Wiki-Pi
About
Search
People
Updates
Search
ECSIT and CYP2C18
Number of citations of the paper that reports this interaction (PubMedID
21163940
)
58
Data Source:
BioGRID
(two hybrid)
ECSIT
CYP2C18
Description
ECSIT signaling integrator
cytochrome P450 family 2 subfamily C member 18
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Inner Membrane
Cytosol
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Plasma Membrane
Membrane
Intracellular Membrane-bounded Organelle
Molecular Function
Protein Binding
Molecular Adaptor Activity
Monooxygenase Activity
Iron Ion Binding
Arachidonate Epoxygenase Activity
Retinoic Acid 4-hydroxylase Activity
Oxidoreductase Activity
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen
Oxygen Binding
Heme Binding
Metal Ion Binding
Linoleic Acid Epoxygenase Activity
Biological Process
Immune System Process
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Mitochondrial Respiratory Chain Complex I Assembly
Toll-like Receptor 4 Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Innate Immune Response
Regulation Of Oxidoreductase Activity
Regulation Of Protein Complex Stability
Lipid Metabolic Process
Terpenoid Metabolic Process
Xenobiotic Metabolic Process
Arachidonate Metabolic Process
Epoxygenase P450 Pathway
Monocarboxylic Acid Metabolic Process
Xenobiotic Catabolic Process
Retinol Metabolic Process
Retinoic Acid Metabolic Process
Linoleic Acid Metabolic Process
Pathways
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Complex I biogenesis
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 cascade initiated on plasma membrane
Xenobiotics
Drugs
N,4-Dimethyl-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
Diseases
GWAS
Presence of antiphospholipid antibodies (
27098658
)
Acenocoumarol maintenance dosage (
19578179
)
Clopidogrel active metabolite levels (
28207573
)
Common carotid intima-media thickness in HIV negative individuals (
29206233
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia (
30922102
)
Red cell distribution width (
32888494
)
Response to clopidogrel therapy (
19706858
28207573
)
Serum alkaline phosphatase levels (
33547301
)
Serum metabolite levels (
23093944
)
Thiopurine-induced alopecia in inflammatory bowel disease (
29923122
)
Warfarin maintenance dose (
23755828
)
Warfarin maintenance dose (adjusted for clinical factors) (
28686080
)
Interacting Genes
53 interacting genes:
A2M
AIRIM
AP1M2
APOE
APP
BFSP2
BLMH
CDC37
CEP55
CTNNA3
CYP2C18
CYP2C8
CYP2C9
DNAJB1
DTX2
ELAVL3
EXOC6
EXOSC1
FARSA
FBXL12
FBXW4
GCDH
GEM
IFIT3
IFIT5
IMMT
LONP1
LOXL4
MAGEB2
MAST1
MKRN3
NFKB1
NXF1
OGT
PAXIP1
PI4K2A
PRDX2
PSEN1
RAB3A
RAD23A
RELA
RHEB
RNF32
SETDB1
SMAD1
SMAD4
SMURF1
STAMBPL1
STRN4
TARS3
TRAF6
TRIM59
TSSK3
5 interacting genes:
A2M
APOE
ECSIT
PSEN1
SDC2
Entrez ID
51295
1562
HPRD ID
12225
03085
Ensembl ID
ENSG00000130159
ENSG00000108242
Uniprot IDs
Q9BQ95
P33260
PDB IDs
2CIK
2H6P
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Amyloid Fibril Formation
Regulation Of Protein Catabolic Process
Arachidonate Epoxygenase Activity
Lipoprotein Particle
Regulation Of MiRNA Metabolic Process
Epoxygenase P450 Pathway
NF-kappaB P50/p65 Complex
Positive Regulation Of Protein Metabolic Process
I-SMAD Binding
Cellular Response To Interleukin-6
Cytoplasm
Regulation Of Amyloid Fibril Formation
Response To Interleukin-6
Positive Regulation Of Proteolysis
Protein Metabolic Process
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Astrocyte Activation Involved In Immune Response
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen
Xenobiotic Catabolic Process
Caffeine Oxidase Activity
Magnesium Ion Binding
Response To Virus
Positive Regulation Of MiRNA Metabolic Process
Intermediate-density Lipoprotein Particle
Growth Factor Receptor Binding
Regulation Of MiRNA Transcription
Antiviral Innate Immune Response
Non-canonical NF-kappaB Signal Transduction
Regulation Of Protein Metabolic Process
SMAD Protein Complex
Neuronal Cell Body
Protein Ubiquitination
Oxidative Demethylation
Retinoic Acid 4-hydroxylase Activity
Heteromeric SMAD Protein Complex
Cellular Response To Nicotine
Protein Binding
Innate Immune Response
Cytosol
Arachidonate Metabolic Process
Omega-hydroxylase P450 Pathway
Defense Response To Virus
Defense Response To Tumor Cell
Demethylation
Protein Modification By Small Protein Conjugation
Positive Regulation Of Catabolic Process
Negative Regulation Of Long-term Synaptic Potentiation
Cellular Response To Amyloid-beta
Glutamatergic Synapse
Positive Regulation Of Amyloid Fibril Formation
Regulation Of Amyloid Fibril Formation
Amyloid Precursor Protein Metabolic Process
Enzyme Binding
Regulation Of Immune Response
Regulation Of Innate Immune Response
Extracellular Matrix
Negative Regulation Of Phospholipid Efflux
Maintenance Of Location
Negative Regulation Of Postsynaptic Membrane Organization
Positive Regulation Of Lipid Transport Across Blood-brain Barrier
Negative Regulation Of Lipid Transport Across Blood-brain Barrier
Response To Amyloid-beta
Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus
Maintenance Of Location In Cell
Positive Regulation Of Dendritic Spine Development
Cellular Response To Amyloid-beta
Regulation Of Dendritic Spine Development
Regulation Of Neuron Projection Development
Metal Chelating Activity
Intermediate-density Lipoprotein Particle Clearance
Negative Regulation Of Core Promoter Binding
PDZ Domain Binding
Negative Regulation Of Complement Activation, Lectin Pathway
Positive Regulation Of Presynaptic Membrane Organization
Chylomicron Remnant
Lipid Transport Involved In Lipid Storage
Lipoprotein Particle
Positive Regulation Of Neurofibrillary Tangle Assembly
Discoidal High-density Lipoprotein Particle
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Cajal-Retzius Cell Differentiation
Set3 Complex
Rpd3L-Expanded Complex
Blood Microparticle
Memory
Negative Regulation Of Neuron Projection Development
Myeloid Leukocyte Activation
Interleukin-8 Binding
Regulation Of Immune System Process
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process
Regulation Of Postsynapse Organization
Protein Catabolic Process At Postsynapse
Negative Regulation Of Transcription Regulatory Region DNA Binding
Regulation Of Cell Projection Organization
Blood Vessel Development
Regulation Of Postsynaptic Membrane Organization
Very-low-density Lipoprotein Particle Receptor Binding
Positive Regulation Of Phospholipid Efflux
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?