ECSIT and CNN1

		ECSIT	CNN1
Description		ECSIT signaling integrator	calponin 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol	Cytoskeleton Focal Adhesion Actin Cytoskeleton
	Molecular Function	Protein Binding Molecular Adaptor Activity	Actin Binding Protein Binding Calmodulin Binding Actin Filament Binding
	Biological Process	Immune System Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Mitochondrial Respiratory Chain Complex I Assembly Toll-like Receptor 4 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability	Regulation Of Smooth Muscle Contraction Actin Filament Organization Actomyosin Structure Organization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane	Developmental Lineage of Mammary Gland Myoepithelial Cells
Drugs
Diseases
GWAS		Presence of antiphospholipid antibodies ( 27098658)	Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		53 interacting genes: A2M AIRIM AP1M2 APOE APP BFSP2 BLMH CDC37 CEP55 CTNNA3 CYP2C18 CYP2C8 CYP2C9 DNAJB1 DTX2 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH GEM IFIT3 IFIT5 IMMT LONP1 LOXL4 MAGEB2 MAST1 MKRN3 NFKB1 NXF1 OGT PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TARS3 TRAF6 TRIM59 TSSK3	15 interacting genes: ACTA1 ADRB2 CALM1 CCHCR1 COG6 DNMBP FYN MYO1A NCAPD2 PLRG1 PRKCE SYCE1 TFPT TPM3 TUBB
Entrez ID		51295	1264
HPRD ID		12225	02884
Ensembl ID		ENSG00000130159	ENSG00000130176
Uniprot IDs		Q9BQ95	B7Z7E1 P51911 Q53FP8 V9HWA5
PDB IDs			1WYP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Catabolic Process Arachidonate Epoxygenase Activity Lipoprotein Particle Regulation Of MiRNA Metabolic Process Epoxygenase P450 Pathway NF-kappaB P50/p65 Complex Positive Regulation Of Protein Metabolic Process I-SMAD Binding Cellular Response To Interleukin-6 Cytoplasm Regulation Of Amyloid Fibril Formation Response To Interleukin-6 Positive Regulation Of Proteolysis Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Astrocyte Activation Involved In Immune Response Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Xenobiotic Catabolic Process Caffeine Oxidase Activity Magnesium Ion Binding Response To Virus Positive Regulation Of MiRNA Metabolic Process Intermediate-density Lipoprotein Particle Growth Factor Receptor Binding Regulation Of MiRNA Transcription Antiviral Innate Immune Response Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Metabolic Process SMAD Protein Complex Neuronal Cell Body Protein Ubiquitination Oxidative Demethylation Retinoic Acid 4-hydroxylase Activity Heteromeric SMAD Protein Complex Cellular Response To Nicotine Protein Binding Innate Immune Response Cytosol Arachidonate Metabolic Process Omega-hydroxylase P450 Pathway Defense Response To Virus Defense Response To Tumor Cell Demethylation Protein Modification By Small Protein Conjugation Positive Regulation Of Catabolic Process Negative Regulation Of Long-term Synaptic Potentiation Cellular Response To Amyloid-beta Glutamatergic Synapse	Actin Filament Chromosome Organization Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Cell Body Mitotic Chromosome Condensation Cellular Response To Prostaglandin E Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Cellular Response To Prostaglandin Stimulus Regulation Of Metal Ion Transport Response To Prostaglandin E Mitotic Cell Cycle Protein-containing Complex Binding Regulation Of Calcium Ion Transmembrane Transport Cell Cycle Phase Transition Fc-gamma Receptor Signaling Pathway Condensed Chromosome Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Regulation Of Monoatomic Ion Transport Innate Immune Response-activating Signaling Pathway Cellular Response To Glycine Response To Singlet Oxygen Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Chromosome Condensation Cell Division Muscle Contraction Glutamate Receptor Signaling Pathway Cellular Response To Amyloid-beta Activation Of Innate Immune Response Cytoplasm Sarcomere Cellular Response To Oxygen-containing Compound Positive Regulation Of Organelle Organization Modulation Of Chemical Synaptic Transmission Cell Cycle G2/M Phase Transition Regulation Of Calcium Ion Transport Fc Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Chromosome Organization Involved In Meiotic Cell Cycle Response To Amyloid-beta Beta2-adrenergic Receptor Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Glycine Ethanol Binding Regulation Of Chromosome Organization Muscle System Process
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