PRDX6 and NCF2

Number of citations of the paper that reports this interaction (PubMedID 12121978)
0

Data Source:
HPRD (in vivo)

		PRDX6	NCF2
Description		peroxiredoxin 6	neutrophil cytosolic factor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Cytosol Membrane Azurophil Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome	Acrosomal Vesicle Cytoplasm Cytosol Plasma Membrane Membrane Phagolysosome NADPH Oxidase Complex
	Molecular Function	Catalytic Activity Peroxidase Activity Glutathione Peroxidase Activity Phospholipase A2 Activity Protein Binding Antioxidant Activity Oxidoreductase Activity Transferase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Cadherin Binding 1-acylglycerophosphocholine O-acyltransferase Activity Calcium-independent Phospholipase A2 Activity Peroxiredoxin Activity	Protein Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity Small GTPase Binding
	Biological Process	Lipid Metabolic Process Response To Oxidative Stress Lipid Catabolic Process Hydrogen Peroxide Catabolic Process Cell Redox Homeostasis Glycerophospholipid Catabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Cellular Oxidant Detoxification	Superoxide Metabolic Process Phagocytosis Cellular Defense Response Superoxide Anion Generation Innate Immune Response Respiratory Burst
Pathways		Detoxification of Reactive Oxygen Species Neutrophil degranulation	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs		2-(N-morpholino)ethanesulfonic acid Copper	Dextromethorphan
Diseases			Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS		Adult body size ( 32376654) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Blood protein levels ( 30072576) Systemic lupus erythematosus ( 26663301) Systemic sclerosis ( 31672989)	Celiac disease ( 31591516) Celiac disease and Rheumatoid arthritis ( 26546613) Systemic lupus erythematosus ( 19838195 26502338 26606652 27399966 28714469 33272962) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
Interacting Genes		22 interacting genes: CASP10 CASP8 GPX4 GSTP1 HNF4G MAPK1 NCF2 NR4A1 ORM2 PAXIP1 PPARD PSMD8 RARA SEPHS2 SFTPA1 STH SUMO2 SUMO4 TERF1 TERF2IP UCHL5 YWHAE	15 interacting genes: AKT1 CDC42 CYBA CYBB GOLGA2 KIFAP3 NCF1 NCF4 PRDX6 PRKDC RAC1 RAC2 S100A8 S100A9 SYTL1
Entrez ID		9588	4688
HPRD ID		03817	01991
Ensembl ID		ENSG00000117592	ENSG00000116701
Uniprot IDs		P30041 V9HWC7	A0A0S2Z457 A0A8V8TMB9 P19878
PDB IDs		1PRX 5B6M 5B6N	1E96 1HH8 1K4U 1OEY 1WM5 2DMO 8WEJ
Enriched GO Terms of Interacting Partners?		Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Nuclear Receptor Activity Positive Regulation Of Telomere Maintenance Death Effector Domain Binding Response To Stress Intracellular Receptor Signaling Pathway Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Response To Estradiol Ripoptosome Positive Regulation Of Metabolic Process Response To External Biotic Stimulus CD95 Death-inducing Signaling Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Shelterin Complex Positive Regulation Of DNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Lipid Regulation Of Canonical NF-kappaB Signal Transduction Nuclear Telomere Cap Complex Nucleus G-rich Strand Telomeric DNA Binding Connective Tissue Development Telomere Capping Apoptotic Process Response To Vitamin Response To Vitamin A Programmed Cell Death Cell Death Protein Tag Activity Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Chromosome Organization Regulation Of Interleukin-1 Beta Production Telomere Maintenance Positive Regulation Of Execution Phase Of Apoptosis Glutathione Peroxidase Activity Face Development Telomere Maintenance Via Telomerase Regulation Of DNA Metabolic Process Regulation Of Interleukin-1 Production Execution Phase Of Apoptosis RNA-templated DNA Biosynthetic Process Response To Ethanol Ubiquitin-like Protein Ligase Binding Regulation Of RNA Metabolic Process Negative Regulation Of MiRNA Transcription Ubiquitin Protein Ligase Binding	NADPH Oxidase Complex Respiratory Burst Superoxide Anion Generation Superoxide Metabolic Process Reactive Oxygen Species Metabolic Process Regulation Of Respiratory Burst Hydrogen Peroxide Metabolic Process Hydrogen Peroxide Biosynthetic Process Superoxide-generating NAD(P)H Oxidase Activity Leukocyte Aggregation Inflammatory Response Positive Regulation Of Cell Growth Reactive Oxygen Species Biosynthetic Process Calprotectin Complex Neutrophil Aggregation Regulation Of Innate Immune Response Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Growth Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Lamellipodium Organization Cellular Response To L-glutamine Phagolysosome Peptidyl-cysteine S-nitrosylation Regulation Of Lamellipodium Assembly Regulation Of Toll-like Receptor Signaling Pathway Defense Response Erythrocyte Enucleation Toll-like Receptor 4 Binding Positive Regulation Of Cell Projection Organization Innate Immune Response Arachidonate Binding Regulation Of Lamellipodium Organization Defense Response To Fungus G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Leukocyte Cell-cell Adhesion Regulation Of Cell Growth Electron Transfer Activity Regulation Of Immune System Process Autocrine Signaling Response To Fungus Regulation Of Respiratory Burst Involved In Inflammatory Response Membrane Defense Response To Symbiont Superoxide-generating NADPH Oxidase Activator Activity Defense Response To Other Organism Protein Kinase Binding Response To Ketone Positive Regulation Of Defense Response Thioesterase Binding Chronic Inflammatory Response
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?