ABCB1 and FBXO21

Number of citations of the paper that reports this interaction (PubMedID 26299618)
44

Data Source:
BioGRID (enzymatic study)

		ABCB1	FBXO21
Description		ATP binding cassette subfamily B member 1	F-box protein 21
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Brush Border Membrane Apical Part Of Cell Extracellular Exosome External Side Of Apical Plasma Membrane	Ubiquitin Ligase Complex Cytosol
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ABC-type Xenobiotic Transporter Activity Efflux Transmembrane Transporter Activity ATP Hydrolysis Activity Transmembrane Transporter Activity Ubiquitin Protein Ligase Binding ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity Carboxylic Acid Transmembrane Transporter Activity Phosphatidylcholine Floppase Activity Phosphatidylethanolamine Flippase Activity Ceramide Floppase Activity ATPase-coupled Intramembrane Lipid Transporter Activity Floppase Activity ABC-type Transporter Activity	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Response To Hypoxia Placenta Development Xenobiotic Metabolic Process Lipid Transport Female Pregnancy Lactation Circadian Rhythm Response To Xenobiotic Stimulus Hormone Transport Response To Mycotoxin Response To Nutrient Levels Response To Estradiol Response To Lipopolysaccharide Response To Progesterone Response To Vitamin A Response To Vitamin D Response To Glucagon Maintenance Of Blood-brain Barrier Cellular Response To Mycotoxin Daunorubicin Transport Phospholipid Translocation Response To Cadmium Ion Terpenoid Transport Intestinal Absorption Transmembrane Transport Establishment Of Blood-brain Barrier Transepithelial Transport Cellular Response To External Biotic Stimulus Cellular Response To Lipopolysaccharide Cellular Response To Antibiotic Cellular Response To Alkaloid Cellular Response To Tumor Necrosis Factor Cellular Response To Estradiol Stimulus Cellular Hyperosmotic Salinity Response Response To Dexamethasone Cellular Response To Dexamethasone Stimulus Stem Cell Proliferation Response To Thyroxine Response To Alcohol Response To Antineoplastic Agent Ceramide Translocation Export Across Plasma Membrane Transport Across Blood-brain Barrier Response To L-glutamate Protein Localization To Bicellular Tight Junction Response To Glycoside Negative Regulation Of Sensory Perception Of Pain Cellular Response To Nonylphenol Positive Regulation Of Establishment Of Sertoli Cell Barrier Regulation Of Intestinal Absorption Carboxylic Acid Transmembrane Transport Cellular Response To Borneol Cellular Response To L-glutamate Response To Codeine Response To Quercetin Response To Cyclosporin A Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Xenobiotic Transport Across Blood-brain Barrier Establishment Of Blood-retinal Barrier Positive Regulation Of Response To Drug Regulation Of Chloride Transport	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Cytokine-mediated Signaling Pathway Hematopoietic Stem Cell Differentiation Hematopoietic Stem Cell Homeostasis ERK1 And ERK2 Cascade
Pathways		Abacavir transmembrane transport ABC-family proteins mediated transport Atorvastatin ADME Prednisone ADME	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		ATP Medroxyprogesterone acetate Verapamil Roxithromycin Fentanyl Voacamine Elacridar Tesmilifene FM-VP4 Zosuquidar Tariquidar Miltefosine Tocofersolan Hycanthone Concanamycin A Dexverapamil Emopamil Lomerizine Tetrandrine Dofequidar Dexniguldipine ONT-093 HM-30181 Desmethylsertraline Reversin 121 Azvudine
Diseases
GWAS		Appendicular lean mass ( 33097823) Bone mineral density (spine) and age at menarche ( 26312577) Cerebral microbleeds ( 32913026) Gallbladder cancer ( 28274756) Liver enzyme levels (alanine transaminase) ( 33972514) Neurological blood protein biomarker levels ( 31320639) Persistent chemotherapy-induced alopecia in breast cancer ( 32756886)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Neurociticism ( 29500382)
Interacting Genes		14 interacting genes: BCCIP CAV1 CD4 CD44 FBXO21 HAX1 LNX1 MAPKAP1 MAPRE1 NEDD4 PIM1 PSMB8 RNF2 USP7	4 interacting genes: ABCB1 CNTNAP4 PIK3R1 UBC
Entrez ID		5243	23014
HPRD ID		01370	09948
Ensembl ID		ENSG00000085563	ENSG00000135108
Uniprot IDs		A4D1D2 P08183	O94952 Q4G104 Q8IUQ5
PDB IDs		6C0V 6FN1 6FN4 6QEX 7A65 7A69 7A6C 7A6E 7A6F 7O9W 8Y6H 8Y6I 9CR8 9CTC 9CTF 9CTG
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Response To Nutrient Levels Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Intracellular Signal Transduction Cellular Response To Nutrient Levels Regulation Of Intracellular Signal Transduction Modification-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin Ligase Complex Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Signal Transduction Negative Regulation Of Potassium Ion Transmembrane Transport Proteolysis Involved In Protein Catabolic Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Proteolysis Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Potassium Ion Transport Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Cortex Regulation Of DNA-binding Transcription Factor Activity Mitotic Spindle Pole Establishment Of Mitotic Spindle Orientation Negative Regulation Of Apoptotic Process Negative Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Regulation Of Cellular Localization Inward Rectifier Potassium Channel Inhibitor Activity Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Interleukin-16 Binding Interleukin-16 Receptor Activity Helper T Cell Enhancement Of Adaptive Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Metabolic Process Formation Of Structure Involved In A Symbiotic Process Positive Regulation Of Cardioblast Proliferation Protein Localization To Astral Microtubule Regulation Of Protein Kinase Activity Protein Stabilization Maintenance Of Protein Location In Cell Establishment Of Spindle Localization Macromolecule Metabolic Process Regulation Of Signal Transduction	D-serine Catabolic Process Glycine Oxidase Activity D-amino-acid Dehydrogenase Activity D-alanine Catabolic Process Leukocyte Mediated Cytotoxicity Cellular Response To Nonylphenol Response To Quercetin Cellular Response To Borneol Response To Codeine Daunorubicin Transport Positive Regulation Of Establishment Of Sertoli Cell Barrier D-serine Metabolic Process D-amino Acid Catabolic Process D-amino-acid Oxidase Activity Cellular Response To External Biotic Stimulus Response To Antineoplastic Agent Response To Cyclosporin A Cellular Response To Mycotoxin Positive Regulation Of Response To Drug Leukocyte Mediated Immunity Phosphatidylethanolamine Flippase Activity Response To Flavonoid Ceramide Floppase Activity Ceramide Translocation Negative Regulation Of Sensory Perception Of Pain Kinase Regulator Activity Perinuclear Endoplasmic Reticulum Membrane Regulation Of Grooming Behavior D-amino Acid Metabolic Process Neutrophil-mediated Killing Of Gram-negative Bacterium Mitochondrial Outer Membrane L-proline Catabolic Process Cell Killing Response To Thyroxine Protein Localization To Bicellular Tight Junction Regulation Of Chloride Transport External Side Of Apical Plasma Membrane Hyperosmotic Salinity Response Xenobiotic Transport Across Blood-brain Barrier Cellular Hyperosmotic Salinity Response Floppase Activity Sphingolipid Translocation Response To Mycotoxin Phosphatidylcholine Floppase Activity Carboxylic Acid Transmembrane Transporter Activity Terpenoid Transport Response To L-phenylalanine Derivative Establishment Of Blood-retinal Barrier Insulin Binding 1-phosphatidylinositol-3-kinase Regulator Activity
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