EPB41 and MYL1

Number of citations of the paper that reports this interaction (PubMedID 11071908)
50

Data Source:
HPRD (in vitro)

		EPB41	MYL1
Description		erythrocyte membrane protein band 4.1	myosin light chain 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Nuclear Body Cell Junction Cortical Cytoskeleton Protein-containing Complex Intercellular Bridge Mitotic Spindle	Cytosol Muscle Myosin Complex Myosin Complex Myosin II Complex Myofibril Sarcomere Contractile Muscle Fiber
	Molecular Function	Actin Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Cytoskeletal Protein Binding Spectrin Binding Phosphoprotein Binding	Calcium Ion Binding Structural Constituent Of Muscle
	Biological Process	Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Cell Division Regulation Of Calcium Ion Transport Regulation Of Intestinal Absorption Positive Regulation Of Protein Localization To Cell Cortex	Muscle Contraction Muscle Filament Sliding
Pathways		Neurexins and neuroligins	Striated Muscle Contraction
Drugs
Diseases		Hereditary elliptocytosis (HE)
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) HDL levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Tourette syndrome ( 30818990)	Serum metabolite levels ( 23093944)
Interacting Genes		40 interacting genes: ACTA1 APP BCAM C2CD2L CASK CD44 CLNS1A CPAP CRYAB DLG1 DRD2 DRD3 EGFR EIF3G EPB42 FKBP2 GDI1 GYPC KPNA2 MACROD1 MYL1 NPPA NUMA1 PRKCB RNF10 RWDD2B SEC14L1 SLC4A1 SMAD3 SPTAN1 SPTB SPTBN1 TJP2 TPM1 TUBA4A U2AF1 U2AF2 YWHAB YWHAQ ZCCHC10	7 interacting genes: ACTA1 ACTA2 ANKRD1 APP EPB41 IQGAP1 UBC
Entrez ID		2035	4632
HPRD ID		00558	01180
Ensembl ID		ENSG00000159023	ENSG00000168530
Uniprot IDs		A0A2R8Y5G2 A0A2R8Y5Z6 A0A2R8Y6D0 A0A2R8Y7Y3 A0A2R8YD30 A0A2U3TZH6 A0A994J847 P11171 Q1WWM3 Q29RX4 Q59F12	P05976
PDB IDs		1GG3 2RQ1 3QIJ
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Cytoskeleton Spectrin Regulation Of Protein Localization Regulation Of Supramolecular Fiber Organization Cortical Cytoskeleton Protein-containing Complex GMP Kinase Activity Muscle System Process Astral Microtubule Organization GDP Metabolic Process Regulation Of Cellular Localization Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Localization Cell Junction Negative Regulation Of Cytosolic Calcium Ion Concentration Muscle Contraction Ankyrin Binding Regulation Of Neurotransmitter Uptake Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Intracellular Signaling Cassette Cytoskeletal Protein Binding Regulation Of Cytoskeleton Organization Regulation Of Biological Quality Positive Regulation Of Protein Localization To Cell Periphery Regulation Of Actin Filament Organization Regulation Of Transport GMP Metabolic Process Regulation Of Monoatomic Ion Transport Positive Regulation Of Supramolecular Fiber Organization Regulation Of Potassium Ion Transport Cytosol Dopamine Neurotransmitter Receptor Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Protein Transport Actin Filament Capping Regulation Of Cellular Component Organization Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Pre-mRNA 3'-splice Site Binding U2AF Complex System Process Cadherin Binding Positive Regulation Of Transport Actin Filament Binding Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Cell Cycle Ankyrin-1 Complex Extracellular Exosome Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Localization	Cellular Response To Growth Factor Stimulus Response To Growth Factor Mesenchyme Migration Cell Body Actomyosin Structure Organization Positive Regulation Of MAPK Cascade Supramolecular Fiber Organization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cytosol Regulation Of MAPK Cascade Muscle System Process Actin Cytoskeleton Regulation Of ERK1 And ERK2 Cascade Protein-containing Complex Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Cell Development Cellular Developmental Process Positive Regulation Of Signal Transduction Positive Regulation Of Hepatic Stellate Cell Contraction Response To Transforming Growth Factor Beta Cellular Response To Transforming Growth Factor Beta Stimulus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Actin Cytoskeleton Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Developmental Growth Filopodium Actin Filament Stress Fiber Response To Interleukin-1 Actin Filament-based Process Cytoplasm Structural Constituent Of Cytoskeleton Positive Regulation Of Hepatic Stellate Cell Migration Regulation Of Intracellular Signal Transduction Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Protein Localization Skeletal Myofibril Assembly Extracellular Exosome Juxtaglomerular Apparatus Development PTB Domain Binding
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