SELE and SELL

Number of citations: 49 (PubMedID 9024699)
Data Source: HPRD (in vitro)

		SELE	SELL
Name		selectin E	selectin L
Structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Caveola Clathrin-coated Pit External Side Of Plasma Membrane Membrane Cortical Cytoskeleton Membrane Raft Perinuclear Region Of Cytoplasm	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Carbohydrate Binding Sialic Acid Binding Phospholipase Binding Metal Ion Binding Oligosaccharide Binding	Protease Binding Calcium Ion Binding Protein Binding Heparin Binding Carbohydrate Binding Sialic Acid Binding Glycosphingolipid Binding Metal Ion Binding Oligosaccharide Binding
	Biological Process	Positive Regulation Of Receptor Internalization Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Leukocyte Migration Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Calcium-mediated Signaling Actin Filament-based Process Response To Lipopolysaccharide Response To Cytokine Response To Tumor Necrosis Factor Regulation Of Inflammatory Response Leukocyte Migration Leukocyte Tethering Or Rolling Response To Interleukin-1 Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Leukocyte Tethering Or Rolling	Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Cytokine Leukocyte Migration Leukocyte Tethering Or Rolling Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Pathways		Cell surface interactions at the vascular wall	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Neutrophil degranulation
Drugs		Carvedilol N-acetyl-alpha-neuraminic acid Endostatin	None
GWAS		Blood protein levels ( 30072576 ) Inflammatory bowel disease ( 26192919 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 )	Acne (severe) ( 24399259 ) Amyotrophic lateral sclerosis ( 19451621 ) Basophil percentage of white cells ( 32888494 ) Blood protein levels ( 30072576 ) Eosinophil percentage of white cells ( 32888494 ) Inflammatory bowel disease ( 26192919 ) L-selectin levels ( 25576479 ) Monocyte count ( 32888494 )
Interacting Genes		16 interacting genes: ACTA2 ACTN2 CD44 FLNA GLG1 LGALS3BP PLCG1 PTK2 PTPN11 PXN SELL SELPLG SERPING1 SNCA TRIM54 VCL	16 interacting genes: CD4 CFH EMCN EZR GRB2 MSN MUC7 PODXL PODXL2 PRKCA PRKCQ PRKG1 SELE SELPLG SLC30A2 VCAN
Entrez ID		6401	6402
HPRD ID		00566	07034
Ensembl ID		ENSG00000007908	ENSG00000188404
Uniprot IDs		P16581	P14151
PDB IDs		1ESL 1G1T 4C16 4CSY 6EYI 6EYJ 6EYK 8R5L 8R5M	2LGF 3CFW 5VC1
GO Terms Enriched among Interactors		Cell Adhesion Cell Migration Cytoskeleton Focal Adhesion Cell Motility Cellular Response To Growth Factor Stimulus Actin Cytoskeleton Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Cytoskeleton Organization Response To Growth Factor Actin Binding Regulation Of Supramolecular Fiber Organization Leukocyte Cell-cell Adhesion Cell Cortex Positive Regulation Of Monoatomic Ion Transport Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Stress Fiber Cell Projection Cell-cell Adhesion Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Fibroblast Migration Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Component Organization Immune System Process Regulation Of Monoatomic Ion Transmembrane Transport Leukocyte Tethering Or Rolling Megakaryocyte Development Leukocyte Adhesion To Vascular Endothelial Cell Extracellular Exosome Regulation Of Metal Ion Transport Z Disc Regulation Of Sequestering Of Calcium Ion Enzyme-linked Receptor Protein Signaling Pathway Growth Hormone Receptor Signaling Pathway Regulation Of Locomotion Wound Healing, Spreading Of Cells Regulation Of Actin Filament-based Process Cellular Response To Fibroblast Growth Factor Stimulus Protein Localization To Cell Surface Cell-substrate Adhesion Regulation Of Multicellular Organismal Process Protein-containing Complex Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Potassium Ion Transport Regulation Of Organelle Organization Plasma Membrane Regulation Of Monoatomic Ion Transport	Leukocyte Cell-cell Adhesion Cell Adhesion Regulation Of Cell-cell Adhesion Uropod Plasma Membrane Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Microvillus Membrane Regulation Of Platelet Aggregation Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Cell Migration Membrane To Membrane Docking Positive Regulation Of Cell-cell Adhesion Regulation Of Platelet Activation Cell Motility Regulation Of Interleukin-2 Production Positive Regulation Of Early Endosome To Late Endosome Transport Microvillus Regulation Of Immune System Process Positive Regulation Of Protein Localization To Early Endosome Filopodium Positive Regulation Of Protein Localization To Endosome Cell-cell Adhesion Positive Regulation Of Leukocyte Cell-cell Adhesion Immune System Process Golgi Lumen Establishment Of Epithelial Cell Apical/basal Polarity Diacylglycerol-dependent Serine/threonine Kinase Activity Leukocyte Activation Regulation Of Early Endosome To Late Endosome Transport T Cell Activation Establishment Of Apical/basal Cell Polarity Positive Regulation Of Immune System Process Regulation Of Cell Activation Glycosaminoglycan Binding Epithelial Cell Development Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Cell Activation Cortical Cytoskeleton Gland Morphogenesis Establishment Of Epithelial Cell Polarity Regulation Of Leukocyte Cell-cell Adhesion Signaling Receptor Binding Actin Filament-based Process Plasma Membrane Raft Positive Regulation Of Interleukin-2 Production Establishment Of Endothelial Barrier