GRM1 and KDELR2

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		GRM1	KDELR2
Description		glutamate metabotropic receptor 1	KDEL endoplasmic reticulum protein retention receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Postsynaptic Density Membrane Dendrite G Protein-coupled Receptor Dimeric Complex G Protein-coupled Receptor Homodimeric Complex Cell Projection Neuron Projection Dendriole Synapse Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cis-Golgi Network Membrane Transport Vesicle COPI-coated Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity G Protein-coupled Receptor Activity Protein Binding Glutamate Receptor Activity G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration	KDEL Sequence Binding ER Retention Sequence Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Locomotory Behavior Sensory Perception Of Pain Regulation Of Membrane Potential Positive Regulation Of MAPK Cascade Regulation Of Sensory Perception Of Pain Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Cellular Response To Electrical Stimulus L-glutamate Import Across Plasma Membrane Synaptic Signaling Via Neuropeptide Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration	Protein Retention In ER Lumen Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Vesicle-mediated Transport Maintenance Of Protein Localization In Endoplasmic Reticulum
Pathways		G alpha (q) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Neurexins and neuroligins Neurexins and neuroligins Sensory perception of sweet, bitter, and umami (glutamate) taste	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs		Glutamic acid (S)-alpha-methyl-4-carboxyphenylglycine
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 26252872) Suicide ( 31476763) Waist circumference ( 29212154)	Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Body mass index ( 26426971) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908) Irritable bowel syndrome ( 25248455) Lymphocyte percentage of white cells ( 27863252 32888494) Mean platelet volume ( 27863252 32888494) Monocyte count ( 27863252 29403010 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Red cell distribution width ( 32888494) Ulcerative colitis ( 28067908)
Interacting Genes		41 interacting genes: ADORA1 BECN1 CABIN1 CASR CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2B CDKN2C EFNB2 EPB41L2 EPHA2 ERBB2 FGFR4 GAPDH GPRASP1 GRK2 HOMER1 HOMER2 IGF1R ITPR1 KAT2A KDELR2 LATS2 MAP2K5 MYC NF2 OPRM1 OPTN PDGFRA PRKCA RAF1 RASSF1 STK11 TAMALIN TERT TTYH2 TUBB USP7	22 interacting genes: AKT1 BECN1 CCND2 CD44 CDK4 CDK6 CDKN2B EPHA2 ERBB2 FGFR4 GRM1 IGF1R KAT2A LATS2 MAP2K3 MET MYC NF2 PDGFRA RASSF1 STK11 TTYH2
Entrez ID		2911	11014
HPRD ID		05129	06598
Ensembl ID		ENSG00000152822	ENSG00000136240
Uniprot IDs		Q13255 Q59HC2	P33947
PDB IDs		3KS9 4OR2 7DGD 7DGE
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Kinase Activity Protein Kinase Activity Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Regulation Of Cell Cycle Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cell Surface Receptor Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Protein Phosphorylation Regulation Of Protein Localization Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Epithelial Cell Proliferation Phosphorylation Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signal Transduction Intracellular Signaling Cassette Protein Tyrosine Kinase Activity Regulation Of Multicellular Organismal Process Response To Growth Factor Regulation Of Cell Cycle Process Transferase Activity Mitotic Cell Cycle Phase Transition Intracellular Signal Transduction ATP Binding Cell Cycle Phase Transition Regulation Of Apoptotic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Apoptotic Process Protein Serine/threonine Kinase Activity Regulation Of Programmed Cell Death Regulation Of Cell Cycle G1/S Phase Transition Nucleotide Binding Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation	Protein Kinase Activity Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Signal Transduction Response To Growth Factor Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signaling Transferase Activity Regulation Of Signal Transduction ATP Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Receptor Complex Regulation Of Cell Cycle Process Regulation Of Cellular Component Organization Protein Phosphorylation Regulation Of Catalytic Activity Nucleotide Binding Regulation Of Epithelial Cell Proliferation Phosphorylation Protein Autophosphorylation Positive Regulation Of Cellular Component Organization Peptidyl-tyrosine Phosphorylation Positive Regulation Of Fibroblast Proliferation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Mitotic Cell Cycle Phase Transition Positive Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Process Cell Cycle Phase Transition Positive Regulation Of Catalytic Activity Negative Regulation Of Intracellular Signal Transduction Animal Organ Development Intracellular Signal Transduction Protein Serine Kinase Activity Cyclin D2-CDK4 Complex Regulation Of Programmed Cell Death Regulation Of Fibroblast Proliferation
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