprot IDs		Q9BQ95	Q9P0J0
PDB IDs			5XTB 5XTC 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Catabolic Process Arachidonate Epoxygenase Activity Lipoprotein Particle Regulation Of MiRNA Metabolic Process Epoxygenase P450 Pathway NF-kappaB P50/p65 Complex Positive Regulation Of Protein Metabolic Process I-SMAD Binding Cellular Response To Interleukin-6 Cytoplasm Regulation Of Amyloid Fibril Formation Response To Interleukin-6 Positive Regulation Of Proteolysis Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Astrocyte Activation Involved In Immune Response Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Xenobiotic Catabolic Process Caffeine Oxidase Activity Magnesium Ion Binding Response To Virus Positive Regulation Of MiRNA Metabolic Process Intermediate-density Lipoprotein Particle Growth Factor Receptor Binding Regulation Of MiRNA Transcription Antiviral Innate Immune Response Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Metabolic Process SMAD Protein Complex Neuronal Cell Body Protein Ubiquitination Oxidative Demethylation Retinoic Acid 4-hydroxylase Activity Heteromeric SMAD Protein Complex Cellular Response To Nicotine Protein Binding Innate Immune Response Cytosol Arachidonate Metabolic Process Omega-hydroxylase P450 Pathway Defense Response To Virus Defense Response To Tumor Cell Demethylation Protein Modification By Small Protein Conjugation Positive Regulation Of Catabolic Process Negative Regulation Of Long-term Synaptic Potentiation Cellular Response To Amyloid-beta Glutamatergic Synapse	Nuclear MRNA Surveillance RRNA Catabolic Process Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Somatic Diversification Of Immunoglobulins Involved In Immune Response Somatic Recombination Of Immunoglobulin Gene Segments Somatic Cell DNA Recombination Somatic Diversification Of Immunoglobulins RNA Surveillance Nuclear RNA Surveillance Response To Lipid B Cell Activation Involved In Immune Response Somatic Stem Cell Population Maintenance Establishment Of Integrated Proviral Latency Sperm Entry Positive Regulation Of Golgi Lumen Acidification Cellular Response To Puromycin Cellular Response To Cycloheximide Neuron Apoptotic Process GMP Binding Forebrain Astrocyte Development Modulation Of Chemical Synaptic Transmission DNA Ligase (ATP) Activity Stem Cell Population Maintenance DNA Ligase IV Complex Establishment Of Viral Latency Lymphocyte Activation Involved In Immune Response DNA Ligase Activity Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Golgi Lumen Acidification Nuclear-transcribed MRNA Catabolic Process Maintenance Of Cell Number Somatic Muscle Development Cytosol Response To Isolation Stress Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination DN2 Thymocyte Differentiation RNA Sequestering Activity 5'-3' RNA Exonuclease Activity MRNA Catabolic Process Positive Regulation Of Developmental Process Response To Hormone Leukocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response Postsynapse To Nucleus Signaling Pathway MRNA Metabolic Process
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