SELE and TRIM54

Number of citations of the paper that reports this interaction (PubMedID 31391242)
0

Data Source:
BioGRID (two hybrid)

		SELE	TRIM54
Description		selectin E	tripartite motif containing 54
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Caveola Clathrin-coated Pit External Side Of Plasma Membrane Membrane Cortical Cytoskeleton Membrane Raft Perinuclear Region Of Cytoplasm	Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Z Disc
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Carbohydrate Binding Sialic Acid Binding Phospholipase Binding Metal Ion Binding Oligosaccharide Binding	Protein Binding Microtubule Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Receptor Internalization Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Leukocyte Migration Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Calcium-mediated Signaling Actin Filament-based Process Response To Lipopolysaccharide Response To Cytokine Response To Tumor Necrosis Factor Regulation Of Inflammatory Response Leukocyte Migration Leukocyte Tethering Or Rolling Response To Interleukin-1 Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Leukocyte Tethering Or Rolling	Microtubule-based Process Negative Regulation Of Microtubule Depolymerization Signal Transduction Cell Differentiation Innate Immune Response
Pathways		Cell surface interactions at the vascular wall
Drugs		Carvedilol N-acetyl-alpha-neuraminic acid Endostatin
Diseases
GWAS		Blood protein levels ( 30072576) Inflammatory bowel disease ( 26192919) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494)	Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		16 interacting genes: ACTA2 ACTN2 CD44 FLNA GLG1 LGALS3BP PLCG1 PTK2 PTPN11 PXN SELL SELPLG SERPING1 SNCA TRIM54 VCL	318 interacting genes: AAMDC ABHD17C ADCY4 AGFG1 AIRIM AK2 AK3 ANKRD11 ANKRD45 ARFIP2 ARHGAP29 ARHGEF5 ARHGEF6 ARMC7 ATXN3 ATXN3L ATXN7 BBX BMF BSCL2 BYSL C14orf39 C1orf216 C1orf35 C1QTNF2 C2orf49 C8orf74 CALM3 CARD9 CATSPERT CAVIN2 CBX8 CCDC102B CCDC146 CCDC17 CCDC187 CCDC26 CCDC28A CCDC87 CCHCR1 CCNC CDC37 CDK18 CDKAL1 CDKN1A CENPX CEP57L1 CEP68 CFAP100 CFAP206 CFAP53 CHCHD2 CHD2 CHD3 CKM CLPP CMIP CNGA3 CRADD CSNK2B CTNNA3 CWF19L2 CYTH4 DAXX DCAF8 DCLRE1B DCUN1D1 DDX6 DEUP1 DNAL4 DNASE1L1 DPYSL4 DRC4 DRG2 DTNB DTX2 DUSP16 DVL3 DYNC2I2 DYNLL1 EHHADH EIF4E2 ELMO1 ELOA ENKD1 EPHB2 EPM2AIP1 EXOC7 EXOC8 EXOSC5 EXTL2 FAM110A FAM124A FAM124B FAM161A FAM50B FAM90A1 FAM9A FARS2 FBF1 FBXO16 FBXW2 FLNC FMNL1 G2E3 GEM GIMAP2 GLP2R GMCL1 GNG13 GNL3L GTF2I GTF2IRD2 GTF2IRD2B HAUS1 HBG1 HDAC10 HGS HMMR HOXB5 HSF2 HSPB1 HYAL2 IL18RAP IL36A IL4I1 ING3 INPP5J IQUB ITGAE ITPKB JOSD1 KANK2 KAT14 KDM1A KIF9 KIFC3 KLHL38 KLHL42 KPNA2 KRT1 KRT3 KRT4 KRT6A KRT6B KRT6C KRT75 KRT76 KRT78 KRT79 KRT8 KRTAP11-1 KRTAP9-2 LENG1 LIN37 LINC00887 LMO1 LMO2 LMO3 LMO4 LNX1 LSM2 MAD2L2 MAOB MAPK3 MBD3 MCM7 MEAF6 MFAP1 MGARP MICAL2 MID2 MNS1 MRTFA MSH5 MYLK2 MYO15B MYO5B NEK6 NGLY1 NTAQ1 NUP54 NUP58 OFCC1 OSGIN1 OSTF1 OTUB1 OTUB2 PABPC3 PAIP2 PARVG PCDHGB1 PCDHGC3 PCSK7 PDZK1IP1 PICK1 PIK3R3 PIWIL1 PLEKHM1 PLK4 PPIG PPP1R18 PRF1 PRKAB2 PRKG1 PRMT5 PRPF18 PRR35 PSMA1 PYGM RAB35 RABGEF1 RAD23A RAPSN RASSF10 RBM15B RBM41 RCOR3 RELT RIMS3 RNF4 RSRC2 RUNX1T1 SCNM1 SDCBP SEC14L4 SELE SEMA4C SENP3 SH2D1B SHC3 SLC13A2 SLITRK3 SMARCD1 SMARCE1 SNF8 SOX14 SPG21 SPRING1 SSX2IP STAM STRC STXBP4 STYXL1 SYCE3 SYTL5 TBC1D22B TCAF1 TCAP TCEA2 TCEANC TCHP TEAD4 TEPSIN THAP4 THOC1 TJAP1 TLE6 TLR10 TMEM30A TNFAIP1 TNR TRIM55 TRIM63 TRIM69 TRIML2 TSG101 TSHZ3 TSPEAR TSSK3 TTC23 TTC9C TTN UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2N UBE2U UBE2V2 UBL4A UCHL1 UCHL3 UCHL5 USHBP1 USP15 USP18 USP2 USP21 USP33 USP35 USP4 USP5 USP7 USP8 UTP14C VAMP4 VCAM1 VCP VPS28 VPS9D1 XAF1 YEATS4 YOD1 ZBTB16 ZFHX3 ZGPAT ZNF180 ZNF182 ZNF250 ZNF267 ZNF366 ZNF417 ZNF572 ZNF587 ZNF667-AS1
Entrez ID		6401	57159
HPRD ID		00566	05928
Ensembl ID		ENSG00000007908	ENSG00000138100
Uniprot IDs		P16581	Q9BYV2
PDB IDs		1ESL 1G1T 4C16 4CSY 6EYI 6EYJ 6EYK 8R5L 8R5M	3Q1D
Enriched GO Terms of Interacting Partners?		Cell Adhesion Cell Migration Cytoskeleton Focal Adhesion Cell Motility Cellular Response To Growth Factor Stimulus Actin Cytoskeleton Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Cytoskeleton Organization Response To Growth Factor Actin Binding Regulation Of Supramolecular Fiber Organization Leukocyte Cell-cell Adhesion Cell Cortex Positive Regulation Of Monoatomic Ion Transport Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Stress Fiber Cell Projection Cell-cell Adhesion Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Fibroblast Migration Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Component Organization Immune System Process Regulation Of Monoatomic Ion Transmembrane Transport Leukocyte Tethering Or Rolling Megakaryocyte Development Leukocyte Adhesion To Vascular Endothelial Cell Extracellular Exosome Regulation Of Metal Ion Transport Z Disc Regulation Of Sequestering Of Calcium Ion Enzyme-linked Receptor Protein Signaling Pathway Growth Hormone Receptor Signaling Pathway Regulation Of Locomotion Wound Healing, Spreading Of Cells Regulation Of Actin Filament-based Process Cellular Response To Fibroblast Growth Factor Stimulus Protein Localization To Cell Surface Cell-substrate Adhesion Regulation Of Multicellular Organismal Process Protein-containing Complex Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Potassium Ion Transport Regulation Of Organelle Organization Plasma Membrane Regulation Of Monoatomic Ion Transport	Cysteine-type Deubiquitinase Activity Protein Binding Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Keratin Filament Post-translational Protein Modification Ubiquitin Binding Cytosol Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Protein Modification Process Intermediate Filament-based Process Protein K48-linked Deubiquitination Keratinization Organelle Organization Cytoplasm Intermediate Filament Ubiquitin Conjugating Enzyme Activity Centrosome Positive Regulation Of Exosomal Secretion Deubiquitinase Activity Cytoskeleton Organization Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway K48-linked Deubiquitinase Activity Ubiquitin-dependent Protein Catabolic Process Membrane Fission Regulation Of Exosomal Secretion Modification-dependent Protein Catabolic Process Nucleoplasm Negative Regulation Of TORC1 Signaling Regulation Of DNA Repair Peptidase Activity Nucleus Proteolysis Microtubule-based Process Regulation Of DNA Metabolic Process Positive Regulation Of DNA Repair Regulation Of Cellular Response To Stress Proteolysis Involved In Protein Catabolic Process Protein K63-linked Deubiquitination Regulation Of Double-strand Break Repair Endosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Extracellular Exosome Assembly DeNEDDylase Activity Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Cytoskeleton Microtubule-based Movement Endosome Organization
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