ABCB1 and HAX1

Number of citations of the paper that reports this interaction (PMID 15159385)
11

Data Source:
HPRD (in vivo, two hybrid)

		ABCB1	HAX1
Gene Name		ATP-binding cassette, sub-family B (MDR/TAP), member 1	HCLS1 associated protein X-1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Nuclear Envelope Transcription Factor Complex Mitochondrion Endoplasmic Reticulum Actin Cytoskeleton Apical Plasma Membrane Sarcoplasmic Reticulum Lamellipodium Clathrin-coated Vesicle Nuclear Membrane
	Molecular Function	Transporter Activity Protein Binding ATP Binding Xenobiotic-transporting ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances	Protein Binding Protein Domain Specific Binding Interleukin-1 Binding Protein N-terminus Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Transport Drug Transmembrane Transport Response To Drug Xenobiotic Transport Small Molecule Metabolic Process Transmembrane Transport Stem Cell Proliferation	Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Regulation Of Mitochondrion Degradation Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		ABC-family proteins mediated transport Abacavir transmembrane transport Abacavir transport and metabolism
Drugs		Adenosine triphosphate Roxithromycin Voacamine
Diseases
GWAS
Protein-Protein Interactions		10 interactors: BCCIP CAV1 CD4 HAX1 LNX1 MAPKAP1 MAPRE1 PIM1 PSMB8 RNF2	23 interactors: ABCB1 ABCB11 ABCB4 BIRC3 CTTN DGKD EIF3F HCLS1 HNF4G IL1A KIAA0513 MAPK10 NEDD4L PKD2 POLR1D PPP3CC RBX1 RPA1 STAT5B SVIL YWHAQ ZNF420 ZNRD1
Entrez ID		5243	10456
HPRD ID		01370	12075
Ensembl ID		ENSG00000085563	ENSG00000143575
Uniprot IDs		A4D1D2 P08183	O00165
PDB IDs
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Cell Cycle Positive Regulation Of Cell-cell Adhesion Mitotic Cell Cycle Phase Transition Positive Regulation Of Protein Phosphorylation Cell Cycle Phase Transition Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Phosphorus Metabolic Process Regulation Of T Cell Activation Regulation Of Kinase Activity Positive Regulation Of Cell Activation Positive Regulation Of Phosphorylation Positive Regulation Of Immune System Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Membrane Repolarization During Action Potential Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Induction By Virus Of Host Cell-cell Fusion Protein Palmitoleylation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Lymphocyte Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Ubiquitination Regulation Of Cell Activation Nitric Oxide Homeostasis Histone H2A-K119 Monoubiquitination Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Canonical Wnt Signaling Pathway Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Positive Regulation Of Microtubule Plus-end Binding Regulation Of Inward Rectifier Potassium Channel Activity Positive Regulation Of Signal Transduction Viral Process Positive Regulation Of Transferase Activity Regulation Of Immune System Process	Positive Regulation Of Organelle Organization Positive Regulation Of Interleukin-2 Production Xenobiotic Transport Response To Abiotic Stimulus Positive Regulation Of Transport DNA-templated Transcription, Initiation Regulation Of Protein Localization Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Signal Transduction Positive Regulation Of Cell Cycle Regulation Of Organelle Organization Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Interleukin-2 Biosynthetic Process Regulation Of Apoptotic Process Response To Stimulus Regulation Of Cellular Localization Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Positive Regulation Of Cytokine Production Regulation Of Establishment Of Protein Localization Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Drug Transmembrane Transport Positive Regulation Of Cation Channel Activity Transcription From RNA Polymerase I Promoter Immune System Process Response To Stress Regulation Of Protein Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Transporter Activity Acute-phase Response Regulation Of Intracellular Transport Positive Regulation Of Innate Immune Response Actin Filament Polymerization Protein Monoubiquitination Positive Regulation Of Intracellular Signal Transduction Drug Transport Signal Transduction Negative Regulation Of Ion Transmembrane Transport Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Ion Transmembrane Transporter Activity Metanephric Cortex Development Metanephric Cortical Collecting Duct Development JAK-STAT Cascade
Tagcloud ?		abcg2 arg72pro arg952lys asp1853asn atm atp7b backgroundovarian chances conclusionsthe emphasized facts gstm1 gstp1 gstt1 ile1145 inverted mark mark0 methodsin pgr question resultsten ser406ala ser894ala underscore unfavorable val660leu xenobiotics	1222a abolishing aciduria arg408gly atp2a2 atrophy biochemically caseinolytic cataracts cerebellar clpb congenital deleterious disability encephalopathy exome intellectual kostmann methylglutaconic movement neutropenia nonprogressive overlapping peptidase prenatal sanger scn unrelated zebrafish
Tagcloud (Difference) ?		abcg2 arg72pro arg952lys asp1853asn atm atp7b backgroundovarian chances conclusionsthe emphasized facts gstm1 gstp1 gstt1 ile1145 inverted mark mark0 methodsin pgr question resultsten ser406ala ser894ala underscore unfavorable val660leu xenobiotics	1222a abolishing aciduria arg408gly atp2a2 atrophy biochemically caseinolytic cataracts cerebellar clpb congenital deleterious disability encephalopathy exome intellectual kostmann methylglutaconic movement neutropenia nonprogressive overlapping peptidase prenatal sanger scn unrelated zebrafish
Tagcloud (Intersection) ?