RASSF2 and PRMT6

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		RASSF2	PRMT6
Description		Ras association domain family member 2	protein arginine methyltransferase 6
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Protein-containing Complex	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protein Kinase Activity Protein Binding	Chromatin Binding Protein Binding Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone H4R3 Methyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone H3 Methyltransferase Activity
	Biological Process	Skeletal System Development Ossification Signal Transduction Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Apoptotic Process Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Bone Remodeling Homeostasis Of Number Of Cells Protein Stabilization Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Non-canonical NF-kappaB Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Base-excision Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Mitochondrion Organization Methylation Cellular Response To Stress Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways			RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Refractive error ( 32231278) Suicide attempt severity in mood disorders ( 33783297) Systemic lupus erythematosus ( 24871463)	Adult body size ( 32376654) Blood pressure measurement (low sodium intervention) ( 24165912) Intelligence ( 22449649) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Refractive error ( 32231278) Response to SSRI in MDD or openness ( 29559929) Restless legs syndrome ( 29029846) Sex hormone-binding globulin levels ( 22829776) Waist circumference ( 28552196) Weight ( 28552196)
Interacting Genes		8 interacting genes: HRAS KDM1A KRAS PRMT3 PRMT6 RASSF5 S100Z SUV39H1	90 interacting genes: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GPS2 GRHL3 GSTCD GTPBP2 H2AC18 H2BC21 H3-5 H3C14 H3C15 H4C16 H4C6 HESX1 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LINC02875 LOXL4 MALT1 MED28 METTL27 MLC1 MNDA MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PSMD11 PYCR3 PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WDFY3 ZNF436 ZNF557 ZSCAN9
Entrez ID		9770	55170
HPRD ID		15218	10505
Ensembl ID		ENSG00000101265	ENSG00000198890
Uniprot IDs		P50749	Q96LA8
PDB IDs			4HC4 4QPP 4QQK 4Y2H 4Y30 5E8R 5EGS 5HZM 5WCF 6P7I 6W6D 6WAD 7NR4
Enriched GO Terms of Interacting Partners?		Histone Methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Glial Cell Development Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Regulation Of Multicellular Organismal Process Histone H3 Methyltransferase Activity Cellular Response To Gamma Radiation Regulation Of Long-term Neuronal Synaptic Plasticity Methyltransferase Activity Protein-membrane Adaptor Activity Methylation Regulation Of Protein Ubiquitination Regulation Of Neuronal Synaptic Plasticity Response To Gamma Radiation Positive Regulation Of Gene Expression MAPK Cascade Regulation Of Cellular Senescence Positive Regulation Of Neurogenesis Positive Regulation Of Nervous System Development Ventral Spinal Cord Interneuron Fate Determination Type B Pancreatic Cell Fate Commitment Chromatin Remodeling Epigenetic Regulation Of Gene Expression Regulation Of Post-translational Protein Modification Histone H2AR3 Methyltransferase Activity Cellular Senescence Positive Regulation Of Gliogenesis Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription GDP Binding G Protein Activity Regulation Of Macromolecule Metabolic Process Cellular Response To Ionizing Radiation Regulation Of RNA Biosynthetic Process GTPase Complex Ras Protein Signal Transduction Regulation Of Multicellular Organismal Development Pancreatic A Cell Fate Commitment Pancreatic PP Cell Fate Commitment Negative Regulation Of Retinoic Acid Biosynthetic Process Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Regulation Of Cell Development Regulation Of Neurogenesis Chromatin Organization Positive Regulation Of Cell Population Proliferation Phospholipase C Activator Activity	Nucleus Structural Constituent Of Chromatin Protein Binding Nucleosome Nucleoplasm Chromatin Organization Nucleosome Organization Chromatin Remodeling Chromosome Senescence-associated Heterochromatin Focus
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?