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ECSIT and TRIM59
Number of citations of the paper that reports this interaction (PubMedID
22588174
)
0
Data Source:
BioGRID
(two hybrid)
ECSIT
TRIM59
Description
ECSIT signaling integrator
tripartite motif containing 59
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Inner Membrane
Cytosol
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Membrane
Intraciliary Transport Particle B
Molecular Function
Protein Binding
Molecular Adaptor Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Immune System Process
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Mitochondrial Respiratory Chain Complex I Assembly
Toll-like Receptor 4 Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Innate Immune Response
Regulation Of Oxidoreductase Activity
Regulation Of Protein Complex Stability
Protein Ubiquitination
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Host-mediated Suppression Of Symbiont Invasion
Pathways
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Complex I biogenesis
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS
Presence of antiphospholipid antibodies (
27098658
)
Alanine aminotransferase levels (
33547301
)
Alcohol use disorder (total score) (
30336701
)
Aspartate aminotransferase levels (
33547301
)
Bipolar disorder (
31043756
)
Eosinophil percentage of white cells (
32888494
)
Intrinsic epigenetic age acceleration (
29374233
)
Malaria (
31844061
)
Pulse pressure (
30578418
)
Systolic blood pressure (
30578418
)
Interacting Genes
53 interacting genes:
A2M
AIRIM
AP1M2
APOE
APP
BFSP2
BLMH
CDC37
CEP55
CTNNA3
CYP2C18
CYP2C8
CYP2C9
DNAJB1
DTX2
ELAVL3
EXOC6
EXOSC1
FARSA
FBXL12
FBXW4
GCDH
GEM
IFIT3
IFIT5
IMMT
LONP1
LOXL4
MAGEB2
MAST1
MKRN3
NFKB1
NXF1
OGT
PAXIP1
PI4K2A
PRDX2
PSEN1
RAB3A
RAD23A
RELA
RHEB
RNF32
SETDB1
SMAD1
SMAD4
SMURF1
STAMBPL1
STRN4
TARS3
TRAF6
TRIM59
TSSK3
29 interacting genes:
ANKRD33
BLZF1
CCDC33
CDK5
CLDN4
ECSIT
EIF2B1
ESR1
ESR2
KEAP1
KRTAP13-3
MACROH2A1
MEI4
MRPL12
NECAB2
NRM
PIN1
PKNOX1
PLLP
RASSF3
RHOU
SEC22A
SNAP47
SYVN1
UBE2J2
UBE2W
VTI1B
ZDHHC21
ZDHHC22
Entrez ID
51295
286827
HPRD ID
12225
15568
Ensembl ID
ENSG00000130159
ENSG00000213186
Uniprot IDs
Q9BQ95
Q8IWR1
PDB IDs
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Amyloid Fibril Formation
Regulation Of Protein Catabolic Process
Arachidonate Epoxygenase Activity
Lipoprotein Particle
Regulation Of MiRNA Metabolic Process
Epoxygenase P450 Pathway
NF-kappaB P50/p65 Complex
Positive Regulation Of Protein Metabolic Process
I-SMAD Binding
Cellular Response To Interleukin-6
Cytoplasm
Regulation Of Amyloid Fibril Formation
Response To Interleukin-6
Positive Regulation Of Proteolysis
Protein Metabolic Process
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Astrocyte Activation Involved In Immune Response
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen
Xenobiotic Catabolic Process
Caffeine Oxidase Activity
Magnesium Ion Binding
Response To Virus
Positive Regulation Of MiRNA Metabolic Process
Intermediate-density Lipoprotein Particle
Growth Factor Receptor Binding
Regulation Of MiRNA Transcription
Antiviral Innate Immune Response
Non-canonical NF-kappaB Signal Transduction
Regulation Of Protein Metabolic Process
SMAD Protein Complex
Neuronal Cell Body
Protein Ubiquitination
Oxidative Demethylation
Retinoic Acid 4-hydroxylase Activity
Heteromeric SMAD Protein Complex
Cellular Response To Nicotine
Protein Binding
Innate Immune Response
Cytosol
Arachidonate Metabolic Process
Omega-hydroxylase P450 Pathway
Defense Response To Virus
Defense Response To Tumor Cell
Demethylation
Protein Modification By Small Protein Conjugation
Positive Regulation Of Catabolic Process
Negative Regulation Of Long-term Synaptic Potentiation
Cellular Response To Amyloid-beta
Glutamatergic Synapse
Nuclear Estrogen Receptor Activity
SNAP Receptor Activity
Negative Regulation Of Response To Oxidative Stress
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Tagcloud (Difference)
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Tagcloud (Intersection)
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