PRDX6 and GPX4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PRDX6	GPX4
Gene Name		peroxiredoxin 6	glutathione peroxidase 4
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Lysosome Cytosol Membrane Cytoplasmic Membrane-bounded Vesicle Extracellular Vesicular Exosome	Nucleus Mitochondrion Cytosol Extracellular Vesicular Exosome
	Molecular Function	Glutathione Peroxidase Activity Phospholipase A2 Activity Protein Binding Antioxidant Activity Peroxiredoxin Activity	Glutathione Peroxidase Activity Selenium Binding Glutathione Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity
	Biological Process	Response To Reactive Oxygen Species Response To Oxidative Stress Phospholipid Catabolic Process Hydrogen Peroxide Catabolic Process Oxidation-reduction Process	Phospholipid Metabolic Process Glutathione Metabolic Process Response To Oxidative Stress Multicellular Organismal Development Aging Arachidonic Acid Metabolic Process Lipoxygenase Pathway Response To Estradiol Hydrogen Peroxide Catabolic Process Small Molecule Metabolic Process Regulation Of Inflammatory Response Oxidation-reduction Process
Pathways		Detoxification of Reactive Oxygen Species	Arachidonic acid metabolism Synthesis of 5-eicosatetraenoic acids Metabolism of lipids and lipoproteins Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives
Drugs			Glutathione
Diseases
GWAS			Crohn's disease ( 21102463 23128233)
Protein-Protein Interactions		14 interactors: CASP10 CASP8 GPX4 HNF4G NCF2 NR4A1 ORM2 PAXIP1 PPARD RARA SUMO4 TERF1 TERF2IP UCHL5	2 interactors: MAPK13 PRDX6
Entrez ID		9588	2879
HPRD ID		03817	11819
Ensembl ID		ENSG00000117592	ENSG00000167468
Uniprot IDs		P30041	P36969
PDB IDs		1PRX	2GS3 2OBI
Enriched GO Terms of Interacting Partners?		Response To Steroid Hormone Intracellular Receptor Signaling Pathway Response To Lipid Response To Organic Cyclic Compound Steroid Hormone Mediated Signaling Pathway Response To Hormone Hormone-mediated Signaling Pathway Cellular Response To Organic Cyclic Compound Response To Stress Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Regulation Of Apoptotic Process DNA-templated Transcription, Initiation Response To Stimulus Regulation Of Cell Death Cellular Response To Hormone Stimulus Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Epithelial Cell Migration Response To Organic Substance Epithelium Migration Cellular Response To Organic Substance Response To Estradiol Regulation Of Telomere Maintenance Positive Regulation Of Intracellular Signal Transduction RNA-dependent DNA Replication Cellular Response To Lipid Cardiovascular System Development Response To Vitamin A Transcription, DNA-templated Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Ameboidal-type Cell Migration Telomere Maintenance Via Telomere Lengthening Developmental Process RNA Biosynthetic Process Regulation Of Chromosome Organization Response To Estrogen Adipose Tissue Development Positive Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Programmed Cell Death Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cell Death Connective Tissue Development Macromolecule Biosynthetic Process Response To Activity Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Cellular Nitrogen Compound Metabolic Process
Tagcloud ?		1g accompanied activities altered bifunctional carcinogen ccl5 ccr5 clear colocalized cytokine definitive especially glutathione gpx ipla2 jak2 lung mice pathophysiological peroxidase promotes stat3 tg though transgenic tumors urethane validated	biopsies chc cohorts drive eliminates elimination eradication fusogenic glutathione hcv hepatocarcinogenesis hepatocellular infectivity lipoproteins liposome modulating ns5a peroxidase peroxide peroxides phosphatidylinositol regimens replicative returned ros scavenger scavengers tightly virions
Tagcloud (Difference) ?		1g accompanied activities altered bifunctional carcinogen ccl5 ccr5 clear colocalized cytokine definitive especially gpx ipla2 jak2 lung mice pathophysiological promotes stat3 tg though transgenic tumors urethane validated	biopsies chc cohorts drive eliminates elimination eradication fusogenic hcv hepatocarcinogenesis hepatocellular infectivity lipoproteins liposome modulating ns5a peroxide peroxides phosphatidylinositol regimens replicative returned ros scavenger scavengers tightly virions
Tagcloud (Intersection) ?		glutathione peroxidase