GRM1 and HOMER2

Number of citations of the paper that reports this interaction (PMID 9808458)
95

Data Source:
HPRD (in vitro)

		GRM1	HOMER2
Gene Name		glutamate receptor, metabotropic 1	homer homolog 2 (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Dendrite G-protein Coupled Receptor Dimeric Complex G-protein Coupled Receptor Homodimeric Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane Cell Junction Dendrite Neuronal Cell Body Apical Part Of Cell Postsynaptic Membrane Neuronal Postsynaptic Density
	Molecular Function	G-protein Coupled Receptor Activity Protein Binding Glutamate Receptor Activity	Actin Binding Protein Domain Specific Binding GKAP/Homer Scaffold Activity G-protein Coupled Glutamate Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Activation Of MAPKK Activity Activation Of MAPK Activity G-protein Coupled Receptor Signaling Pathway Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Locomotory Behavior Sensory Perception Of Pain Dimeric G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Regulation Of Sensory Perception Of Pain Regulation Of Synaptic Transmission, Glutamatergic Cellular Response To Electrical Stimulus	G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Calcium-mediated Signaling Using Intracellular Calcium Source Behavioral Response To Cocaine Chemical Homeostasis Within A Tissue Regulation Of Store-operated Calcium Entry
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		L-Glutamic Acid Acamprosate 4-(1-Amino-1-Carboxy-Ethyl)-Benzoic Acid
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ADORA1 ADRBK1 EFNB2 GAPDH GPRASP1 GRASP HOMER1 HOMER2 ITPR1 OPTN PRKCA TUBB	11 interactors: AGAP2 APP DBN1 GRM1 ITPR1 KPNA2 LZTS2 RNF41 RYR1 UBXN1 VKORC1
Entrez ID		2911	9455
HPRD ID		05129	07269
Ensembl ID		ENSG00000152822	ENSG00000103942
Uniprot IDs		F8W805 Q13255 Q59HC2	Q9NSB8
PDB IDs		3KS9
Enriched GO Terms of Interacting Partners?		Defense Response Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Negative Regulation Of Striated Muscle Contraction Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Negative Regulation Of Signaling Positive Regulation Of Lipase Activity Regulation Of Signal Transduction Chemical Homeostasis Within A Tissue Behavioral Response To Cocaine Regulation Of Signaling Innate Immune Response Regulation Of Store-operated Calcium Entry G-protein Coupled Glutamate Receptor Signaling Pathway Negative Regulation Of Muscle Contraction Regulation Of Muscle Contraction Negative Regulation Of Heart Contraction Epidermal Growth Factor Receptor Signaling Pathway Response To Stimulus Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Heart Contraction Cell Death Regulation Of Behavior Cellular Response To Stimulus Death Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of The Force Of Heart Contraction Negative Regulation Of Signal Transduction Signal Transduction Neurotrophin TRK Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Neurotrophin Signaling Pathway Multicellular Organismal Homeostasis Regulation Of Secretion Musculoskeletal Movement Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-threonine Phosphorylation Immune Response Muscle System Process Regulation Of Hormone Secretion Response To Cocaine Cell Surface Receptor Signaling Pathway Cell Communication Homeostatic Process Glutamate Receptor Signaling Pathway	Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Endoplasmic Reticulum Calcium Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Signaling Regulation Of Sequestering Of Calcium Ion Cytoplasmic Transport Calcium Ion Transport Into Cytosol Cellular Homeostasis Cytosolic Calcium Ion Transport Cellular Localization Intracellular Transport Glutamate Receptor Signaling Pathway Chemical Homeostasis Dimeric G-protein Coupled Receptor Signaling Pathway Regulation Of Signal Transduction Blood Coagulation Hemostasis Cell Communication Synaptic Growth At Neuromuscular Junction Response To Abiotic Stimulus Establishment Of Localization In Cell Cell Surface Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Collateral Sprouting In Absence Of Injury Cell Communication By Chemical Coupling Response To Stimulus Voluntary Musculoskeletal Movement Multicellular Organismal Development Regulation Of Body Fluid Levels Regulation Of Phosphorylation Collateral Sprouting Axon Midline Choice Point Recognition Wound Healing Cellular Response To Stimulus Regulation Of Ion Homeostasis Homeostatic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Vitamin K Metabolic Process Regulation Of Phosphorus Metabolic Process
Tagcloud ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi	accumbens activational addictive arguing aversion behaviorally blunt cci constriction cpa cpp heroin incentive intrathecal limbic mesolimbic mglur5 motivational neuroadaptations psychopharmacology uninjured
Tagcloud (Difference) ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi	accumbens activational addictive arguing aversion behaviorally blunt cci constriction cpa cpp heroin incentive intrathecal limbic mesolimbic mglur5 motivational neuroadaptations psychopharmacology uninjured
Tagcloud (Intersection) ?