RBM39 and SREK1

Number of citations of the paper that reports this interaction (PubMedID 37071682)
87

Data Source:
BioGRID (biochemical, two hybrid, cross-linking study)

		RBM39	SREK1
Description		RNA binding motif protein 39	splicing regulatory glutamic acid and lysine rich protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Microtubule Cytoskeleton Nuclear Speck Protein-containing Complex Centriolar Satellite	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding RS Domain Binding U1 SnRNP Binding	Nucleic Acid Binding RNA Binding Protein Binding
	Biological Process	RNA Processing MRNA Processing RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome	MRNA Processing RNA Splicing
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Systolic blood pressure ( 30224653)
Interacting Genes		56 interacting genes: AK8 APP ARL6IP4 ASH2L BANP CEBPA CHERP CLK2 CSNK2A1 DARS1-AS1 DCAF15 DDX39B DVL3 ESR1 ESR2 FAM200A GOLGA2 HOMEZ INO80B JUN KHDC4 KMT2A KRTAP12-2 MCPH1 MLX MTNR1A NCOA6 NKAP NKAPD1 OGT PGR PHC2 POU6F2 PRPF38A PRPF40A RBBP5 RBM23 RBM25 REL RNF113A RP9P SAP30BP SDCBP SF3B4 SP100 SREK1 SREK1IP1 SRRM4 THAP1 TOE1 TTC14 U2AF2 USP7 WDR5 ZBTB22 ZCCHC10	66 interacting genes: ARL6IP4 CD8A CKAP2 CSNK2A1 DDX17 DDX39B DDX3X DGKA DGKD EFTUD2 ELAVL1 GPRASP2 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPH1 HNRNPK HNRNPU ILF2 MDM2 MRPL37 NAT10 NCL NPM1 PABPC1 PABPC4 PARP1 PCBP3 PIN1 PRPF40A RAB5C RACK1 RBM10 RBM39 RBMX SAFB SF3A3 SF3B3 SFPQ SH3GLB2 SNRPD1 SNRPD3 SRPK1 SRPK2 SRPK3 SRRM4 SRSF1 SRSF10 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SSRP1 SUPT16H TARBP1 THRAP3 TRA2B TXLNA YBX1 ZRANB2
Entrez ID		9584	140890
HPRD ID		09201	18043
Ensembl ID		ENSG00000131051	ENSG00000153914
Uniprot IDs		A0A384NQ03 B4DRA0 Q14498	Q8WXA9
PDB IDs		2JRS 2MHN 4OO6 4OZ0 4OZ1 4YUD 6PAI 6Q0R 6Q0V 6Q0W 6SJ7 6UD7 6UE5 7Q33
Enriched GO Terms of Interacting Partners?		Nucleoplasm RNA Splicing MRNA Processing MRNA Metabolic Process MLL1/2 Complex Regulation Of RNA Metabolic Process Histone Methyltransferase Complex Nucleus RNA Metabolic Process MLL3/4 Complex RNA Processing Nucleic Acid Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression, Epigenetic Nuclear Speck Nucleobase-containing Compound Metabolic Process Nucleic Acid Binding Spliceosomal Complex MLL1 Complex Regulation Of Transcription By RNA Polymerase II Estrogen Response Element Binding Regulation Of Primary Metabolic Process Identical Protein Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Set1C/COMPASS Complex Negative Regulation Of Biosynthetic Process Rhythmic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Initiation-coupled Chromatin Remodeling Regulation Of Gluconeogenesis Negative Regulation Of RNA Metabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Nuclear Steroid Receptor Activity MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nuclear Estrogen Receptor Activity RNA Splicing, Via Transesterification Reactions Regulation Of Metabolic Process RNA Binding Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process	RNA Splicing RNA Binding MRNA Processing MRNA Metabolic Process RNA Processing Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding Regulation Of RNA Splicing RNA Splicing, Via Transesterification Reactions Nucleic Acid Metabolic Process MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Binding Nuclear Speck Negative Regulation Of MRNA Metabolic Process Catalytic Step 2 Spliceosome Spliceosomal Complex Ribonucleoprotein Complex Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Primary Metabolic Process MRNA Stabilization Regulation Of Gene Expression Spliceosomal Complex Assembly Protein-RNA Complex Assembly Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Catabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Alternative MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Pre-mRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process
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