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SELE and SERPING1
Number of citations of the paper that reports this interaction (PubMedID
14568956
)
0
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
SELE
SERPING1
Description
selectin E
serpin family G member 1
Image
GO Annotations
Cellular Component
Extracellular Space
Plasma Membrane
Caveola
Clathrin-coated Pit
External Side Of Plasma Membrane
Membrane
Cortical Cytoskeleton
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Extracellular Matrix
Platelet Alpha Granule Lumen
Extracellular Exosome
Blood Microparticle
Molecular Function
Transmembrane Signaling Receptor Activity
Protein Binding
Carbohydrate Binding
Sialic Acid Binding
Phospholipase Binding
Metal Ion Binding
Oligosaccharide Binding
Serine-type Endopeptidase Inhibitor Activity
Protein Binding
Peptidase Inhibitor Activity
Biological Process
Positive Regulation Of Receptor Internalization
Leukocyte Migration Involved In Inflammatory Response
Positive Regulation Of Leukocyte Migration
Inflammatory Response
Cell Adhesion
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Calcium-mediated Signaling
Actin Filament-based Process
Response To Lipopolysaccharide
Response To Cytokine
Response To Tumor Necrosis Factor
Regulation Of Inflammatory Response
Leukocyte Migration
Leukocyte Tethering Or Rolling
Response To Interleukin-1
Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Positive Regulation Of Leukocyte Tethering Or Rolling
Negative Regulation Of Complement Activation, Lectin Pathway
Blood Coagulation
Hemostasis
Blood Circulation
Fibrinolysis
Pathways
Cell surface interactions at the vascular wall
Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Defective SERPING1 causes hereditary angioedema
Regulation of Complement cascade
Drugs
Carvedilol
N-acetyl-alpha-neuraminic acid
Endostatin
PPL-100
Copper
Diseases
Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
Hereditary angioedema
GWAS
Blood protein levels (
30072576
)
Inflammatory bowel disease (
26192919
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
32888494
)
Autism spectrum disorder or schizophrenia (
28540026
)
Mean platelet volume (
32888494
)
Neuroticism (
29255261
)
Obesity-related traits (
23251661
)
Platelet count (
32888494
)
Schizophrenia (
25056061
29483656
)
Interacting Genes
16 interacting genes:
ACTA2
ACTN2
CD44
FLNA
GLG1
LGALS3BP
PLCG1
PTK2
PTPN11
PXN
SELL
SELPLG
SERPING1
SNCA
TRIM54
VCL
17 interacting genes:
BAG6
C1R
C1S
CFTR
ELANE
ENO1
F2
HSP90AA1
MASP1
MASP2
NR4A1
PLAT
PLG
SELE
SELP
SLC30A2
SRPK2
Entrez ID
6401
710
HPRD ID
00566
06033
Ensembl ID
ENSG00000007908
ENSG00000149131
Uniprot IDs
P16581
E9KL26
P05155
PDB IDs
1ESL
1G1T
4C16
4CSY
6EYI
6EYJ
6EYK
8R5L
8R5M
2OAY
5DU3
5DUQ
7AKV
8W18
Enriched GO Terms of Interacting Partners
?
Cell Adhesion
Cell Migration
Cytoskeleton
Focal Adhesion
Cell Motility
Cellular Response To Growth Factor Stimulus
Actin Cytoskeleton
Positive Regulation Of Cation Transmembrane Transport
Positive Regulation Of Monoatomic Ion Transmembrane Transport
Regulation Of Cytoskeleton Organization
Response To Growth Factor
Actin Binding
Regulation Of Supramolecular Fiber Organization
Leukocyte Cell-cell Adhesion
Cell Cortex
Positive Regulation Of Monoatomic Ion Transport
Signal Complex Assembly
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Stress Fiber
Cell Projection
Cell-cell Adhesion
Regulation Of Monoatomic Cation Transmembrane Transport
Positive Regulation Of Fibroblast Migration
Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Cellular Component Organization
Immune System Process
Regulation Of Monoatomic Ion Transmembrane Transport
Leukocyte Tethering Or Rolling
Megakaryocyte Development
Leukocyte Adhesion To Vascular Endothelial Cell
Extracellular Exosome
Regulation Of Metal Ion Transport
Z Disc
Regulation Of Sequestering Of Calcium Ion
Enzyme-linked Receptor Protein Signaling Pathway
Growth Hormone Receptor Signaling Pathway
Regulation Of Locomotion
Wound Healing, Spreading Of Cells
Regulation Of Actin Filament-based Process
Cellular Response To Fibroblast Growth Factor Stimulus
Protein Localization To Cell Surface
Cell-substrate Adhesion
Regulation Of Multicellular Organismal Process
Protein-containing Complex
Positive Regulation Of Supramolecular Fiber Organization
Positive Regulation Of Potassium Ion Transport
Regulation Of Organelle Organization
Plasma Membrane
Regulation Of Monoatomic Ion Transport
Serine-type Peptidase Activity
Serine-type Endopeptidase Activity
Response To External Biotic Stimulus
Zymogen Activation
Activation Of Membrane Attack Complex
Immune System Process
Killing Of Cells Of Another Organism
Opsonization
Symbiont Cell Surface
Peptidase Activity
Extracellular Space
Protein Processing
Response To Other Organism
Response To Stress
Cell Killing
Cell Surface
Positive Regulation Of Leukocyte Tethering Or Rolling
Defense Response
Positive Regulation Of Immune System Process
Negative Regulation Of Fibrinolysis
Complement Activation
Regulation Of Leukocyte Tethering Or Rolling
Protein Maturation
Proteolysis
Regulation Of Fibrinolysis
Fibrinolysis
Immune Effector Process
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of Immune Response
Activation Of Immune Response
Positive Regulation Of Blood Coagulation
Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission
Positive Regulation Of Coagulation
Defense Response To Symbiont
Humoral Immune Response
Defense Response To Other Organism
Complement Activation, Classical Pathway
Blood Microparticle
Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Regulation Of Cellular Extravasation
Lipopolysaccharide Binding
Trans-synaptic Signaling By BDNF
Regulation Of Immune System Process
Extracellular Region
Biological Process Involved In Interaction With Symbiont
Hydrolase Activity
Complement Component C1 Complex
Neutrophil-mediated Killing Of Gram-negative Bacterium
Cell Migration
Negative Regulation Of Blood Coagulation
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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