ECSIT and TRIM59

Number of citations of the paper that reports this interaction (PMID 22588174)
1

Data Source:
BioGRID (two hybrid)

		ECSIT	TRIM59
Gene Name		ECSIT signalling integrator	tripartite motif containing 59
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Mitochondrion	Intracellular Integral Component Of Membrane
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Oxidoreductase Activity, Acting On NAD(P)H	Zinc Ion Binding
	Biological Process	Mesoderm Formation BMP Signaling Pathway Innate Immune Response Regulation Of Oxidoreductase Activity Oxidation-reduction Process	Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		42 interactors: A2M AP1M2 APOE APP BLMH CDC37 CEP55 CYP2C18 CYP2C8 CYP2C9 DNAJB1 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH IFIT3 IFIT5 IMMT LONP1 LOXL4 MAST1 NFKB1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TRAF6 TRIM59	6 interactors: ECSIT ESR1 ESR2 NRM VTI1B ZDHHC22
Entrez ID		51295	286827
HPRD ID		12225	15568
Ensembl ID		ENSG00000130159	ENSG00000213186
Uniprot IDs		K7EMM0 Q9BQ95	Q8IWR1
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Proteolysis Regulation Of Interleukin-12 Biosynthetic Process Cellular Response To Interleukin-1 Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Epoxygenase P450 Pathway Membrane Protein Intracellular Domain Proteolysis Catabolic Process Response To Oxidative Stress Exogenous Drug Catabolic Process Drug Catabolic Process Response To Abiotic Stimulus Response To Interleukin-1 Protein Metabolic Process Response To Stress Exocytosis Negative Regulation Of Cell Death Proteolysis Response To Stimulus T Cell Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of MiRNA Metabolic Process Drug Metabolic Process Cellular Response To Growth Factor Stimulus Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway NIK/NF-kappaB Signaling Response To Growth Factor Regulation Of Innate Immune Response Antigen Receptor-mediated Signaling Pathway Cellular Response To Nicotine Positive Regulation Of Interleukin-12 Biosynthetic Process Omega-hydroxylase P450 Pathway Cellular Response To Stimulus Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Apoptotic Process Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Programmed Cell Death Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of MiRNA Metabolic Process Negative Regulation Of Cholesterol Transport Regulation Of Interleukin-12 Production TRIF-dependent Toll-like Receptor Signaling Pathway Secretion By Cell Response To Drug SMAD Protein Complex Assembly Arachidonic Acid Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway	Vagina Development Uterus Development Intracellular Estrogen Receptor Signaling Pathway Female Genitalia Development Prostate Gland Epithelium Morphogenesis Prostate Gland Morphogenesis Genitalia Development Ovarian Follicle Development Prostate Gland Development Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Oxidoreductase Activity Ovulation Cycle Process Steroid Hormone Mediated Signaling Pathway Female Gonad Development Ovulation Cycle Development Of Primary Female Sexual Characteristics Tissue Morphogenesis Hormone-mediated Signaling Pathway Gland Morphogenesis Prostate Epithelial Cord Elongation Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Intracellular Receptor Signaling Pathway Epithelial Cell Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Epithelial Cell Maturation Involved In Prostate Gland Development Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Hormone-mediated Apoptotic Signaling Pathway DNA-templated Transcription, Initiation Gonad Development Branch Elongation Involved In Mammary Gland Duct Branching Antral Ovarian Follicle Growth Development Of Primary Sexual Characteristics Golgi To Vacuole Transport Regulation Of Branching Involved In Prostate Gland Morphogenesis Vesicle Fusion With Golgi Apparatus Mammary Gland Branching Involved In Pregnancy Sex Differentiation Rhythmic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Urogenital System Development Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Epithelial Cell Differentiation Involved In Prostate Gland Development Extracellular Negative Regulation Of Signal Transduction Positive Regulation Of Nitric-oxide Synthase Activity Cellular Response To Estradiol Stimulus
Tagcloud ?		1beta abolished adapter attributed augments consequence cytotrap evidenced evolutionarily gst hbx hbxdelta51 helenalin hepatitis ikappabalpha ikk interacted interacting kappab knockdown mechanistically nf p50 p65 pull tlr toll transactivates transfection	affiliated ags arrays bgc823 carcinogenesis clone gastric ges immunoblotting interacted knocked ligase messenger mkn45 n87 nanchang nontumor nude oncomine opposite physically renji sets sgc7901 snu1 snu5 tripartite ubiquitination xenograft
Tagcloud (Difference) ?		1beta abolished adapter attributed augments consequence cytotrap evidenced evolutionarily gst hbx hbxdelta51 helenalin hepatitis ikappabalpha ikk interacting kappab knockdown mechanistically nf p50 p65 pull tlr toll transactivates transfection	affiliated ags arrays bgc823 carcinogenesis clone gastric ges immunoblotting knocked ligase messenger mkn45 n87 nanchang nontumor nude oncomine opposite physically renji sets sgc7901 snu1 snu5 tripartite ubiquitination xenograft
Tagcloud (Intersection) ?		interacted