GRM1 and HOMER1

Number of citations of the paper that reports this interaction (PMID 9069287)
135

Data Source:
HPRD (in vitro)

		GRM1	HOMER1
Gene Name		glutamate receptor, metabotropic 1	homer homolog 1 (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Dendrite G-protein Coupled Receptor Dimeric Complex G-protein Coupled Receptor Homodimeric Complex	Z Disc Cell Junction Axon Neuronal Cell Body Costamere Dendritic Shaft Apical Part Of Cell Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density
	Molecular Function	G-protein Coupled Receptor Activity Protein Binding Glutamate Receptor Activity	Type 5 Metabotropic Glutamate Receptor Binding Protein Complex Scaffold G-protein Coupled Glutamate Receptor Binding Signaling Adaptor Activity Identical Protein Binding Ion Channel Binding Protein Heterodimerization Activity Scaffold Protein Binding
	Biological Process	Activation Of MAPKK Activity Activation Of MAPK Activity G-protein Coupled Receptor Signaling Pathway Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Locomotory Behavior Sensory Perception Of Pain Dimeric G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Regulation Of Sensory Perception Of Pain Regulation Of Synaptic Transmission, Glutamatergic Cellular Response To Electrical Stimulus	Skeletal Muscle Contraction Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Circadian Rhythm Positive Regulation Of Signal Transduction Response To Nicotine Protein Localization To Synapse Behavioral Response To Cocaine Skeletal Muscle Fiber Development Chemical Homeostasis Within A Tissue Response To Calcium Ion Positive Regulation Of Calcium Ion Transport Regulation Of Calcium Ion Import Regulation Of Store-operated Calcium Entry Regulation Of Cation Channel Activity
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		L-Glutamic Acid Acamprosate 4-(1-Amino-1-Carboxy-Ethyl)-Benzoic Acid
Diseases
GWAS			Height ( 18193045) Major depressive disorder ( 20673876)
Protein-Protein Interactions		12 interactors: ADORA1 ADRBK1 EFNB2 GAPDH GPRASP1 GRASP HOMER1 HOMER2 ITPR1 OPTN PRKCA TUBB	19 interactors: ABI3 AGAP2 C19orf57 C1orf116 DNM3 EFNB2 FAT1 GRIA1 GRIK1 GRM1 GRM5 HOMER3 ITPR1 RYR1 RYR2 SHANK1 STX12 TANC1 TRPC1
Entrez ID		2911	9456
HPRD ID		05129	09211
Ensembl ID		ENSG00000152822
Uniprot IDs		F8W805 Q13255 Q59HC2	Q5U5K4 Q86YM7
PDB IDs		3KS9
Enriched GO Terms of Interacting Partners?		Defense Response Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Negative Regulation Of Striated Muscle Contraction Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Negative Regulation Of Signaling Positive Regulation Of Lipase Activity Regulation Of Signal Transduction Chemical Homeostasis Within A Tissue Behavioral Response To Cocaine Regulation Of Signaling Innate Immune Response Regulation Of Store-operated Calcium Entry G-protein Coupled Glutamate Receptor Signaling Pathway Negative Regulation Of Muscle Contraction Regulation Of Muscle Contraction Negative Regulation Of Heart Contraction Epidermal Growth Factor Receptor Signaling Pathway Response To Stimulus Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Heart Contraction Cell Death Regulation Of Behavior Cellular Response To Stimulus Death Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of The Force Of Heart Contraction Negative Regulation Of Signal Transduction Signal Transduction Neurotrophin TRK Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Neurotrophin Signaling Pathway Multicellular Organismal Homeostasis Regulation Of Secretion Musculoskeletal Movement Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-threonine Phosphorylation Immune Response Muscle System Process Regulation Of Hormone Secretion Response To Cocaine Cell Surface Receptor Signaling Pathway Cell Communication Homeostatic Process Glutamate Receptor Signaling Pathway	Glutamate Receptor Signaling Pathway Cell-cell Signaling Cytosolic Calcium Ion Homeostasis G-protein Coupled Glutamate Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol Calcium Ion Homeostasis Regulation Of Sequestering Of Calcium Ion Behavior Regulation Of Ion Transport Calcium Ion Transport Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Transport Regulation Of Ion Homeostasis Cellular Metal Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Synaptic Transmission, Glutamatergic Cellular Cation Homeostasis Calcium Ion Transmembrane Transport Cellular Ion Homeostasis Single-organism Behavior Metal Ion Homeostasis Developmental Process Sarcoplasmic Reticulum Calcium Ion Transport Cellular Response To Caffeine Cellular Chemical Homeostasis Learning Or Memory Ion Homeostasis Cognition Synaptic Transmission Regulation Of Synaptic Transmission Calcium Ion Transport Dendritic Spine Organization Cellular Homeostasis Learning Cell Projection Organization Response To Caffeine Multicellular Organismal Development Anatomical Structure Morphogenesis Ion Transmembrane Transport Anatomical Structure Development Chemical Homeostasis Regulation Of Calcium Ion Transport Ionotropic Glutamate Receptor Signaling Pathway Cellular Response To Alkaloid Positive Regulation Of Ion Transport Synaptic Transmission, Glutamatergic Long-term Memory Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Determination Of Affect
Tagcloud ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi	accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 kat2b kat3a kat3b kat5 multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1
Tagcloud (Difference) ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi	accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 kat2b kat3a kat3b kat5 multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1
Tagcloud (Intersection) ?