ECSIT and EXOC6

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		ECSIT	EXOC6
Gene Name		ECSIT signalling integrator	exocyst complex component 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Mitochondrion	Exocyst Cytosol Plasma Membrane
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Oxidoreductase Activity, Acting On NAD(P)H
	Biological Process	Mesoderm Formation BMP Signaling Pathway Innate Immune Response Regulation Of Oxidoreductase Activity Oxidation-reduction Process	Vesicle Docking Involved In Exocytosis Organelle Organization Protein Transport Erythrocyte Differentiation Cellular Protein Metabolic Process Membrane Organization
Pathways			Peptide hormone metabolism Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Translocation of GLUT4 to the plasma membrane VxPx cargo-targeting to cilium Assembly of the primary cilium Insulin processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		42 interactors: A2M AP1M2 APOE APP BLMH CDC37 CEP55 CYP2C18 CYP2C8 CYP2C9 DNAJB1 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH IFIT3 IFIT5 IMMT LONP1 LOXL4 MAST1 NFKB1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TRAF6 TRIM59	11 interactors: APP CYP2C8 ECSIT EXOSC1 GCDH LOXL4 MAST1 NOS3 PRDX2 PSEN2 RNF32
Entrez ID		51295	54536
HPRD ID		12225	10216
Ensembl ID		ENSG00000130159	ENSG00000138190
Uniprot IDs		K7EMM0 Q9BQ95	B3KXY5 E7EW84 F2Z2Q3 Q8TAG9
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Proteolysis Regulation Of Interleukin-12 Biosynthetic Process Cellular Response To Interleukin-1 Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Epoxygenase P450 Pathway Membrane Protein Intracellular Domain Proteolysis Catabolic Process Response To Oxidative Stress Exogenous Drug Catabolic Process Drug Catabolic Process Response To Abiotic Stimulus Response To Interleukin-1 Protein Metabolic Process Response To Stress Exocytosis Negative Regulation Of Cell Death Proteolysis Response To Stimulus T Cell Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of MiRNA Metabolic Process Drug Metabolic Process Cellular Response To Growth Factor Stimulus Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway NIK/NF-kappaB Signaling Response To Growth Factor Regulation Of Innate Immune Response Antigen Receptor-mediated Signaling Pathway Cellular Response To Nicotine Positive Regulation Of Interleukin-12 Biosynthetic Process Omega-hydroxylase P450 Pathway Cellular Response To Stimulus Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Apoptotic Process Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Programmed Cell Death Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of MiRNA Metabolic Process Negative Regulation Of Cholesterol Transport Regulation Of Interleukin-12 Production TRIF-dependent Toll-like Receptor Signaling Pathway Secretion By Cell Response To Drug SMAD Protein Complex Assembly Arachidonic Acid Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway	Oxidation-reduction Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Epidermal Growth Factor-activated Receptor Activity Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Tyrosine Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Catabolic Process Regulation Of Oxidoreductase Activity Axon Guidance Regulation Of ERBB Signaling Pathway Smooth Muscle Hyperplasia Synaptic Growth At Neuromuscular Junction Reactive Oxygen Species Metabolic Process Regulation Of Receptor Activity Cellular Amino Acid Catabolic Process Axonogenesis Locomotion Collateral Sprouting In Absence Of Injury Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Notch Signaling Pathway Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Protein Binding Smooth Muscle Adaptation Chemotaxis Anatomical Structure Morphogenesis Negative Regulation Of Muscle Hyperplasia Collateral Sprouting Regulation Of Systemic Arterial Blood Pressure By Endothelin Axon Midline Choice Point Recognition Neuron Projection Morphogenesis Movement Of Cell Or Subcellular Component Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Cell Morphogenesis Involved In Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Carboxylic Acid Catabolic Process Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Peptidyl-tyrosine Phosphorylation Lysine Catabolic Process Arginine Catabolic Process Omega-hydroxylase P450 Pathway Negative Regulation Of Cellular Protein Metabolic Process Neuron Remodeling Neuron Projection Development Exit From Mitosis Metabolic Process Cell Projection Morphogenesis Lung Development
Tagcloud ?		1beta abolished adapter attributed augments consequence cytotrap evidenced evolutionarily gst hbx hbxdelta51 helenalin hepatitis ikappabalpha ikk interacted interacting kappab knockdown mechanistically nf p50 p65 pull tlr toll transactivates transfection
Tagcloud (Difference) ?		1beta abolished adapter attributed augments consequence cytotrap evidenced evolutionarily gst hbx hbxdelta51 helenalin hepatitis ikappabalpha ikk interacted interacting kappab knockdown mechanistically nf p50 p65 pull tlr toll transactivates transfection
Tagcloud (Intersection) ?