SELE and FLNA

Number of citations of the paper that reports this interaction (PubMedID 8609175)
49

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		SELE	FLNA
Description		selectin E	filamin A
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Caveola Clathrin-coated Pit External Side Of Plasma Membrane Membrane Cortical Cytoskeleton Membrane Raft Perinuclear Region Of Cytoplasm	Podosome Extracellular Region Nucleus Nucleolus Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Z Disc Growth Cone Cortical Cytoskeleton Myb Complex Cell Projection Neuronal Cell Body Dendritic Shaft Perikaryon Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Apical Dendrite Postsynapse Glutamatergic Synapse Glycoprotein Ib-IX-V Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Carbohydrate Binding Sialic Acid Binding Phospholipase Binding Metal Ion Binding Oligosaccharide Binding	G Protein-coupled Receptor Binding RNA Binding Actin Binding Protein Binding Potassium Channel Regulator Activity Kinase Binding Small GTPase Binding Fc-gamma Receptor I Complex Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein-containing Complex Binding Cadherin Binding SMAD Binding Actin Filament Binding GTPase Binding DNA-binding Transcription Factor Binding Protein Sequestering Activity
	Biological Process	Positive Regulation Of Receptor Internalization Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Leukocyte Migration Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Calcium-mediated Signaling Actin Filament-based Process Response To Lipopolysaccharide Response To Cytokine Response To Tumor Necrosis Factor Regulation Of Inflammatory Response Leukocyte Migration Leukocyte Tethering Or Rolling Response To Interleukin-1 Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Leukocyte Tethering Or Rolling	Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Blood Coagulation, Intrinsic Pathway Positive Regulation Of Platelet Activation Negative Regulation Of Transcription By RNA Polymerase I Formation Of Radial Glial Scaffolds Cerebral Cortex Development Cell Projection Organization Actin Cytoskeleton Organization Regulation Of Cell Migration Positive Regulation Of Actin Filament Bundle Assembly Protein Localization To Cell Surface Megakaryocyte Development Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus MRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA-binding Transcription Factor Activity Wound Healing, Spreading Of Cells Establishment Of Protein Localization Protein Stabilization Release Of Sequestered Calcium Ion Into Cytosol Actin Crosslink Formation Cilium Assembly Platelet Aggregation Semaphorin-plexin Signaling Pathway Protein Localization To Plasma Membrane Tubulin Deacetylation Mitotic Spindle Assembly Establishment Of Sertoli Cell Barrier Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Potassium Ion Transmembrane Transport Protein Localization To Bicellular Tight Junction Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Neuron Migration
Pathways		Cell surface interactions at the vascular wall	Platelet degranulation GP1b-IX-V activation signalling Cell-extracellular matrix interactions RHO GTPases activate PAKs OAS antiviral response
Drugs		Carvedilol N-acetyl-alpha-neuraminic acid Endostatin	Artenimol
Diseases			FG syndrome (FGS); Opitz-Kaveggia syndrome Periventricular nodular heterotopia (PVNH) Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia
GWAS		Blood protein levels ( 30072576) Inflammatory bowel disease ( 26192919) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494)	Immature fraction of reticulocytes ( 32888494) White blood cell count ( 32888494)
Interacting Genes		16 interacting genes: ACTA2 ACTN2 CD44 FLNA GLG1 LGALS3BP PLCG1 PTK2 PTPN11 PXN SELL SELPLG SERPING1 SNCA TRIM54 VCL	106 interacting genes: ADAMTSL4 ANKRD13C-DT APC AR ARHGAP24 ARRB1 ARRB2 ASB2 BRCA1 BRCA2 CALCR CAMK2G CASR CAV1 CCNB1 CDC42 CDK1 CEACAM1 CEBPA CFL1 CMIP DCN DDIT4L DRD1 DRD2 DRD3 DUX4 ERBB3 F3 FABP1 FBLIM1 FILIP1 FLNB FURIN GP1BA GRIK1 GRIK3 GRM4 GRM5 GRM7 GRM8 HMGB2 HNRNPD HSPA6 ITGB1 ITGB3 ITGB5 ITGB6 ITGB7 KCNE4 KCNJ2 KLHL12 LGALS14 LMNA MAP2K4 MAPK14 MCPH1 MTDH MTNR1A MTNR1B MTOR MYOT MYOZ1 NLGN3 NPHP1 OPRM1 PAK1 PCBP2 PDE4B PELO PHOSPHO2 PLEKHF2 PRKCA PSEN1 PSEN2 PTEN RAC1 RALA REL RFLNA RHOA RNF10 SELE SH2B3 SHBG SIGLEC10 SIRPA SMAD3 SMAD5 SPANXD SRC SUMO2 SVIL SYNPO2 TCF4 TLR10 TNIP2 TP73 TRAF2 TRIM55 TRIO TTN USP19 VHL XIAP YWHAG
Entrez ID		6401	2316
HPRD ID		00566	02060
Ensembl ID		ENSG00000007908	ENSG00000196924
Uniprot IDs		P16581	P21333 Q60FE5 Q6NXF2
PDB IDs		1ESL 1G1T 4C16 4CSY 6EYI 6EYJ 6EYK 8R5L 8R5M	2AAV 2BP3 2BRQ 2J3S 2JF1 2K3T 2K7P 2K7Q 2MTP 2W0P 2WFN 3CNK 3HOC 3HOP 3HOR 3ISW 3RGH 4M9P 4P3W 5XR1 6D8C 6EW1 7SC4 7SFT 9LWX 9LXG
Enriched GO Terms of Interacting Partners?		Cell Adhesion Cell Migration Cytoskeleton Focal Adhesion Cell Motility Cellular Response To Growth Factor Stimulus Actin Cytoskeleton Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Cytoskeleton Organization Response To Growth Factor Actin Binding Regulation Of Supramolecular Fiber Organization Leukocyte Cell-cell Adhesion Cell Cortex Positive Regulation Of Monoatomic Ion Transport Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Stress Fiber Cell Projection Cell-cell Adhesion Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Fibroblast Migration Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Component Organization Immune System Process Regulation Of Monoatomic Ion Transmembrane Transport Leukocyte Tethering Or Rolling Megakaryocyte Development Leukocyte Adhesion To Vascular Endothelial Cell Extracellular Exosome Regulation Of Metal Ion Transport Z Disc Regulation Of Sequestering Of Calcium Ion Enzyme-linked Receptor Protein Signaling Pathway Growth Hormone Receptor Signaling Pathway Regulation Of Locomotion Wound Healing, Spreading Of Cells Regulation Of Actin Filament-based Process Cellular Response To Fibroblast Growth Factor Stimulus Protein Localization To Cell Surface Cell-substrate Adhesion Regulation Of Multicellular Organismal Process Protein-containing Complex Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Potassium Ion Transport Regulation Of Organelle Organization Plasma Membrane Regulation Of Monoatomic Ion Transport	Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Intracellular Signaling Cassette Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Migration Regulation Of Biological Quality Regulation Of Synaptic Transmission, Glutamatergic Focal Adhesion Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Positive Regulation Of Developmental Process Cellular Response To Oxygen-containing Compound Regulation Of Developmental Process Cell Motility Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Cellular Component Organization Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Regulation Of System Process Regulation Of Membrane Potential Glutamatergic Synapse Enzyme Binding Positive Regulation Of MAPK Cascade Plasma Membrane Response To Stress Regulation Of Transport Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Differentiation Cell Junction Organization Positive Regulation Of Locomotion Actin Filament-based Process
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