ABCB1 and MAPRE1

Number of citations of the paper that reports this interaction (PubMedID 24552808)
37

Data Source:
BioGRID (two hybrid)

		ABCB1	MAPRE1
Description		ATP binding cassette subfamily B member 1	microtubule associated protein RP/EB family member 1
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Brush Border Membrane Apical Part Of Cell Extracellular Exosome External Side Of Apical Plasma Membrane	Spindle Pole Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Microtubule Cytoplasmic Microtubule Focal Adhesion Microtubule Cytoskeleton Cortical Microtubule Cytoskeleton Cell Projection Membrane Microtubule Plus-end Ciliary Basal Body Cell Projection Spindle Midzone Mitotic Spindle Pole Mitotic Spindle Astral Microtubule End Mitotic Spindle Microtubule
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ABC-type Xenobiotic Transporter Activity Efflux Transmembrane Transporter Activity ATP Hydrolysis Activity Transmembrane Transporter Activity Ubiquitin Protein Ligase Binding ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity Carboxylic Acid Transmembrane Transporter Activity Phosphatidylcholine Floppase Activity Phosphatidylethanolamine Flippase Activity Ceramide Floppase Activity ATPase-coupled Intramembrane Lipid Transporter Activity Floppase Activity ABC-type Transporter Activity	RNA Binding Protein Binding Microtubule Binding Identical Protein Binding Cadherin Binding Microtubule Plus-end Binding Protein Serine/threonine Kinase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Response To Hypoxia Placenta Development Xenobiotic Metabolic Process Lipid Transport Female Pregnancy Lactation Circadian Rhythm Response To Xenobiotic Stimulus Hormone Transport Response To Mycotoxin Response To Nutrient Levels Response To Estradiol Response To Lipopolysaccharide Response To Progesterone Response To Vitamin A Response To Vitamin D Response To Glucagon Maintenance Of Blood-brain Barrier Cellular Response To Mycotoxin Daunorubicin Transport Phospholipid Translocation Response To Cadmium Ion Terpenoid Transport Intestinal Absorption Transmembrane Transport Establishment Of Blood-brain Barrier Transepithelial Transport Cellular Response To External Biotic Stimulus Cellular Response To Lipopolysaccharide Cellular Response To Antibiotic Cellular Response To Alkaloid Cellular Response To Tumor Necrosis Factor Cellular Response To Estradiol Stimulus Cellular Hyperosmotic Salinity Response Response To Dexamethasone Cellular Response To Dexamethasone Stimulus Stem Cell Proliferation Response To Thyroxine Response To Alcohol Response To Antineoplastic Agent Ceramide Translocation Export Across Plasma Membrane Transport Across Blood-brain Barrier Response To L-glutamate Protein Localization To Bicellular Tight Junction Response To Glycoside Negative Regulation Of Sensory Perception Of Pain Cellular Response To Nonylphenol Positive Regulation Of Establishment Of Sertoli Cell Barrier Regulation Of Intestinal Absorption Carboxylic Acid Transmembrane Transport Cellular Response To Borneol Cellular Response To L-glutamate Response To Codeine Response To Quercetin Response To Cyclosporin A Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Xenobiotic Transport Across Blood-brain Barrier Establishment Of Blood-retinal Barrier Positive Regulation Of Response To Drug Regulation Of Chloride Transport	Establishment Of Mitotic Spindle Orientation Microtubule Bundle Formation Intracellular Protein Localization Cell Migration Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Protein Localization To Microtubule Microtubule Polymerization Spindle Assembly Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Localization To Centrosome Protein Localization To Mitotic Spindle Protein Localization To Astral Microtubule Non-motile Cilium Assembly
Pathways		Abacavir transmembrane transport ABC-family proteins mediated transport Atorvastatin ADME Prednisone ADME	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs		ATP Medroxyprogesterone acetate Verapamil Roxithromycin Fentanyl Voacamine Elacridar Tesmilifene FM-VP4 Zosuquidar Tariquidar Miltefosine Tocofersolan Hycanthone Concanamycin A Dexverapamil Emopamil Lomerizine Tetrandrine Dofequidar Dexniguldipine ONT-093 HM-30181 Desmethylsertraline Reversin 121 Azvudine
Diseases
GWAS		Appendicular lean mass ( 33097823) Bone mineral density (spine) and age at menarche ( 26312577) Cerebral microbleeds ( 32913026) Gallbladder cancer ( 28274756) Liver enzyme levels (alanine transaminase) ( 33972514) Neurological blood protein biomarker levels ( 31320639) Persistent chemotherapy-induced alopecia in breast cancer ( 32756886)	Brain morphology (MOSTest) ( 32665545) Mean platelet volume ( 32888494) Oily fish consumption ( 32066663) Polycystic ovary syndrome ( 30566500) Pork consumption ( 32066663) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		14 interacting genes: BCCIP CAV1 CD4 CD44 FBXO21 HAX1 LNX1 MAPKAP1 MAPRE1 NEDD4 PIM1 PSMB8 RNF2 USP7	50 interacting genes: ABCB1 APC APC2 APP AURKB BCL3 C20orf202 CASK CCSER1 CDC42 CDK5RAP2 CLASP1 CLASP2 COPS5 COPS8 CSN3 CYLD DCTN1 GTSE1 HSPA1A IKBKG KAT2B KAT5 KLHL12 KLHL21 KNSTRN LMO2 LRP1 MACF1 MARCHF7 MEOX2 NAV1 NUPR1 PAX6 PIK3R4 POLE2 PQBP1 PRPF3 PSMA1 SLAIN1 SPDYE2 SPDYE2B SRC SRPK2 STK11 TERF1 TRAF2 TUBA1A TUBB ZNF653
Entrez ID		5243	22919
HPRD ID		01370	04379
Ensembl ID		ENSG00000085563	ENSG00000101367
Uniprot IDs		A4D1D2 P08183	Q15691
PDB IDs		6C0V 6FN1 6FN4 6QEX 7A65 7A69 7A6C 7A6E 7A6F 7O9W 8Y6H 8Y6I 9CR8 9CTC 9CTF 9CTG	1PA7 1TXQ 1UEG 1VKA 1WU9 1YIB 1YIG 2HKQ 2HL3 2HL5 2QJZ 2R8U 3GJO 3MTU 3MUD 3TQ7 4XA1 4XA3 4XA6 5JV3 5JVM 5JVP 5JVR 5JVS 5JVU 5JX1 5WLQ 6PF2 6PFP 6YF5 6YSH
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Response To Nutrient Levels Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Intracellular Signal Transduction Cellular Response To Nutrient Levels Regulation Of Intracellular Signal Transduction Modification-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin Ligase Complex Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Signal Transduction Negative Regulation Of Potassium Ion Transmembrane Transport Proteolysis Involved In Protein Catabolic Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Proteolysis Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Potassium Ion Transport Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Cortex Regulation Of DNA-binding Transcription Factor Activity Mitotic Spindle Pole Establishment Of Mitotic Spindle Orientation Negative Regulation Of Apoptotic Process Negative Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Regulation Of Cellular Localization Inward Rectifier Potassium Channel Inhibitor Activity Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Interleukin-16 Binding Interleukin-16 Receptor Activity Helper T Cell Enhancement Of Adaptive Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Metabolic Process Formation Of Structure Involved In A Symbiotic Process Positive Regulation Of Cardioblast Proliferation Protein Localization To Astral Microtubule Regulation Of Protein Kinase Activity Protein Stabilization Maintenance Of Protein Location In Cell Establishment Of Spindle Localization Macromolecule Metabolic Process Regulation Of Signal Transduction	Regulation Of Microtubule-based Process Cytoskeleton Regulation Of Microtubule Polymerization Or Depolymerization Microtubule Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Microtubule Cytoskeleton Organization Cytoplasmic Microtubule Microtubule Cytoskeleton Organization Regulation Of Cell Cycle Microtubule-based Process Establishment Of Mitotic Spindle Localization Regulation Of Cellular Component Organization Regulation Of Cytoskeleton Organization Cytoplasm Microtubule Cytoskeleton Regulation Of Organelle Organization Establishment Of Organelle Localization Organelle Localization Mitotic Spindle Microtubule Plus-end Positive Regulation Of Cellular Component Organization Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Establishment Of Spindle Localization Kinetochore Spindle Localization Centrosome Positive Regulation Of Supramolecular Fiber Organization Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Microtubule Binding Cellular Component Assembly Regulation Of Microtubule Depolymerization Microtubule Cytoskeleton Organization Involved In Mitosis Cytosol Establishment Of Localization In Cell Establishment Of Spindle Orientation Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Metabolic Process Microtubule Plus-end Binding Spindle Perinuclear Region Of Cytoplasm Protein Kinase Binding Negative Regulation Of Cellular Component Organization Regulation Of Cell Cycle Process Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cytoskeleton Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Macromolecule Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?