GRM1 and ADORA1

Number of citations of the paper that reports this interaction (PubMedID 11278325)
0

Data Source:
HPRD (in vitro)

		GRM1	ADORA1
Description		glutamate metabotropic receptor 1	adenosine A1 receptor
Image
GO Annotations	Cellular Component	Nucleus Plasma Membrane Postsynaptic Density Membrane Dendrite G Protein-coupled Receptor Dimeric Complex G Protein-coupled Receptor Homodimeric Complex Cell Projection Neuron Projection Dendriole Synapse Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Plasma Membrane Cilium Membrane Basolateral Plasma Membrane Dendrite Axolemma Asymmetric Synapse Presynaptic Membrane Neuronal Cell Body Terminal Bouton Dendritic Spine Cell Body Calyx Of Held Synapse Postsynaptic Membrane Presynaptic Active Zone
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity G Protein-coupled Receptor Activity Protein Binding Glutamate Receptor Activity G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration	G Protein-coupled Adenosine Receptor Activity G Protein-coupled Receptor Binding Purine Nucleoside Binding G Protein-coupled Receptor Activity Protein Binding Heat Shock Protein Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Binding Protein-containing Complex Binding Protein Heterodimerization Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Locomotory Behavior Sensory Perception Of Pain Regulation Of Membrane Potential Positive Regulation Of MAPK Cascade Regulation Of Sensory Perception Of Pain Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Cellular Response To Electrical Stimulus L-glutamate Import Across Plasma Membrane Synaptic Signaling Via Neuropeptide Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration	Temperature Homeostasis Response To Hypoxia G Protein-coupled Adenosine Receptor Signaling Pathway Regulation Of Respiratory Gaseous Exchange By Nervous System Process Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Leukocyte Migration Positive Regulation Of Peptide Secretion Positive Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of Glomerular Filtration Protein Targeting To Membrane Phagocytosis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Glutamate Secretion Response To Purine-containing Compound Lipid Catabolic Process Negative Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Nucleoside Transport Negative Regulation Of Neurotrophin Production Positive Regulation Of Dephosphorylation G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Vasodilation Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Apoptotic Process Positive Regulation Of Potassium Ion Transport Positive Regulation Of MAPK Cascade Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Negative Regulation Of Hormone Secretion Negative Regulation Of Inflammatory Response Cognition Leukocyte Migration Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Regulation Of Sensory Perception Of Pain Negative Regulation Of Synaptic Transmission, Glutamatergic Fatty Acid Homeostasis Regulation Of Cardiac Muscle Contraction Excitatory Postsynaptic Potential Long-term Synaptic Depression Mucus Secretion Negative Regulation Of Mucus Secretion Triglyceride Homeostasis Regulation Of Cardiac Muscle Cell Contraction Apoptotic Signaling Pathway Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Long-term Synaptic Depression
Pathways		G alpha (q) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Neurexins and neuroligins Neurexins and neuroligins Sensory perception of sweet, bitter, and umami (glutamate) taste	Adenosine P1 receptors G alpha (i) signalling events
Drugs		Glutamic acid (S)-alpha-methyl-4-carboxyphenylglycine	Tramadol Caffeine Theophylline Lamotrigine Adenosine Dyphylline Pentoxifylline Enprofylline Gabapentin Aminophylline Oxtriphylline Theobromine Defibrotide Tecadenoson Naxifylline Cannabidiol Istradefylline Tonapofylline Rolofylline
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 26252872) Suicide ( 31476763) Waist circumference ( 29212154)	Asthma ( 27182965 30929738 31361310 31619474 31959851 32296059) Asthma (childhood onset) ( 30929738 31036433) Clozapine-induced agranulocytosis ( 25187353) Systolic blood pressure ( 30224653) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		41 interacting genes: ADORA1 BECN1 CABIN1 CASR CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2B CDKN2C EFNB2 EPB41L2 EPHA2 ERBB2 FGFR4 GAPDH GPRASP1 GRK2 HOMER1 HOMER2 IGF1R ITPR1 KAT2A KDELR2 LATS2 MAP2K5 MYC NF2 OPRM1 OPTN PDGFRA PRKCA RAF1 RASSF1 STK11 TAMALIN TERT TTYH2 TUBB USP7	12 interacting genes: ADA ATXN1L DRD1 EPB41L2 GNAI2 GNAO1 GNAS GNAZ GRM1 P2RY1 SNF8 TSHR
Entrez ID		2911	134
HPRD ID		05129	00042
Ensembl ID		ENSG00000152822	ENSG00000163485
Uniprot IDs		Q13255 Q59HC2	B7Z1L9 B7Z379 P30542
PDB IDs		3KS9 4OR2 7DGD 7DGE	5N2S 5UEN 6D9H 7LD3 7LD4
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Kinase Activity Protein Kinase Activity Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Regulation Of Cell Cycle Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cell Surface Receptor Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Protein Phosphorylation Regulation Of Protein Localization Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Epithelial Cell Proliferation Phosphorylation Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signal Transduction Intracellular Signaling Cassette Protein Tyrosine Kinase Activity Regulation Of Multicellular Organismal Process Response To Growth Factor Regulation Of Cell Cycle Process Transferase Activity Mitotic Cell Cycle Phase Transition Intracellular Signal Transduction ATP Binding Cell Cycle Phase Transition Regulation Of Apoptotic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Apoptotic Process Protein Serine/threonine Kinase Activity Regulation Of Programmed Cell Death Regulation Of Cell Cycle G1/S Phase Transition Nucleotide Binding Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation	Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Heterotrimeric G-protein Complex Dendrite G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Secretion Regulation Of Secretion Cell Body G Protein-coupled Dopamine Receptor Signaling Pathway Mu-type Opioid Receptor Binding Plasma Membrane G Protein-coupled Serotonin Receptor Binding Regulation Of Secretion By Cell System Process Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity Negative Regulation Of Secretion By Cell Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transport Regulation Of Biological Quality Modulation Of Chemical Synaptic Transmission Postsynaptic Membrane G Protein-coupled Adenosine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Muscle System Process Regulation Of Hormone Secretion Regulation Of Body Fluid Levels Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway GTPase Activity Cellular Response To Catecholamine Stimulus Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Response To Catecholamine G Protein-coupled Serotonin Receptor Signaling Pathway Adrenergic Receptor Signaling Pathway Purinergic Nucleotide Receptor Signaling Pathway GTP Binding G Protein-coupled Receptor Activity Regulation Of Insulin Secretion Positive Regulation Of MAPK Cascade Regulation Of Exocytosis Locomotory Behavior Negative Regulation Of Synaptic Transmission Regulation Of Peptide Hormone Secretion Muscle Contraction Negative Regulation Of Insulin Secretion Regulation Of Hormone Levels Negative Regulation Of Peptide Secretion
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