GRM1 and HOMER1

Number of citations of the paper that reports this interaction (PubMedID 9069287)
0

Data Source:
HPRD (in vitro)

		GRM1	HOMER1
Description		glutamate metabotropic receptor 1	homer scaffold protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Postsynaptic Density Membrane Dendrite G Protein-coupled Receptor Dimeric Complex G Protein-coupled Receptor Homodimeric Complex Cell Projection Neuron Projection Dendriole Synapse Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Z Disc Axon Dendrite Cell Projection Neuron Projection Costamere Dendritic Spine Neuron Spine Apical Part Of Cell Synapse Postsynapse Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity G Protein-coupled Receptor Activity Protein Binding Glutamate Receptor Activity G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration	Protein Binding G Protein-coupled Glutamate Receptor Binding Signaling Adaptor Activity Transmembrane Transporter Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Locomotory Behavior Sensory Perception Of Pain Regulation Of Membrane Potential Positive Regulation Of MAPK Cascade Regulation Of Sensory Perception Of Pain Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Cellular Response To Electrical Stimulus L-glutamate Import Across Plasma Membrane Synaptic Signaling Via Neuropeptide Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration	Skeletal Muscle Contraction Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Behavioral Response To Cocaine Skeletal Muscle Fiber Development Protein Tetramerization Response To Calcium Ion Positive Regulation Of Calcium Ion Transport Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Calcium Ion Import Regulation Of Dendritic Spine Maintenance Regulation Of Store-operated Calcium Entry
Pathways		G alpha (q) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Neurexins and neuroligins Neurexins and neuroligins Sensory perception of sweet, bitter, and umami (glutamate) taste	Neurexins and neuroligins Neurexins and neuroligins
Drugs		Glutamic acid (S)-alpha-methyl-4-carboxyphenylglycine
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 26252872) Suicide ( 31476763) Waist circumference ( 29212154)	Bipolar disorder ( 31043756 34002096) Blood and toenail selenium levels ( 25343990) Cryptococcosis in HIV infection ( 33269293) Height ( 18193045) Hepcidin/ferritin ratio ( 27846281) Lateral ventricle temporal horn volume ( 31530798) Major depressive disorder ( 20673876) Metabolite levels ( 23823483) Toenail selenium levels ( 25343990)
Interacting Genes		41 interacting genes: ADORA1 BECN1 CABIN1 CASR CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2B CDKN2C EFNB2 EPB41L2 EPHA2 ERBB2 FGFR4 GAPDH GPRASP1 GRK2 HOMER1 HOMER2 IGF1R ITPR1 KAT2A KDELR2 LATS2 MAP2K5 MYC NF2 OPRM1 OPTN PDGFRA PRKCA RAF1 RASSF1 STK11 TAMALIN TERT TTYH2 TUBB USP7	31 interacting genes: ABI1 ABI3 AGAP2 AIMP1 BRME1 C1orf116 DBNL DNM3 EFNB2 FAM9A FAT1 FCHSD2 GRIA1 GRIK1 GRM1 GRM5 HOMER3 ITPR1 PATJ PIAS2 RAD54L2 RASAL3 RYR1 RYR2 SHANK1 SHANK2 STX12 SYCE2 TANC1 TRPC1 ZMYM5
Entrez ID		2911	9456
HPRD ID		05129	09211
Ensembl ID		ENSG00000152822	ENSG00000152413
Uniprot IDs		Q13255 Q59HC2	Q5U5K4 Q86YM7
PDB IDs		3KS9 4OR2 7DGD 7DGE
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Kinase Activity Protein Kinase Activity Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Regulation Of Cell Cycle Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cell Surface Receptor Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Protein Phosphorylation Regulation Of Protein Localization Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Epithelial Cell Proliferation Phosphorylation Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signal Transduction Intracellular Signaling Cassette Protein Tyrosine Kinase Activity Regulation Of Multicellular Organismal Process Response To Growth Factor Regulation Of Cell Cycle Process Transferase Activity Mitotic Cell Cycle Phase Transition Intracellular Signal Transduction ATP Binding Cell Cycle Phase Transition Regulation Of Apoptotic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Apoptotic Process Protein Serine/threonine Kinase Activity Regulation Of Programmed Cell Death Regulation Of Cell Cycle G1/S Phase Transition Nucleotide Binding Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation	Postsynaptic Density Glutamate Receptor Signaling Pathway Regulation Of Cytosolic Calcium Ion Concentration Cell Junction Organization Glutamatergic Synapse Dendritic Spine Monoatomic Ion Channel Activity Synapse Synapse Organization Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Intracellularly Gated Calcium Channel Activity Schaffer Collateral - CA1 Synapse Ligand-gated Ion Channel Signaling Pathway Intracellular Calcium Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Postsynaptic Density Membrane Dendrite Neuron Projection Calcium Ion Homeostasis Postsynaptic Membrane Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration G Protein-coupled Glutamate Receptor Signaling Pathway Cell-cell Signaling Learning Regulation Of Synaptic Transmission, Glutamatergic G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential Ryanodine-sensitive Calcium-release Channel Activity Signaling Calcium-mediated Signaling Cell Communication Calcium Channel Activity Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Associative Learning Synapse Assembly Regulation Of Postsynaptic Membrane Potential Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Calcium-induced Calcium Release Activity Dendritic Shaft Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Actin-based Cell Projection Regulation Of Sequestering Of Calcium Ion Cell Junction Assembly Glutamate-gated Calcium Ion Channel Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
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