MINPP1 and ACTA1

Number of citations of the paper that reports this interaction (PubMedID 11536049)
0

Data Source:
HPRD (in vitro, in vivo)

		MINPP1	ACTA1
Description		multiple inositol-polyphosphate phosphatase 1	actin alpha 1, skeletal muscle
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Plasma Membrane Membrane Extracellular Exosome	Stress Fiber Extracellular Space Cytoplasm Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle
	Molecular Function	Acid Phosphatase Activity Inositol Hexakisphosphate Phosphatase Activity Protein Binding Inositol Hexakisphosphate 4-phosphatase Activity Inositol Hexakisphosphate 3-phosphatase Activity Inositol Bisphosphate Phosphatase Activity Hydrolase Activity Phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Inositol-1,4,5,6-tetrakisphosphate 6-phosphatase Activity Bisphosphoglycerate 3-phosphatase Activity Inositol Trisphosphate Phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol Phosphate Phosphatase Activity Inositol Pentakisphosphate Phosphatase Activity	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Hydrolase Activity Myosin Binding ADP Binding
	Biological Process	Ossification Intracellular Monoatomic Cation Homeostasis Bone Mineralization Inositol Phosphate Metabolic Process	Muscle Contraction Positive Regulation Of Gene Expression Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Development Mesenchyme Migration
Pathways		Synthesis of IPs in the ER lumen	Striated Muscle Contraction Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs			Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases			Cap myopathy Congenital fiber type disproportion (CFTD) Nemaline myopathy
GWAS		Blood protein levels ( 30072576) Forehead morphology ( 29921221) Longevity ( 20304771) Pursuit maintenance gain ( 29064472)
Interacting Genes		5 interacting genes: ACTA1 OGT SOX4 SRF UBQLN2	115 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 LINC00624 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1
Entrez ID		9562	58
HPRD ID		05652	00030
Ensembl ID		ENSG00000107789	ENSG00000143632
Uniprot IDs		Q9UNW1	P68133
PDB IDs			7RNS 7RNU 7RNV 9DUU 9DUV
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucose Stimulus Cellular Response To Carbohydrate Stimulus Intracellular Glucose Homeostasis Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription By Glucose Response To Glucose Response To Monosaccharide Response To Carbohydrate Carbohydrate Homeostasis Glucose Homeostasis Cell Development Cellular Response To Nutrient Positive Regulation Of Macromolecule Metabolic Process Intracellular Chemical Homeostasis Chromatin DNA Binding Serum Response Element Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Metabolic Process Hematopoietic Progenitor Cell Differentiation Cellular Homeostasis Bronchus Cartilage Development Lung Smooth Muscle Development Negative Regulation Of G Protein-coupled Receptor Internalization Organelle Assembly Response To Nutrient Protein O-acetylglucosaminyltransferase Activity Ascending Aorta Morphogenesis Pro-B Cell Differentiation Chemical Homeostasis Trachea Cartilage Development Cardiac Vascular Smooth Muscle Cell Differentiation Hemopoiesis Negative Regulation Of Clathrin-dependent Endocytosis Cellular Response To Oxygen-containing Compound Mesenchyme Migration Atrial Septum Primum Morphogenesis Positive Regulation Of Proteolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Proteasomal Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Skeletal Muscle Thin Filament Assembly Tangential Migration From The Subventricular Zone To The Olfactory Bulb Non-canonical Inflammasome Complex Assembly Noradrenergic Neuron Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Nutrient Levels Actin Filament Organization Mitral Valve Morphogenesis	Actin Binding Actin Filament Binding Cytoskeleton Actin Cytoskeleton Actin Filament-based Process Cytoplasm Actin Filament Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Actin Cytoskeleton Organization Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytosol Regulation Of Cellular Component Size Regulation Of Protein-containing Complex Assembly Cell Cortex Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Lamellipodium Ruffle Actin Filament Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Cortical Actin Cytoskeleton Positive Regulation Of Cellular Component Biogenesis Actin Polymerization Or Depolymerization Regulation Of Biological Quality Anchoring Junction Organelle Organization Ruffle Membrane Positive Regulation Of Protein-containing Complex Assembly Cell Projection Filopodium Regulation Of Cell Shape Muscle System Process Negative Regulation Of Actin Filament Depolymerization Regulation Of Protein Localization
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