SELE and PXN

Number of citations of the paper that reports this interaction (PMID 8609175)
23

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		SELE	PXN
Gene Name		selectin E	paxillin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Caveola Coated Pit Integral Component Of Membrane Cortical Cytoskeleton Membrane Raft Perinuclear Region Of Cytoplasm	Stress Fiber Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Sialic Acid Binding Phospholipase Binding Oligosaccharide Binding	Integrin Binding Protein Binding Beta-catenin Binding Zinc Ion Binding Vinculin Binding Protein Kinase Binding BH4 Domain Binding
	Biological Process	Positive Regulation Of Receptor Internalization Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Leukocyte Migration Inflammatory Response Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Activation Of Phospholipase C Activity Blood Coagulation Calcium-mediated Signaling Actin Filament-based Process Response To Lipopolysaccharide Response To Tumor Necrosis Factor Regulation Of Inflammatory Response Leukocyte Migration Leukocyte Tethering Or Rolling Response To Interleukin-1	Activation Of MAPK Activity Movement Of Cell Or Subcellular Component Muscle Contraction Cytoskeleton Organization Cell Adhesion Signal Transduction Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cell Shape Peptidyl-tyrosine Phosphorylation Lamellipodium Assembly Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Vascular Endothelial Growth Factor Receptor Signaling Pathway Focal Adhesion Assembly Branching Morphogenesis Of An Epithelial Tube Growth Hormone Receptor Signaling Pathway
Pathways		Cell surface interactions at the vascular wall	Cell junction organization GAB1 signalosome Smooth Muscle Contraction Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by EGFRvIII in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer VEGFA-VEGFR2 Pathway Signaling by EGFR Signaling by VEGF Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Signaling by EGFR in Cancer Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions
Drugs		O-Sialic Acid
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ACTN2 CD44 FLNA GLG1 LGALS3BP PLCG1 PTK2 PTPN11 PXN SELL SELPLG SERPING1 VCL	73 interactors: ABL1 AHCY AR ARHGEF7 ASAP1 ASAP2 BCAR1 BCL2 CASP3 CEACAM1 CLTC CREB3L2 CRK CRKL CSK DGUOK EPHB1 FYN GART GIT1 GIT2 GRB2 GSK3A GSK3B GSN HDAC6 ILK ITGA4 ITGA6 ITGA9 ITGB1 ITGB3 LCK LIMK1 MAPK1 MAPK3 MAPK8 MATK NCK1 NEDD9 NF2 PABPC1 PAK1 PAK3 PARVA PDPK1 PKD1 POLR1D PPP2CA PPP2R5C PTEN PTK2 PTK2B PTPN11 PTPN12 PTPRH RASA1 REPS2 RNF5 SDC4 SELE SORBS1 SRC SYK TLN1 TRIP6 TUBA1B TUBA3C TUBA8 TUBG1 TUBG2 VCL XPO1
Entrez ID		6401	5829
HPRD ID		00566	03937
Ensembl ID		ENSG00000007908	ENSG00000089159
Uniprot IDs		P16581	E7EMK8 F5GZ78 P49023
PDB IDs		1ESL 1G1T 1KJA	1KKY 1KL0 1OW6 1OW7 1OW8 2K2R 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3C 3U3F 4EDN
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Response To Stress Movement Of Cell Or Subcellular Component Leukocyte Migration Cell Adhesion Platelet Activation Platelet Degranulation Cell Migration Cell Motility Cell Projection Organization Cell Activation Cell Morphogenesis Involved In Differentiation Response To Stimulus Locomotion Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell-matrix Adhesion Adherens Junction Assembly Positive Regulation Of Intracellular Signal Transduction Cell Junction Assembly Vesicle-mediated Transport Cell-substrate Adhesion Immune System Process Regulation Of Protein Metabolic Process Signal Complex Assembly Anatomical Structure Morphogenesis Cellular Response To Growth Factor Stimulus Cell Morphogenesis Response To Growth Factor Adherens Junction Organization Cell Projection Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Exocytosis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Defense Response Integrin-mediated Signaling Pathway Innate Immune Response Protein Localization To Cell Surface Cell Projection Morphogenesis Regulation Of Signaling Cell Part Morphogenesis Positive Regulation Of Phosphorylation Regulation Of Immune Response Positive Regulation Of MAPK Cascade	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Organization Locomotion Movement Of Cell Or Subcellular Component Regulation Of Cell Adhesion Cell Morphogenesis Involved In Differentiation Response To Wounding Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Wound Healing Blood Coagulation Regulation Of Phosphorylation Hemostasis Cell Migration Response To External Stimulus Cell Projection Morphogenesis Axonogenesis Cell Part Morphogenesis Cell Morphogenesis Immune System Process Immune Response-regulating Signaling Pathway Neuron Projection Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Positive Regulation Of Catalytic Activity Axon Development Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Cell Projection Organization Regulation Of Phosphorus Metabolic Process Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Positive Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Chemotaxis Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Kinase Activity Neuron Projection Development Response To Stress Positive Regulation Of Protein Phosphorylation Signal Transduction Cell-substrate Adhesion
Tagcloud ?		2000bp 500bp annotated cor cst11 cyp2b13 cyp2b9 cyp2d9 cyp3a41 cyp3a44 cyp4a10 cyp7b1 ddc defb43 esr2 fmo3 hsd3b5 hypo masculinization masculinize methylatable nimblegen permanently slco1a1 sult2a2 tss ugt2b1 ugt2b38 unmethylated	acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mapk10 mylk oxphos pak3 pathoetiology plcb1 skew sos1 unacclimatized vasoconstriction vcam1
Tagcloud (Difference) ?		2000bp 500bp annotated cor cst11 cyp2b13 cyp2b9 cyp2d9 cyp3a41 cyp3a44 cyp4a10 cyp7b1 ddc defb43 esr2 fmo3 hsd3b5 hypo masculinization masculinize methylatable nimblegen permanently slco1a1 sult2a2 tss ugt2b1 ugt2b38 unmethylated	acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mapk10 mylk oxphos pak3 pathoetiology plcb1 skew sos1 unacclimatized vasoconstriction vcam1
Tagcloud (Intersection) ?