ATG5 and TRIM21

Number of citations of the paper that reports this interaction (PubMedID 37083684)
43

Data Source:
BioGRID (pull down)

		ATG5	TRIM21
Description		autophagy related 5	tripartite motif containing 21
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GO Annotations	Cellular Component	Cytoplasm Autophagosome Cytosol Axoneme Membrane Axon Phagocytic Vesicle Membrane Protein-containing Complex Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Synapse Phagophore Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse Transferase Complex	P-body Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Cytoplasmic Stress Granule SCF Ubiquitin Ligase Complex Cytoplasmic Vesicle Ribonucleoprotein Complex
	Molecular Function	Protein Binding Atg8-family Ligase Activity	DNA Binding Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Autophagosome Assembly Mitophagy Blood Vessel Remodeling Immune System Process Regulation Of Cytokine Production Involved In Immune Response Chromatin Organization Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Cellular Response To Starvation Response To Xenobiotic Stimulus Response To Fungus Response To Iron(II) Ion Positive Regulation Of Autophagy Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Macroautophagy Protein Ubiquitination Antigen Processing And Presentation Of Endogenous Antigen Negative Regulation Of Protein Ubiquitination Negative Regulation Of Type I Interferon Production Piecemeal Microautophagy Of The Nucleus Aggrephagy Negative Stranded Viral RNA Replication Vasodilation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Post-translational Protein Modification Negative Thymic T Cell Selection Innate Immune Response Negative Regulation Of Innate Immune Response Otolith Development Negative Regulation Of Defense Response To Virus Negative Regulation Of Phagocytosis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Establishment Of Localization In Cell Ventricular Cardiac Muscle Cell Development Heart Contraction Chaperone-mediated Autophagy Positive Regulation Of Stress Granule Assembly Mucus Secretion Positive Regulation Of Mucus Secretion Cellular Response To Nitrosative Stress Axonal Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Autophagosome Maturation Regulation Of Cilium Assembly Response To Fluoride Negative Regulation Of Autophagic Cell Death Positive Regulation Of Viral Translation Regulation Of Reactive Oxygen Species Metabolic Process	Autophagosome Assembly Protein Polyubiquitination Protein Monoubiquitination Canonical NF-kappaB Signal Transduction Regulation Of Gene Expression Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Stress Granule Assembly Response To Type II Interferon Stress Granule Disassembly Protein K27-linked Ubiquitination Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Cell Cycle Negative Regulation Of Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Viral Entry Into Host Cell Protein Autoubiquitination Cellular Response To Chemical Stress Pyroptotic Inflammatory Response Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Primary Metabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Protein Deubiquitination Antiviral Innate Immune Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling	STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA Interferon gamma signaling KEAP1-NFE2L2 pathway Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Glucose homeostasis traits ( 25524916) Limited cutaneous systemic scleroderma ( 24387989) Monobrow ( 27182965) Multiple myeloma ( 33875642 27363682) Rheumatoid arthritis ( 24390342 30423114) Systemic lupus erythematosus ( 28714469 19838193 27399966 26502338 23273568) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 31672989 24387989) Visceral fat ( 30942860) Youthful appearance (self-reported) ( 32339537)	Lung cancer ( 28604730) Malaria ( 31844061)
Interacting Genes		31 interacting genes: ATG10 ATG12 ATG16L1 ATG16L2 ATP23 CALCOCO2 CAPN1 CAPN2 CCHCR1 FADD FMR1 GRIPAP1 HOOK2 INCA1 IRGM KEAP1 KIAA1328 MAD1L1 MEOX2 MYC NLRP6 OPTN PSMB11 RACK1 TECPR1 TEKT4 TIAM1 TRIM21 USP13 VCP WDFY3	86 interacting genes: AGO4 AIFM2 ALOX15B APC ATG5 CASP8AP2 CBX4 CDC34 CDKN1A CLSPN CUL1 CWC25 DAXX DCP2 DLGAP1-AS2 DMAP1 DZIP3 EHHADH ELAVL1 EXOC8 FADD FBXW11 FHOD1 G3BP1 GABARAP GABARAPL1 GABARAPL2 GMCL1 GRAP HLA-DRB1 IGFN1 IGHG1 IGHV4-31 IKBKB IRF5 IRF8 LNX1 LPP MAP1LC3A MAP1LC3B MAP1LC3C MNAT1 NAT8 NIF3L1 PFKP PPP1CA RAB11FIP1 RAB11FIP5 RNF111 RO60 SAMHD1 SETD7 SIRT5 SKP2 STK3 TBK1 TCP11L1 TNS4 TP53 TRIM27 TRIM3 TRIM39 TRIM5 TRIM8 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G2 UBE2I UBE2L3 UBE2N UBE2V1 UBE2W USP15 USP2 USP4 VPS9D1 WEE2-AS1 XAF1 YJU2 YWHAZ ZBTB16
Entrez ID		9474	6737
HPRD ID		16051	00170
Ensembl ID		ENSG00000057663	ENSG00000132109
Uniprot IDs		A0A2R8Y718 A9UGY9 Q7Z3H3 Q9H1Y0	P19474
PDB IDs		4GDK 4GDL 4NAW 4TQ0 4TQ1 5D7G 5NPV 5NPW 7W36	2IWG 5JPX 5OLM 6FGA 6S53 7BBD 8A58 8Y58 8Y59 8Y5B 9QBA
Enriched GO Terms of Interacting Partners?		Autophagy Macroautophagy Regulation Of Autophagy Autophagosome Atg12-Atg5-Atg16 Complex Catabolic Process Autophagosome Membrane Regulation Of Autophagosome Maturation Autophagosome Assembly Cytosol Vacuole Organization Positive Regulation Of Catabolic Process Autophagosome Organization Cytoplasm Protein-containing Complex Disassembly Identical Protein Binding Regulation Of Macroautophagy Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Autophagosome Maturation C-terminal Protein Lipidation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Viral Genome Replication Phagophore Assembly Site Membrane Macromolecule Catabolic Process Negative Stranded Viral RNA Replication Signaling Adaptor Activity Protein Transport Positive Regulation Of Autophagy Calpain Complex BAT3 Complex Binding Regulation Of Proteasomal Protein Catabolic Process Organelle Assembly Protein-containing Complex Binding Positive Regulation Of Protein Catabolic Process Negative Regulation Of Immune System Process BH3 Domain Binding Regulation Of Proteolysis Establishment Of Protein Localization Response To Virus Stress Granule Disassembly Xenophagy Positive Regulation Of Autophagosome Maturation Viral RNA Genome Replication Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Xenophagy Post-translational Protein Modification Protein Catabolic Process Positive Regulation Of Cellular Component Organization Protein-containing Complex Organization	Post-translational Protein Modification Protein Polyubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Protein Modification Process Protein Ubiquitination Cellular Response To Nitrogen Starvation Cytosol Ubiquitin Protein Ligase Binding Cellular Response To Nutrient Levels Catabolic Process Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Phosphatidylethanolamine Binding Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Response To Nutrient Levels Mitophagy Response To Stress Cellular Response To Stress Positive Regulation Of Canonical NF-kappaB Signal Transduction Defense Response To Virus Cytoplasm Cellular Response To Starvation Autophagosome Organization Macromolecule Metabolic Process Protein K48-linked Ubiquitination Autophagy Of Mitochondrion Regulation Of Protein Ubiquitination Nucleus Regulation Of Canonical NF-kappaB Signal Transduction Response To Virus Proteolysis Response To Starvation Vacuole Organization Positive Regulation Of Protein Polyubiquitination Autophagosome Assembly TORC1 Signaling Positive Regulation Of Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Defense Response To Other Organism Negative Regulation Of TORC1 Signaling Positive Regulation Of Metabolic Process Transferase Activity Positive Regulation Of Protein Ubiquitination PML Body Protein K63-linked Ubiquitination Macroautophagy
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