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ECSIT and EXOSC1
Number of citations of the paper that reports this interaction (PubMedID
21163940
)
58
Data Source:
BioGRID
(two hybrid)
ECSIT
EXOSC1
Description
ECSIT signaling integrator
exosome component 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Inner Membrane
Cytosol
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Nucleolar Exosome (RNase Complex)
Molecular Function
Protein Binding
Molecular Adaptor Activity
Nucleic Acid Binding
RNA Binding
RNA Exonuclease Activity
Protein Binding
Biological Process
Immune System Process
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Mitochondrial Respiratory Chain Complex I Assembly
Toll-like Receptor 4 Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Innate Immune Response
Regulation Of Oxidoreductase Activity
Regulation Of Protein Complex Stability
RRNA Processing
RNA Processing
RNA Catabolic Process
Pathways
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Complex I biogenesis
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 cascade initiated on plasma membrane
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Nuclear RNA decay
Drugs
Diseases
GWAS
Presence of antiphospholipid antibodies (
27098658
)
Blood protein levels (
30072576
)
Early spontaneous preterm birth (
31194736
)
Spontaneous preterm birth with premature rupture of membranes (
31194736
)
Interacting Genes
53 interacting genes:
A2M
AIRIM
AP1M2
APOE
APP
BFSP2
BLMH
CDC37
CEP55
CTNNA3
CYP2C18
CYP2C8
CYP2C9
DNAJB1
DTX2
ELAVL3
EXOC6
EXOSC1
FARSA
FBXL12
FBXW4
GCDH
GEM
IFIT3
IFIT5
IMMT
LONP1
LOXL4
MAGEB2
MAST1
MKRN3
NFKB1
NXF1
OGT
PAXIP1
PI4K2A
PRDX2
PSEN1
RAB3A
RAD23A
RELA
RHEB
RNF32
SETDB1
SMAD1
SMAD4
SMURF1
STAMBPL1
STRN4
TARS3
TRAF6
TRIM59
TSSK3
36 interacting genes:
A2M
APP
ASB9
CDC37
CPSF7
DDIT4L
DMRTB1
ECSIT
EXOC6
EXOSC4
EXOSC5
EXOSC7
EXOSC8
EXOSC9
FHL3
KCTD1
LNX1
LSM3
MAST1
NOS3
NUP160
PAK5
PRRC2B
PTEN
RBPMS
REL
RNF32
SF1
SH3GLB2
TCF4
TEX11
UPF2
WDR83
XRN1
ZNF143
ZNF76
Entrez ID
51295
51013
HPRD ID
12225
16223
Ensembl ID
ENSG00000130159
ENSG00000171311
Uniprot IDs
Q9BQ95
B1AMU3
Q9Y3B2
PDB IDs
2NN6
6D6Q
6D6R
6H25
9G8M
9G8N
9G8O
9G8P
Enriched GO Terms of Interacting Partners
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Positive Regulation Of Amyloid Fibril Formation
Regulation Of Protein Catabolic Process
Arachidonate Epoxygenase Activity
Lipoprotein Particle
Regulation Of MiRNA Metabolic Process
Epoxygenase P450 Pathway
NF-kappaB P50/p65 Complex
Positive Regulation Of Protein Metabolic Process
I-SMAD Binding
Cellular Response To Interleukin-6
Cytoplasm
Regulation Of Amyloid Fibril Formation
Response To Interleukin-6
Positive Regulation Of Proteolysis
Protein Metabolic Process
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Astrocyte Activation Involved In Immune Response
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen
Xenobiotic Catabolic Process
Caffeine Oxidase Activity
Magnesium Ion Binding
Response To Virus
Positive Regulation Of MiRNA Metabolic Process
Intermediate-density Lipoprotein Particle
Growth Factor Receptor Binding
Regulation Of MiRNA Transcription
Antiviral Innate Immune Response
Non-canonical NF-kappaB Signal Transduction
Regulation Of Protein Metabolic Process
SMAD Protein Complex
Neuronal Cell Body
Protein Ubiquitination
Oxidative Demethylation
Retinoic Acid 4-hydroxylase Activity
Heteromeric SMAD Protein Complex
Cellular Response To Nicotine
Protein Binding
Innate Immune Response
Cytosol
Arachidonate Metabolic Process
Omega-hydroxylase P450 Pathway
Defense Response To Virus
Defense Response To Tumor Cell
Demethylation
Protein Modification By Small Protein Conjugation
Positive Regulation Of Catabolic Process
Negative Regulation Of Long-term Synaptic Potentiation
Cellular Response To Amyloid-beta
Glutamatergic Synapse
Nuclear MRNA Surveillance
Exoribonuclease Complex
RRNA Catabolic Process
U4 SnRNA 3'-end Processing
Nucleolar Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
RNA Exonuclease Activity
Nuclear RNA Surveillance
Nuclear Exosome (RNase Complex)
Exosome (RNase Complex)
RNA Surveillance
SnRNA 3'-end Processing
Nuclear-transcribed MRNA Catabolic Process
U5 SnRNA 3'-end Processing
U1 SnRNA 3'-end Processing
SnRNA Processing
MRNA Catabolic Process
RNA 3'-end Processing
MRNA Metabolic Process
SnRNA Metabolic Process
RNA Catabolic Process
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
TRNA Surveillance
TRAMP-dependent TRNA Surveillance Pathway
Nuclear Polyadenylation-dependent RRNA Catabolic Process
MRNA 3'-UTR AU-rich Region Binding
3'-5'-RNA Exonuclease Activity
RRNA 3'-end Processing
TRNA Decay
Nucleobase-containing Compound Catabolic Process
RNA Processing
RRNA Metabolic Process
RNA Binding
RRNA Processing
Nucleus
RNA Metabolic Process
Poly(A)-dependent SnoRNA 3'-end Processing
Protein Binding
Macromolecule Catabolic Process
Negative Regulation Of Smooth Muscle Cell Proliferation
DNA Deamination
Negative Regulation Of Gene Expression
Histone MRNA Catabolic Process
Synapse Maturation
Nucleic Acid Metabolic Process
Sno(s)RNA Metabolic Process
Cytosol
Regulation Of Gene Expression
P-body
Histone MRNA Metabolic Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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