ABCB1 and LNX1

Number of citations of the paper that reports this interaction (PMID 22889411)
1

Data Source:
BioGRID (two hybrid)

		ABCB1	LNX1
Gene Name		ATP-binding cassette, sub-family B (MDR/TAP), member 1	ligand of numb-protein X 1, E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Cytoplasm
	Molecular Function	Transporter Activity Protein Binding ATP Binding Xenobiotic-transporting ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity PDZ Domain Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Transport Drug Transmembrane Transport Response To Drug Xenobiotic Transport Small Molecule Metabolic Process Transmembrane Transport Stem Cell Proliferation	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Homooligomerization
Pathways		ABC-family proteins mediated transport Abacavir transmembrane transport Abacavir transport and metabolism
Drugs		Adenosine triphosphate Roxithromycin Voacamine
Diseases
GWAS			DNA methylation (variation) ( 23725790)
Protein-Protein Interactions		10 interactors: BCCIP CAV1 CD4 HAX1 LNX1 MAPKAP1 MAPRE1 PIM1 PSMB8 RNF2	218 interactors: ABCA1 ABCB1 ABR ACAT2 ACY3 ADRA1D AGTRAP AIDA AIMP2 AKIRIN2 ALDOC ALKBH3 AMMECR1L APIP APOL4 APP ARHGAP6 ARHGEF16 ARVCF ATPAF2 ATRIP AURKC BCR BLVRA BPIFA1 C1QTNF1 CA8 CALCOCO2 CAMK2N2 CATSPERD CCDC101 CCDC102B CCDC114 CCDC85B CDA CDC42EP4 CEP72 CGN CIB3 CIRBP CITED1 CLDN1 CLDN17 CLDN2 CLK2 COIL CPNE2 CTBP1 CTNND2 CTSO CUTC CXADR DAB1 DAPK1 DCTD DCUN1D5 DDX17 DEPTOR DNPEP DOCK9 DPF2 DVL3 EBF4 EHMT2 EIF4H ENOX1 EPHB3 EXOC8 FAM118A FAM124A FAM212B FAM9B FBP1 FBXL12 FHL3 GAS2L2 GDI1 GIPR GJD4 GOLPH3L GPR142 GRB2 GRIN1 HMBOX1 HOMEZ HSBP1 HTR2B HUNK IGSF5 IL3RA ILF3 INSC ISCU JOSD1 KALRN KCNA4 KCTD1 KCTD13 KCTD17 KCTD6 KHDRBS3 KIAA1598 KLHL12 KRT15 KRTAP4-12 KRTAP4-2 KRTAP9-2 KXD1 LCLAT1 LDOC1 LGALS14 LGR6 LNX2 LRRC3B LSM2 MAGEA11 MAGEB18 MAPK9 MEMO1 METTL21A MRFAP1L1 MRPS24 MTMR9 MTUS2 MUSTN1 MVB12B NADK NAGK NCK2 NECAB2 NEK6 NKD2 NME7 NOTCH2NL NRCAM NUDT14 NUMB NUP37 NXT2 ORMDL3 OSBP2 OSGIN1 PAFAH1B3 PAICS PBK PBLD PCBD1 PDZRN3 PDZRN4 PKDREJ PKM PKP4 POMGNT1 PPIA PPID PQBP1 PRR13 PTGIR PTS RABAC1 RAD51D RAD54B RBMX RBMY1A1 RFPL3 ROBO3 ROPN1 RPIA RUFY4 RUVBL2 SAPCD1 SAT1 SCLT1 SDK1 SLC6A15 SLC6A5 SNCB SNRNP25 SNRPF SPHKAP SRSF1 SSNA1 SSTR3 STAC2 STRN STX5 SUV39H1 SUV39H2 TBCEL THAP7 TIFA TMEM14C TNFRSF18 TPM4 TRAF2 TRIM23 TRIM39 TRIM54 TRIP13 TRMT12 TSC2 TSC22D4 TSSK3 TYRO3 UBE2D2 ULK2 VCP VRK2 WAC WNT8A WWP1 ZADH2 ZBTB43 ZBTB8A ZCCHC10 ZFP64 ZNF581 ZNF593
Entrez ID		5243	84708
HPRD ID		01370	17287
Ensembl ID		ENSG00000085563	ENSG00000072201
Uniprot IDs		A4D1D2 P08183	Q8TBB1
PDB IDs			3B76
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Cell Cycle Positive Regulation Of Cell-cell Adhesion Mitotic Cell Cycle Phase Transition Positive Regulation Of Protein Phosphorylation Cell Cycle Phase Transition Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Phosphorus Metabolic Process Regulation Of T Cell Activation Regulation Of Kinase Activity Positive Regulation Of Cell Activation Positive Regulation Of Phosphorylation Positive Regulation Of Immune System Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Membrane Repolarization During Action Potential Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Induction By Virus Of Host Cell-cell Fusion Protein Palmitoleylation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Lymphocyte Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Ubiquitination Regulation Of Cell Activation Nitric Oxide Homeostasis Histone H2A-K119 Monoubiquitination Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Canonical Wnt Signaling Pathway Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Positive Regulation Of Microtubule Plus-end Binding Regulation Of Inward Rectifier Potassium Channel Activity Positive Regulation Of Signal Transduction Viral Process Positive Regulation Of Transferase Activity Regulation Of Immune System Process	Cellular Component Assembly Protein Homooligomerization Protein Oligomerization Protein Complex Assembly Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Process Regulation Of Cellular Component Organization Cellular Aromatic Compound Metabolic Process Regulation Of Rho Protein Signal Transduction Response To Stimulus Developmental Process Cellular Metabolic Process Peptidyl-lysine Dimethylation Heterocycle Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Neutrophil Degranulation Cellular Response To Stimulus Viral Process Programmed Cell Death Nucleobase-containing Compound Metabolic Process Regulation Of RNA Splicing Cellular Nitrogen Compound Metabolic Process Protein Tetramerization Cell Death Apoptotic Process Death Neuron Recognition Cell Communication Signaling Regulation Of Neutrophil Degranulation Negative Regulation Of Neutrophil Activation Viral Release From Host Cell Regulation Of Rho GTPase Activity Cell-cell Junction Organization Protein Autophosphorylation Response To Abiotic Stimulus Organelle Organization Regulation Of Cell Morphogenesis Nitrogen Compound Metabolic Process Axon Midline Choice Point Recognition Positive Regulation Of Rho GTPase Activity Cell Morphogenesis Involved In Differentiation Regulation Of Protein Homodimerization Activity Regulation Of Ras Protein Signal Transduction Protein Heterooligomerization Biosynthetic Process
Tagcloud ?		abcg2 arg72pro arg952lys asp1853asn atm atp7b backgroundovarian chances conclusionsthe emphasized facts gstm1 gstp1 gstt1 ile1145 inverted mark mark0 methodsin pgr question resultsten ser406ala ser894ala underscore unfavorable val660leu xenobiotics
Tagcloud (Difference) ?		abcg2 arg72pro arg952lys asp1853asn atm atp7b backgroundovarian chances conclusionsthe emphasized facts gstm1 gstp1 gstt1 ile1145 inverted mark mark0 methodsin pgr question resultsten ser406ala ser894ala underscore unfavorable val660leu xenobiotics
Tagcloud (Intersection) ?