EPB41 and NPPA

Number of citations of the paper that reports this interaction (PubMedID 12542678)
0

Data Source:
BioGRID (pull down)

		EPB41	NPPA
Description		erythrocyte membrane protein band 4.1	natriuretic peptide A
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Nuclear Body Cell Junction Cortical Cytoskeleton Protein-containing Complex Intercellular Bridge Mitotic Spindle	Extracellular Region Extracellular Space Cytoplasm Brush Border Protein-containing Complex Mast Cell Granule Cell Projection Perikaryon Perinuclear Region Of Cytoplasm Glycinergic Synapse
	Molecular Function	Actin Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Cytoskeletal Protein Binding Spectrin Binding Phosphoprotein Binding	Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Guanylate Cyclase Activator Activity Hormone Receptor Binding Neuropeptide Receptor Binding
	Biological Process	Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Cell Division Regulation Of Calcium Ion Transport Regulation Of Intestinal Absorption Positive Regulation Of Protein Localization To Cell Cortex	Response To Hypoxia System Process Negative Regulation Of Systemic Arterial Blood Pressure Cardiac Conduction System Development Aortic Valve Morphogenesis CGMP Biosynthetic Process Protein Folding Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Regulation Of Blood Pressure Positive Regulation Of Heart Rate Positive Regulation Of CGMP-mediated Signaling Cardiac Muscle Hypertrophy In Response To Stress CGMP-mediated Signaling Negative Regulation Of Cell Growth Response To Insulin Response To Muscle Stretch Sodium Ion Export Across Plasma Membrane Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vasodilation Regulation Of Vascular Permeability Negative Regulation Of JUN Kinase Activity Negative Regulation Of Blood Pressure Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cardiac Muscle Contraction Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Hydrogen Peroxide Cellular Response To Mechanical Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Blood Vessel Diameter Maintenance Synaptic Signaling Via Neuropeptide Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Collecting Lymphatic Vessel Constriction Cellular Response To Angiotensin Response To 3-methylcholanthrene
Pathways		Neurexins and neuroligins	YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Amyloid fiber formation
Drugs
Diseases		Hereditary elliptocytosis (HE)	Atrial fibrillation
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) HDL levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Tourette syndrome ( 30818990)	Atrial fibrillation ( 19597492) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Midregional pro atrial natriuretic peptide levels ( 29237677) Psoriasis ( 25854761) Pulse pressure ( 30578418) Systolic blood pressure ( 19430483 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)
Interacting Genes		40 interacting genes: ACTA1 APP BCAM C2CD2L CASK CD44 CLNS1A CPAP CRYAB DLG1 DRD2 DRD3 EGFR EIF3G EPB42 FKBP2 GDI1 GYPC KPNA2 MACROD1 MYL1 NPPA NUMA1 PRKCB RNF10 RWDD2B SEC14L1 SLC4A1 SMAD3 SPTAN1 SPTB SPTBN1 TJP2 TPM1 TUBA4A U2AF1 U2AF2 YWHAB YWHAQ ZCCHC10	14 interacting genes: EPB41 ESR1 HNF4A HSF2BP MAGEA12 MME NPR1 NPR2 NPR3 NR5A2 RORB UBQLN1 UBQLN2 UBQLN4
Entrez ID		2035	4878
HPRD ID		00558	00164
Ensembl ID		ENSG00000159023	ENSG00000175206
Uniprot IDs		A0A2R8Y5G2 A0A2R8Y5Z6 A0A2R8Y6D0 A0A2R8Y7Y3 A0A2R8YD30 A0A2U3TZH6 A0A994J847 P11171 Q1WWM3 Q29RX4 Q59F12	P01160
PDB IDs		1GG3 2RQ1 3QIJ	1ANP 1YK0 3N57 7BRH 7BRJ 7BRK 8TG9 9BCQ
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Cytoskeleton Spectrin Regulation Of Protein Localization Regulation Of Supramolecular Fiber Organization Cortical Cytoskeleton Protein-containing Complex GMP Kinase Activity Muscle System Process Astral Microtubule Organization GDP Metabolic Process Regulation Of Cellular Localization Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Localization Cell Junction Negative Regulation Of Cytosolic Calcium Ion Concentration Muscle Contraction Ankyrin Binding Regulation Of Neurotransmitter Uptake Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Intracellular Signaling Cassette Cytoskeletal Protein Binding Regulation Of Cytoskeleton Organization Regulation Of Biological Quality Positive Regulation Of Protein Localization To Cell Periphery Regulation Of Actin Filament Organization Regulation Of Transport GMP Metabolic Process Regulation Of Monoatomic Ion Transport Positive Regulation Of Supramolecular Fiber Organization Regulation Of Potassium Ion Transport Cytosol Dopamine Neurotransmitter Receptor Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Protein Transport Actin Filament Capping Regulation Of Cellular Component Organization Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Pre-mRNA 3'-splice Site Binding U2AF Complex System Process Cadherin Binding Positive Regulation Of Transport Actin Filament Binding Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Cell Cycle Ankyrin-1 Complex Extracellular Exosome Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Localization	Natriuretic Peptide Receptor Activity Nuclear Receptor Activity CGMP Biosynthetic Process Hormone Binding CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Peptide Hormone Binding Polyubiquitin Modification-dependent Protein Binding Cyclic Purine Nucleotide Metabolic Process Guanylate Cyclase Activity Intracellular Receptor Signaling Pathway Positive Regulation Of Urine Volume Receptor Guanylyl Cyclase Signaling Pathway Autophagosome Rhythmic Process Nucleobase-containing Compound Biosynthetic Process Female Genitalia Development Positive Regulation Of ERAD Pathway Phosphorus-oxygen Lyase Activity Regulation Of Urine Volume Purine Ribonucleotide Biosynthetic Process Regulation Of ERAD Pathway Peptide Binding Ribose Phosphate Biosynthetic Process Protein-containing Complex Ovulation Cycle Process Sequence-specific DNA Binding Transcription Coregulator Binding Genitalia Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Blood Pressure Purine Nucleotide Biosynthetic Process Blood Circulation G Protein-coupled Peptide Receptor Activity Vacuole Organization Blood Vessel Remodeling Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Macroautophagy Nucleotide Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Developmental Process Involved In Reproduction Organ Growth Zygotic Genome Activation Regulation Of Ornithine Metabolic Process Neuropeptide Processing ANPR-A Receptor Complex Vestibulocochlear Nerve Maturation Negative Regulation Of Store-operated Calcium Channel Activity Purine-containing Compound Biosynthetic Process Regulation Of Hormone Levels
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