EPB41 and MACROD1

Number of citations of the paper that reports this interaction (PubMedID 16368544)
0

Data Source:
HPRD (two hybrid)

		EPB41	MACROD1
Description		erythrocyte membrane protein band 4.1	mono-ADP ribosylhydrolase 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Nuclear Body Cell Junction Cortical Cytoskeleton Protein-containing Complex Intercellular Bridge Mitotic Spindle	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Actin Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Cytoskeletal Protein Binding Spectrin Binding Phosphoprotein Binding	Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Deacetylase Activity O-acetyl-ADP-ribose Deacetylase Activity ADP-ribosylglutamate Hydrolase Activity
	Biological Process	Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Cell Division Regulation Of Calcium Ion Transport Regulation Of Intestinal Absorption Positive Regulation Of Protein Localization To Cell Cortex	DNA Damage Response Purine Nucleoside Metabolic Process Protein De-ADP-ribosylation Peptidyl-glutamate ADP-deribosylation
Pathways		Neurexins and neuroligins
Drugs
Diseases		Hereditary elliptocytosis (HE)
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) HDL levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Tourette syndrome ( 30818990)	A body shape index ( 34021172) Bipolar disorder ( 31043756) Body mass index ( 25673413) Body mass index and HDL-C (pairwise) ( 33619380) Body mass index and triglycerides (pairwise) ( 33619380) Fasting insulin ( 34059833) Fruit consumption ( 32066663) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 33339817) Hip circumference adjusted for BMI ( 34021172 25673412) Hip index ( 34021172) Immature fraction of reticulocytes ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Serum uric acid levels ( 32514006) Triacylglycerol 56:6 levels ( 31560688) Triglyceride levels ( 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		40 interacting genes: ACTA1 APP BCAM C2CD2L CASK CD44 CLNS1A CPAP CRYAB DLG1 DRD2 DRD3 EGFR EIF3G EPB42 FKBP2 GDI1 GYPC KPNA2 MACROD1 MYL1 NPPA NUMA1 PRKCB RNF10 RWDD2B SEC14L1 SLC4A1 SMAD3 SPTAN1 SPTB SPTBN1 TJP2 TPM1 TUBA4A U2AF1 U2AF2 YWHAB YWHAQ ZCCHC10	4 interacting genes: EPB41 IKBKG KPNA1 UXT
Entrez ID		2035	28992
HPRD ID		00558	17448
Ensembl ID		ENSG00000159023	ENSG00000133315
Uniprot IDs		A0A2R8Y5G2 A0A2R8Y5Z6 A0A2R8Y6D0 A0A2R8Y7Y3 A0A2R8YD30 A0A2U3TZH6 A0A994J847 P11171 Q1WWM3 Q29RX4 Q59F12	A0A6Q8PH91 Q9BQ69
PDB IDs		1GG3 2RQ1 3QIJ	2X47 6LH4
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Cytoskeleton Spectrin Regulation Of Protein Localization Regulation Of Supramolecular Fiber Organization Cortical Cytoskeleton Protein-containing Complex GMP Kinase Activity Muscle System Process Astral Microtubule Organization GDP Metabolic Process Regulation Of Cellular Localization Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Localization Cell Junction Negative Regulation Of Cytosolic Calcium Ion Concentration Muscle Contraction Ankyrin Binding Regulation Of Neurotransmitter Uptake Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Intracellular Signaling Cassette Cytoskeletal Protein Binding Regulation Of Cytoskeleton Organization Regulation Of Biological Quality Positive Regulation Of Protein Localization To Cell Periphery Regulation Of Actin Filament Organization Regulation Of Transport GMP Metabolic Process Regulation Of Monoatomic Ion Transport Positive Regulation Of Supramolecular Fiber Organization Regulation Of Potassium Ion Transport Cytosol Dopamine Neurotransmitter Receptor Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Protein Transport Actin Filament Capping Regulation Of Cellular Component Organization Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Pre-mRNA 3'-splice Site Binding U2AF Complex System Process Cadherin Binding Positive Regulation Of Transport Actin Filament Binding Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Cell Cycle Ankyrin-1 Complex Extracellular Exosome Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Localization	Mitotic Spindle Protein-containing Complex Satellite Cell Activation Involved In Skeletal Muscle Regeneration Spindle Pole Linear Polyubiquitin Binding Positive Regulation Of Protein Localization To Cell Cortex Postsynapse To Nucleus Signaling Pathway Skeletal Muscle Satellite Cell Proliferation Skeletal Muscle Satellite Cell Activation Establishment Of Organelle Localization Regulation Of Protein Localization To Cell Cortex Spectrin-associated Cytoskeleton Skeletal Muscle Cell Proliferation Establishment Of Localization In Cell NLS-dependent Protein Nuclear Import Complex RPAP3/R2TP/prefoldin-like Complex Transferrin Receptor Binding Anoikis IkappaB Kinase Complex Regulation Of Intestinal Absorption 1-phosphatidylinositol Binding
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