SELE and SELL

Number of citations of the paper that reports this interaction (PMID 9024699)
24

Data Source:
HPRD (in vitro)

		SELE	SELL
Gene Name		selectin E	selectin L
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Caveola Coated Pit Integral Component Of Membrane Cortical Cytoskeleton Membrane Raft Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Sialic Acid Binding Phospholipase Binding Oligosaccharide Binding	Protease Binding Protein Binding Heparin Binding Carbohydrate Binding Glycosphingolipid Binding Cell Adhesion Molecule Binding
	Biological Process	Positive Regulation Of Receptor Internalization Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Leukocyte Migration Inflammatory Response Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Activation Of Phospholipase C Activity Blood Coagulation Calcium-mediated Signaling Actin Filament-based Process Response To Lipopolysaccharide Response To Tumor Necrosis Factor Regulation Of Inflammatory Response Leukocyte Migration Leukocyte Tethering Or Rolling Response To Interleukin-1	Cell Adhesion Blood Coagulation Response To ATP Regulation Of Immune Response Leukocyte Migration
Pathways		Cell surface interactions at the vascular wall	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Adaptive Immune System
Drugs		O-Sialic Acid
Diseases
GWAS			Amyotrophic lateral sclerosis ( 19451621)
Protein-Protein Interactions		13 interactors: ACTN2 CD44 FLNA GLG1 LGALS3BP PLCG1 PTK2 PTPN11 PXN SELL SELPLG SERPING1 VCL	15 interactors: CD4 CFH EMCN EZR GRB2 MSN MUC7 PODXL PODXL2 PRKCA PRKCQ PRKG1 SELE SELPLG VCAN
Entrez ID		6401	6402
HPRD ID		00566	07034
Ensembl ID		ENSG00000007908	ENSG00000188404
Uniprot IDs		P16581	P14151
PDB IDs		1ESL 1G1T 1KJA	1KJB 2LGF 3CFW
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Response To Stress Movement Of Cell Or Subcellular Component Leukocyte Migration Cell Adhesion Platelet Activation Platelet Degranulation Cell Migration Cell Motility Cell Projection Organization Cell Activation Cell Morphogenesis Involved In Differentiation Response To Stimulus Locomotion Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell-matrix Adhesion Adherens Junction Assembly Positive Regulation Of Intracellular Signal Transduction Cell Junction Assembly Vesicle-mediated Transport Cell-substrate Adhesion Immune System Process Regulation Of Protein Metabolic Process Signal Complex Assembly Anatomical Structure Morphogenesis Cellular Response To Growth Factor Stimulus Cell Morphogenesis Response To Growth Factor Adherens Junction Organization Cell Projection Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Exocytosis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Defense Response Integrin-mediated Signaling Pathway Innate Immune Response Protein Localization To Cell Surface Cell Projection Morphogenesis Regulation Of Signaling Cell Part Morphogenesis Positive Regulation Of Phosphorylation Regulation Of Immune Response Positive Regulation Of MAPK Cascade	Locomotion Movement Of Cell Or Subcellular Component Leukocyte Migration Cell Migration Cell Motility Cell Adhesion Leukocyte Cell-cell Adhesion Immune System Process Regulation Of Cell-cell Adhesion Leukocyte Tethering Or Rolling Blood Coagulation Hemostasis Regulation Of Platelet Aggregation Single Organismal Cell-cell Adhesion Regulation Of Body Fluid Levels Cellular Extravasation Wound Healing Regulation Of Platelet Activation Regulation Of Cell Adhesion Response To Wounding Positive Regulation Of Cell Adhesion Membrane To Membrane Docking Regulation Of Immune System Process Regulation Of Cell Activation Positive Regulation Of Immune System Process Positive Regulation Of Cell-cell Adhesion Cell Differentiation Regulation Of Blood Coagulation Cell Activation Positive Regulation Of Interleukin-2 Biosynthetic Process Regulation Of Wound Healing Defense Response Innate Immune Response Cellular Response To Radiation Regulation Of Interleukin-2 Biosynthetic Process Regulation Of Rhodopsin Mediated Signaling Pathway Establishment Of Endothelial Barrier Rhodopsin Mediated Signaling Pathway Platelet Activation Positive Regulation Of Interleukin-2 Production Positive Regulation Of T Cell Activation Epithelial Cell Development Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Response To Stress Receptor Internalization Regulation Of Cell Migration Chemotaxis Cell Development Response To External Stimulus
Tagcloud ?		2000bp 500bp annotated cor cst11 cyp2b13 cyp2b9 cyp2d9 cyp3a41 cyp3a44 cyp4a10 cyp7b1 ddc defb43 esr2 fmo3 hsd3b5 hypo masculinization masculinize methylatable nimblegen permanently slco1a1 sult2a2 tss ugt2b1 ugt2b38 unmethylated	aw cereal cereals consignments contents corrected damaged dry heterogeneity ill infestation insects inspection kernels mould overseas portion prompt safe shipments shipped storage substance substantiated substituted theoretical trade usefully validity
Tagcloud (Difference) ?		2000bp 500bp annotated cor cst11 cyp2b13 cyp2b9 cyp2d9 cyp3a41 cyp3a44 cyp4a10 cyp7b1 ddc defb43 esr2 fmo3 hsd3b5 hypo masculinization masculinize methylatable nimblegen permanently slco1a1 sult2a2 tss ugt2b1 ugt2b38 unmethylated	aw cereal cereals consignments contents corrected damaged dry heterogeneity ill infestation insects inspection kernels mould overseas portion prompt safe shipments shipped storage substance substantiated substituted theoretical trade usefully validity
Tagcloud (Intersection) ?