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ECSIT and IFIT5
Number of citations of the paper that reports this interaction (PubMedID
21163940
)
58
Data Source:
BioGRID
(two hybrid)
ECSIT
IFIT5
Description
ECSIT signaling integrator
interferon induced protein with tetratricopeptide repeats 5
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Inner Membrane
Cytosol
Cytosol
Plasma Membrane
IkappaB Kinase Complex
Actin Cytoskeleton
Membrane
Ruffle Membrane
Cell Projection
Apical Part Of Cell
Molecular Function
Protein Binding
Molecular Adaptor Activity
TRNA Binding
RNA Cap Binding
Double-stranded DNA Binding
RNA Binding
Single-stranded RNA Binding
Protein Binding
Poly(U) RNA Binding
Biological Process
Immune System Process
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Mitochondrial Respiratory Chain Complex I Assembly
Toll-like Receptor 4 Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Innate Immune Response
Regulation Of Oxidoreductase Activity
Regulation Of Protein Complex Stability
Immune System Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Viral Genome Replication
Innate Immune Response
Defense Response To Virus
Pathways
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Complex I biogenesis
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 cascade initiated on plasma membrane
Interferon alpha/beta signaling
Drugs
Diseases
GWAS
Presence of antiphospholipid antibodies (
27098658
)
Interacting Genes
53 interacting genes:
A2M
AIRIM
AP1M2
APOE
APP
BFSP2
BLMH
CDC37
CEP55
CTNNA3
CYP2C18
CYP2C8
CYP2C9
DNAJB1
DTX2
ELAVL3
EXOC6
EXOSC1
FARSA
FBXL12
FBXW4
GCDH
GEM
IFIT3
IFIT5
IMMT
LONP1
LOXL4
MAGEB2
MAST1
MKRN3
NFKB1
NXF1
OGT
PAXIP1
PI4K2A
PRDX2
PSEN1
RAB3A
RAD23A
RELA
RHEB
RNF32
SETDB1
SMAD1
SMAD4
SMURF1
STAMBPL1
STRN4
TARS3
TRAF6
TRIM59
TSSK3
16 interacting genes:
A2M
APOE
CDC37
ECSIT
H19
IFIT3
LONP1
MAST1
PRDX2
PSEN2
RAD23A
RNF32
SARAF
SRPK1
SRPK2
TTC3
Entrez ID
51295
24138
HPRD ID
12225
17130
Ensembl ID
ENSG00000130159
ENSG00000152778
Uniprot IDs
Q9BQ95
Q13325
PDB IDs
3ZGQ
4HOQ
4HOR
4HOS
4HOT
4J0U
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Amyloid Fibril Formation
Regulation Of Protein Catabolic Process
Arachidonate Epoxygenase Activity
Lipoprotein Particle
Regulation Of MiRNA Metabolic Process
Epoxygenase P450 Pathway
NF-kappaB P50/p65 Complex
Positive Regulation Of Protein Metabolic Process
I-SMAD Binding
Cellular Response To Interleukin-6
Cytoplasm
Regulation Of Amyloid Fibril Formation
Response To Interleukin-6
Positive Regulation Of Proteolysis
Protein Metabolic Process
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Astrocyte Activation Involved In Immune Response
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen
Xenobiotic Catabolic Process
Caffeine Oxidase Activity
Magnesium Ion Binding
Response To Virus
Positive Regulation Of MiRNA Metabolic Process
Intermediate-density Lipoprotein Particle
Growth Factor Receptor Binding
Regulation Of MiRNA Transcription
Antiviral Innate Immune Response
Non-canonical NF-kappaB Signal Transduction
Regulation Of Protein Metabolic Process
SMAD Protein Complex
Neuronal Cell Body
Protein Ubiquitination
Oxidative Demethylation
Retinoic Acid 4-hydroxylase Activity
Heteromeric SMAD Protein Complex
Cellular Response To Nicotine
Protein Binding
Innate Immune Response
Cytosol
Arachidonate Metabolic Process
Omega-hydroxylase P450 Pathway
Defense Response To Virus
Defense Response To Tumor Cell
Demethylation
Protein Modification By Small Protein Conjugation
Positive Regulation Of Catabolic Process
Negative Regulation Of Long-term Synaptic Potentiation
Cellular Response To Amyloid-beta
Glutamatergic Synapse
Positive Regulation Of Viral Genome Replication
Positive Regulation Of Viral Process
Regulation Of Viral Genome Replication
Regulation Of Viral Life Cycle
Antioxidant Activity
Amyloid Precursor Protein Metabolic Process
Regulation Of Viral Process
Regulation Of Innate Immune Response
Negative Regulation Of Phospholipid Efflux
Negative Regulation Of Postsynaptic Membrane Organization
Positive Regulation Of Lipid Transport Across Blood-brain Barrier
Response To Stress
Negative Regulation Of Lipid Transport Across Blood-brain Barrier
Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus
Metal Chelating Activity
Intermediate-density Lipoprotein Particle Clearance
Magnesium Ion Binding
Spliceosomal Complex Assembly
Negative Regulation Of Viral Genome Replication
Respiratory Burst Involved In Inflammatory Response
Oxidation-dependent Protein Catabolic Process
Negative Regulation Of Complement Activation, Lectin Pathway
Positive Regulation Of Presynaptic Membrane Organization
Chylomicron Remnant
Lipid Transport Involved In Lipid Storage
Lipoprotein Particle
Positive Regulation Of Neurofibrillary Tangle Assembly
Discoidal High-density Lipoprotein Particle
HSP90-CDC37 Chaperone Complex
Regulation Of Blood Coagulation
Regulation Of Hemostasis
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Tagcloud (Intersection)
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