ECSIT and PI4K2A

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid)

		ECSIT	PI4K2A
Description		ECSIT signaling integrator	phosphatidylinositol 4-kinase type 2 alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol	Golgi Membrane Mitochondrion Lysosomal Membrane Endosome Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Endosome Membrane Membrane Dendrite BLOC-1 Complex Cytoplasmic Vesicle Early Endosome Membrane Growing Cell Tip Presynaptic Membrane Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Membrane Raft Synapse Presynaptic Active Zone Glutamatergic Synapse
	Molecular Function	Protein Binding Molecular Adaptor Activity	Nucleotide Binding Magnesium Ion Binding 1-phosphatidylinositol 4-kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity AP-3 Adaptor Complex Binding
	Biological Process	Immune System Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Mitochondrial Respiratory Chain Complex I Assembly Toll-like Receptor 4 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Golgi Organization Endosome Organization Phosphatidylinositol Phosphate Biosynthetic Process
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane
Drugs
Diseases
GWAS		Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		53 interacting genes: A2M AIRIM AP1M2 APOE APP BFSP2 BLMH CDC37 CEP55 CTNNA3 CYP2C18 CYP2C8 CYP2C9 DNAJB1 DTX2 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH GEM IFIT3 IFIT5 IMMT LONP1 LOXL4 MAGEB2 MAST1 MKRN3 NFKB1 NXF1 OGT PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TARS3 TRAF6 TRIM59 TSSK3	7 interacting genes: APP CD63 ECSIT HRAS NOS3 OGT RAD23A
Entrez ID		51295	55361
HPRD ID		12225	11431
Ensembl ID		ENSG00000130159	ENSG00000155252
Uniprot IDs		Q9BQ95	Q9BTU6
PDB IDs			4HND 4HNE 4PLA 4YC4 5EUT 5I0N
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Catabolic Process Arachidonate Epoxygenase Activity Lipoprotein Particle Regulation Of MiRNA Metabolic Process Epoxygenase P450 Pathway NF-kappaB P50/p65 Complex Positive Regulation Of Protein Metabolic Process I-SMAD Binding Cellular Response To Interleukin-6 Cytoplasm Regulation Of Amyloid Fibril Formation Response To Interleukin-6 Positive Regulation Of Proteolysis Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Astrocyte Activation Involved In Immune Response Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Xenobiotic Catabolic Process Caffeine Oxidase Activity Magnesium Ion Binding Response To Virus Positive Regulation Of MiRNA Metabolic Process Intermediate-density Lipoprotein Particle Growth Factor Receptor Binding Regulation Of MiRNA Transcription Antiviral Innate Immune Response Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Metabolic Process SMAD Protein Complex Neuronal Cell Body Protein Ubiquitination Oxidative Demethylation Retinoic Acid 4-hydroxylase Activity Heteromeric SMAD Protein Complex Cellular Response To Nicotine Protein Binding Innate Immune Response Cytosol Arachidonate Metabolic Process Omega-hydroxylase P450 Pathway Defense Response To Virus Defense Response To Tumor Cell Demethylation Protein Modification By Small Protein Conjugation Positive Regulation Of Catabolic Process Negative Regulation Of Long-term Synaptic Potentiation Cellular Response To Amyloid-beta Glutamatergic Synapse	Positive Regulation Of Proteolysis Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cell Migration Regulation Of Locomotion Regulation Of Cell Motility Endosome Lumen Positive Regulation Of Receptor Internalization Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Biological Quality Protein-containing Complex Positive Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Glycolytic Process Intracellular Signaling Cassette Response To Stress Positive Regulation Of Signaling Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Neuronal Synaptic Plasticity Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Amylin Binding Regulation Of Proteolysis Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Type II Interferon Production Regulation Of Protein Catabolic Process Regulation Of Metal Ion Transport Regulation Of Receptor Internalization Glial Cell Development Pigment Granule Maturation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Monoatomic Ion Transport Regulation Of Purine Nucleotide Metabolic Process Regulation Of Potassium Ion Transport Regulation Of MiRNA Metabolic Process Negative Regulation Of Multicellular Organismal Process Acetylcholine Receptor Activator Activity Positive Regulation Of Gene Expression Positive Regulation Of JNK Cascade Lipoprotein Particle Positive Regulation Of Protein Import GTPase Complex Smooth Muscle Hyperplasia Negative Regulation Of Muscle Hyperplasia
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?