SELE and SELPLG

Number of citations of the paper that reports this interaction (PMID 8621728)
54

Data Source:
HPRD (in vitro, in vivo)

		SELE	SELPLG
Gene Name		selectin E	selectin P ligand
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Caveola Coated Pit Integral Component Of Membrane Cortical Cytoskeleton Membrane Raft Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Sialic Acid Binding Phospholipase Binding Oligosaccharide Binding	Receptor Binding Protein Binding
	Biological Process	Positive Regulation Of Receptor Internalization Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Leukocyte Migration Inflammatory Response Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Activation Of Phospholipase C Activity Blood Coagulation Calcium-mediated Signaling Actin Filament-based Process Response To Lipopolysaccharide Response To Tumor Necrosis Factor Regulation Of Inflammatory Response Leukocyte Migration Leukocyte Tethering Or Rolling Response To Interleukin-1	Cell Adhesion Blood Coagulation Leukocyte Migration Leukocyte Tethering Or Rolling Leukocyte Adhesive Activation Cellular Response To Interleukin-6
Pathways		Cell surface interactions at the vascular wall	Cell surface interactions at the vascular wall
Drugs		O-Sialic Acid
Diseases
GWAS			Conduct disorder (symptom count) ( 20585324)
Protein-Protein Interactions		13 interactors: ACTN2 CD44 FLNA GLG1 LGALS3BP PLCG1 PTK2 PTPN11 PXN SELL SELPLG SERPING1 VCL	13 interactors: BACE1 CTSG GALNT4 MAGEA1 MSN SELE SELL SELP SYK TNIP1 TPST1 TPST2 VCAN
Entrez ID		6401	6404
HPRD ID		00566	02845
Ensembl ID		ENSG00000007908	ENSG00000110876
Uniprot IDs		P16581	Q14242
PDB IDs		1ESL 1G1T 1KJA	1G1S
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Response To Stress Movement Of Cell Or Subcellular Component Leukocyte Migration Cell Adhesion Platelet Activation Platelet Degranulation Cell Migration Cell Motility Cell Projection Organization Cell Activation Cell Morphogenesis Involved In Differentiation Response To Stimulus Locomotion Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell-matrix Adhesion Adherens Junction Assembly Positive Regulation Of Intracellular Signal Transduction Cell Junction Assembly Vesicle-mediated Transport Cell-substrate Adhesion Immune System Process Regulation Of Protein Metabolic Process Signal Complex Assembly Anatomical Structure Morphogenesis Cellular Response To Growth Factor Stimulus Cell Morphogenesis Response To Growth Factor Adherens Junction Organization Cell Projection Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Exocytosis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Defense Response Integrin-mediated Signaling Pathway Innate Immune Response Protein Localization To Cell Surface Cell Projection Morphogenesis Regulation Of Signaling Cell Part Morphogenesis Positive Regulation Of Phosphorylation Regulation Of Immune Response Positive Regulation Of MAPK Cascade	Leukocyte Migration Peptidyl-tyrosine Sulfation Leukocyte Cell-cell Adhesion Cell Adhesion Regulation Of Immune System Process Inflammatory Response Cell Migration Protein Sulfation Cell Motility Single Organismal Cell-cell Adhesion Leukocyte Tethering Or Rolling Sulfation Locomotion Regulation Of Leukocyte Migration Defense Response Immune System Process Blood Coagulation Hemostasis Movement Of Cell Or Subcellular Component Positive Regulation Of Immune System Process Response To Bacterium Cellular Extravasation Regulation Of Platelet Activation Defense Response To Bacterium Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Regulation Of Body Fluid Levels Response To Fungus Wound Healing Response To Wounding Response To Other Organism Response To Biotic Stimulus Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Response To Lipopolysaccharide Platelet Degranulation Response To Molecule Of Bacterial Origin Sulfur Compound Metabolic Process Regulation Of Immune Response Response To Stress Positive Regulation Of Leukocyte Migration Glycoprotein Biosynthetic Process Cellular Response To Molecule Of Fungal Origin Neutrophil Mediated Killing Of Gram-positive Bacterium Beta Selection Selenium Compound Metabolic Process Positive Regulation Of Interleukin-3 Biosynthetic Process Regulation Of Blood Coagulation Glycoprotein Metabolic Process Serotonin Secretion By Platelet Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Prevention Of Polyspermy
Tagcloud ?		2000bp 500bp annotated cor cst11 cyp2b13 cyp2b9 cyp2d9 cyp3a41 cyp3a44 cyp4a10 cyp7b1 ddc defb43 esr2 fmo3 hsd3b5 hypo masculinization masculinize methylatable nimblegen permanently slco1a1 sult2a2 tss ugt2b1 ugt2b38 unmethylated	aggregates allele angioplasty atherothrombosis carrier carriers depended glycoprotein ile62 inducible irrespective leukocyte lpa monocyte mpa npa pivotal platelet pp pro715 psgl selectin sp stenting stronger thrombin trap variations
Tagcloud (Difference) ?		2000bp 500bp annotated cor cst11 cyp2b13 cyp2b9 cyp2d9 cyp3a41 cyp3a44 cyp4a10 cyp7b1 ddc defb43 esr2 fmo3 hsd3b5 hypo masculinization masculinize methylatable nimblegen permanently slco1a1 sult2a2 tss ugt2b1 ugt2b38 unmethylated	aggregates allele angioplasty atherothrombosis carrier carriers depended glycoprotein ile62 inducible irrespective leukocyte lpa monocyte mpa npa pivotal platelet pp pro715 psgl selectin sp stenting stronger thrombin trap variations
Tagcloud (Intersection) ?