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PRDX6 and UCHL5
Number of citations of the paper that reports this interaction (PMID
21800051
)
0
Data Source:
BioGRID
(pull down)
PRDX6
UCHL5
Gene Name
peroxiredoxin 6
ubiquitin carboxyl-terminal hydrolase L5
Image
Gene Ontology Annotations
Cellular Component
Extracellular Space
Cytoplasm
Lysosome
Cytosol
Membrane
Cytoplasmic Membrane-bounded Vesicle
Extracellular Vesicular Exosome
Proteasome Complex
Nucleus
Cytosol
Ino80 Complex
Molecular Function
Glutathione Peroxidase Activity
Phospholipase A2 Activity
Protein Binding
Antioxidant Activity
Peroxiredoxin Activity
Ubiquitin-specific Protease Activity
Endopeptidase Inhibitor Activity
Protein Binding
Omega Peptidase Activity
Poly(A) RNA Binding
Proteasome Binding
Biological Process
Response To Reactive Oxygen Species
Response To Oxidative Stress
Phospholipid Catabolic Process
Hydrogen Peroxide Catabolic Process
Oxidation-reduction Process
DNA Repair
DNA Recombination
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Ubiquitin-dependent Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Endopeptidase Activity
Protein Deubiquitination
Lateral Ventricle Development
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Midbrain Development
Forebrain Morphogenesis
Regulation Of Proteasomal Protein Catabolic Process
Pathways
Detoxification of Reactive Oxygen Species
Loss of Function of TGFBR2 in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
Downregulation of TGF-beta receptor signaling
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGF-beta receptor signaling activates SMADs
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Cannabis dependence (
21668797
)
Protein-Protein Interactions
14 interactors:
CASP10
CASP8
GPX4
HNF4G
NCF2
NR4A1
ORM2
PAXIP1
PPARD
RARA
SUMO4
TERF1
TERF2IP
UCHL5
96 interactors:
ACTN4
ADRM1
ANP32B
ANP32E
ANXA1
ANXA4
ANXA7
ANXA8
APP
ARG1
ASPRV1
CALM1
CAP1
CAPZA1
CASP14
CDSN
CFL1
CSTA
DSC1
DSC3
DSP
DUSP14
EEF1G
EEF2
EIF4A1
EPPK1
FLG
GSTM3
HAUS7
HBA1
HBA2
HBB
HIST1H4A
HIST1H4B
HIST1H4C
HIST1H4D
HIST1H4E
HIST1H4F
HIST1H4H
HIST1H4I
HIST1H4J
HIST1H4K
HIST1H4L
HIST2H4A
HIST2H4B
HIST4H4
HSPB1
IDE
IGHG1
IVL
KDM1A
KRT12
KRT19
KRT26
KRT28
KRT73
KRT78
KRT80
LMNA
NACA
NFRKB
PJA1
PKM
PKP1
PLA2G2A
PNP
POF1B
PRDX6
PSMD8
RAB7A
RBCK1
RFFL
S100A14
S100A16
S100A7
SERPINB12
SERPINB3
SERPINB5
SET
SMAD2
SMAD3
SMAD7
TGM3
TPI1
TRIM27
TRIM46
TRIM54
TRIM55
TRIM63
TUBA4A
TXN
TXN2
UBE3A
USP28
YWHAZ
ZBED1
Entrez ID
9588
51377
HPRD ID
03817
10293
Ensembl ID
ENSG00000117592
ENSG00000116750
Uniprot IDs
P30041
Q9Y5K5
PDB IDs
1PRX
3A7S
3IHR
3RII
3RIS
3TB3
Enriched GO Terms of Interacting Partners
?
Response To Steroid Hormone
Intracellular Receptor Signaling Pathway
Response To Lipid
Response To Organic Cyclic Compound
Steroid Hormone Mediated Signaling Pathway
Response To Hormone
Hormone-mediated Signaling Pathway
Cellular Response To Organic Cyclic Compound
Response To Stress
Transcription Initiation From RNA Polymerase II Promoter
Cellular Response To Steroid Hormone Stimulus
Regulation Of Apoptotic Process
DNA-templated Transcription, Initiation
Response To Stimulus
Regulation Of Cell Death
Cellular Response To Hormone Stimulus
Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance
Epithelial Cell Migration
Response To Organic Substance
Epithelium Migration
Cellular Response To Organic Substance
Response To Estradiol
Regulation Of Telomere Maintenance
Positive Regulation Of Intracellular Signal Transduction
RNA-dependent DNA Replication
Cellular Response To Lipid
Cardiovascular System Development
Response To Vitamin A
Transcription, DNA-templated
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Ameboidal-type Cell Migration
Telomere Maintenance Via Telomere Lengthening
Developmental Process
RNA Biosynthetic Process
Regulation Of Chromosome Organization
Response To Estrogen
Adipose Tissue Development
Positive Regulation Of Apoptotic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Programmed Cell Death
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Cell Death
Connective Tissue Development
Macromolecule Biosynthetic Process
Response To Activity
Regulation Of Proteolysis
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Signal Transduction
Cellular Nitrogen Compound Metabolic Process
Histone H4-K20 Demethylation
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Hematopoietic Progenitor Cell Differentiation
DNA Replication-dependent Nucleosome Assembly
Regulation Of Megakaryocyte Differentiation
DNA Methylation On Cytosine
Chromatin Silencing At RDNA
Regulation Of Hematopoietic Progenitor Cell Differentiation
Histone Exchange
Histone Lysine Demethylation
Histone Demethylation
Protein Demethylation
CENP-A Containing Nucleosome Assembly
Chromatin Silencing
DNA Replication-independent Nucleosome Assembly
Demethylation
Centromere Complex Assembly
ATP-dependent Chromatin Remodeling
Negative Regulation Of Gene Expression, Epigenetic
Gene Silencing
DNA Methylation
Nucleosome Organization
Nucleosome Assembly
Chromatin Assembly
Telomere Maintenance
Negative Regulation Of Myeloid Cell Differentiation
DNA Modification
Chromatin Assembly Or Disassembly
Protein-DNA Complex Assembly
Protein Complex Assembly
Regulation Of Gene Expression, Epigenetic
DNA Packaging
Cellular Component Assembly
Regulation Of Myeloid Cell Differentiation
DNA Conformation Change
Chromatin Remodeling
Negative Regulation Of Cellular Metabolic Process
Regulation Of Immune System Process
Cellular Macromolecular Complex Assembly
Negative Regulation Of Cell Differentiation
Mitotic Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Immune System Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Histone Modification
Negative Regulation Of Gene Expression
Keratinocyte Differentiation
Cellular Protein Metabolic Process
Homeostatic Process
Tagcloud
?
1g
accompanied
activities
altered
bifunctional
carcinogen
ccl5
ccr5
clear
colocalized
cytokine
definitive
especially
glutathione
gpx
ipla2
jak2
lung
mice
pathophysiological
peroxidase
promotes
stat3
tg
though
transgenic
tumors
urethane
validated
Tagcloud (Difference)
?
1g
accompanied
activities
altered
bifunctional
carcinogen
ccl5
ccr5
clear
colocalized
cytokine
definitive
especially
glutathione
gpx
ipla2
jak2
lung
mice
pathophysiological
peroxidase
promotes
stat3
tg
though
transgenic
tumors
urethane
validated
Tagcloud (Intersection)
?