EPB41 and NPPA

Number of citations of the paper that reports this interaction (PMID 12542678)
29

Data Source:
BioGRID (pull down)

		EPB41	NPPA
Gene Name		erythrocyte membrane protein band 4.1	natriuretic peptide A
Image
Gene Ontology Annotations	Cellular Component	Nucleus Golgi Apparatus Plasma Membrane Spectrin Spectrin-associated Cytoskeleton Extrinsic Component Of Membrane Cortical Cytoskeleton Intracellular Membrane-bounded Organelle Protein Complex	Extracellular Region Extracellular Space Nucleus Mast Cell Granule Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Spectrin Binding	Receptor Binding Neuropeptide Hormone Activity Peptide Hormone Receptor Binding Neuropeptide Receptor Binding
	Biological Process	Blood Circulation Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Positive Regulation Of Protein Binding	Response To Hypoxia Negative Regulation Of Systemic Arterial Blood Pressure CGMP Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Regulation Of Blood Pressure Positive Regulation Of Heart Rate Gene Expression Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Cell Growth Response To Insulin Response To Muscle Stretch Regulation Of Blood Vessel Size Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cardiac Muscle Contraction Cellular Response To Mechanical Stimulus Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Generation Of L-type Calcium Current
Pathways			Amyloids Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS			Atrial fibrillation ( 19597492) Systolic blood pressure ( 19430483)
Protein-Protein Interactions		39 interactors: ACTA1 APP BCAM C2CD2L CASK CD44 CENPJ CLNS1A CRYAB DLG1 DRD2 DRD3 EGFR EIF3G EPB42 FKBP2 GDI1 GYPC KPNA2 MACROD1 MYL1 NPPA NUMA1 PRKCB RWDD2B SEC14L1 SLC4A1 SMAD3 SPTAN1 SPTB SPTBN1 TJP2 TPM1 TUBA4A U2AF1 U2AF2 YWHAB YWHAQ ZCCHC10	12 interactors: EPB41 ESR1 HNF4A MAGEA12 MME NPR1 NPR2 NPR3 NR5A2 RORB UBQLN1 UBQLN4
Entrez ID		2035	4878
HPRD ID		00558	00164
Ensembl ID		ENSG00000159023	ENSG00000175206
Uniprot IDs		E9PEW9 P11171 Q1WWM3 Q29RX4 Q59F12	P01160
PDB IDs		1GG3 2RQ1 3QIJ	1ANP 1YK0 3N57
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Positive Regulation Of Transport Muscle System Process Cell Development Regulation Of Establishment Of Protein Localization Regulation Of Organelle Organization Muscle Contraction Axonogenesis Movement Of Cell Or Subcellular Component Axon Guidance Axon Development System Development Regulation Of Protein Localization Cellular Component Assembly Regulation Of Cellular Localization Cell Morphogenesis Involved In Neuron Differentiation Cell Differentiation Neuron Projection Morphogenesis Anatomical Structure Development Anatomical Structure Morphogenesis Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Response To External Stimulus Cell Morphogenesis Involved In Differentiation Apoptotic Process Regulation Of Systemic Arterial Blood Pressure Regulation Of Actin Cytoskeleton Organization Programmed Cell Death Multicellular Organismal Development Muscle Filament Sliding Actin-myosin Filament Sliding Ion Homeostasis Negative Regulation Of Protein Kinase B Signaling Cell Death Death Cell Morphogenesis Neuron Projection Development Negative Regulation Of Transport Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Chemotaxis Cell Projection Morphogenesis Regulation Of Dopamine Receptor Signaling Pathway Developmental Process Regulation Of Protein Kinase B Signaling Regulation Of Protein Transport Cell Part Morphogenesis Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Cell Projection Organization	Steroid Hormone Mediated Signaling Pathway Blood Circulation Hormone-mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Regulation Of Blood Pressure Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Receptor Guanylyl Cyclase Signaling Pathway Positive Regulation Of Urine Volume Cellular Response To Organic Cyclic Compound CGMP Biosynthetic Process Positive Regulation Of Nitric-oxide Synthase Activity Cellular Response To Lipid Positive Regulation Of Monooxygenase Activity Response To Steroid Hormone CGMP Metabolic Process Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Oxidoreductase Activity Cyclic Purine Nucleotide Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Cyclic Nucleotide Biosynthetic Process Endocrine Pancreas Development Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cell Proliferation Response To Lipid Cyclic Nucleotide Metabolic Process Regulation Of Oxidoreductase Activity Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Response To Organic Cyclic Compound Response To Organic Substance Cellular Response To Stimulus Response To Hormone Pancreas Development Renal System Process Regulation Of Smooth Muscle Cell Proliferation Body Fluid Secretion Lipid Homeostasis Cellular Response To UV-A Negative Regulation Of Oocyte Maturation Prostate Epithelial Cord Elongation System Development Organ Development Positive Regulation Of Cholesterol Homeostasis Regulation Of Metabolic Process Negative Regulation Of Oocyte Development Regulation Of Growth Hormone Receptor Signaling Pathway
Tagcloud ?		ank1 antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes spta1 sptb ugt1a1	biventricle bv cardiomyogenic circuits combinatorial coordinately cpcs dimethylation dissect h3k27 h3k4 hampered hand1 hey hlhs hypoplastic ips maldevelopment malformations nkx2 notch1 pluripotency pluripotent reconstitute reprogrammed signatures sre tbx2 tnnt2
Tagcloud (Difference) ?		ank1 antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes spta1 sptb ugt1a1	biventricle bv cardiomyogenic circuits combinatorial coordinately cpcs dimethylation dissect h3k27 h3k4 hampered hand1 hey hlhs hypoplastic ips maldevelopment malformations nkx2 notch1 pluripotency pluripotent reconstitute reprogrammed signatures sre tbx2 tnnt2
Tagcloud (Intersection) ?