ATG5 and ATG16L2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (pull down, affinity chromatography technology)

		ATG5	ATG16L2
Description		autophagy related 5	autophagy related 16 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Autophagosome Cytosol Axoneme Membrane Axon Phagocytic Vesicle Membrane Protein-containing Complex Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Synapse Phagophore Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse Transferase Complex	Nucleoplasm Cytoplasm Autophagosome Cytosol Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex
	Molecular Function	Protein Binding Atg8-family Ligase Activity
	Biological Process	Autophagosome Assembly Mitophagy Blood Vessel Remodeling Immune System Process Regulation Of Cytokine Production Involved In Immune Response Chromatin Organization Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Cellular Response To Starvation Response To Xenobiotic Stimulus Response To Fungus Response To Iron(II) Ion Positive Regulation Of Autophagy Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Macroautophagy Protein Ubiquitination Antigen Processing And Presentation Of Endogenous Antigen Negative Regulation Of Protein Ubiquitination Negative Regulation Of Type I Interferon Production Piecemeal Microautophagy Of The Nucleus Aggrephagy Negative Stranded Viral RNA Replication Vasodilation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Post-translational Protein Modification Negative Thymic T Cell Selection Innate Immune Response Negative Regulation Of Innate Immune Response Otolith Development Negative Regulation Of Defense Response To Virus Negative Regulation Of Phagocytosis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Establishment Of Localization In Cell Ventricular Cardiac Muscle Cell Development Heart Contraction Chaperone-mediated Autophagy Positive Regulation Of Stress Granule Assembly Mucus Secretion Positive Regulation Of Mucus Secretion Cellular Response To Nitrosative Stress Axonal Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Autophagosome Maturation Regulation Of Cilium Assembly Response To Fluoride Negative Regulation Of Autophagic Cell Death Positive Regulation Of Viral Translation Regulation Of Reactive Oxygen Species Metabolic Process	Autophagosome Assembly Autophagy Protein Transport Macroautophagy Negative Stranded Viral RNA Replication
Pathways		Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling	Macroautophagy
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Glucose homeostasis traits ( 25524916) Limited cutaneous systemic scleroderma ( 24387989) Monobrow ( 27182965) Multiple myeloma ( 33875642 27363682) Rheumatoid arthritis ( 24390342 30423114) Systemic lupus erythematosus ( 28714469 19838193 27399966 26502338 23273568) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 31672989 24387989) Visceral fat ( 30942860) Youthful appearance (self-reported) ( 32339537)	Crohn's disease ( 23266558 23850713) Non-albumin protein levels ( 29403010) Systemic lupus erythematosus ( 26663301)
Interacting Genes		31 interacting genes: ATG10 ATG12 ATG16L1 ATG16L2 ATP23 CALCOCO2 CAPN1 CAPN2 CCHCR1 FADD FMR1 GRIPAP1 HOOK2 INCA1 IRGM KEAP1 KIAA1328 MAD1L1 MEOX2 MYC NLRP6 OPTN PSMB11 RACK1 TECPR1 TEKT4 TIAM1 TRIM21 USP13 VCP WDFY3	4 interacting genes: ATG5 RAB33A RAB33B TK1
Entrez ID		9474	89849
HPRD ID		16051	10959
Ensembl ID		ENSG00000057663	ENSG00000168010
Uniprot IDs		A0A2R8Y718 A9UGY9 Q7Z3H3 Q9H1Y0	Q8NAA4
PDB IDs		4GDK 4GDL 4NAW 4TQ0 4TQ1 5D7G 5NPV 5NPW 7W36
Enriched GO Terms of Interacting Partners?		Autophagy Macroautophagy Regulation Of Autophagy Autophagosome Atg12-Atg5-Atg16 Complex Catabolic Process Autophagosome Membrane Regulation Of Autophagosome Maturation Autophagosome Assembly Cytosol Vacuole Organization Positive Regulation Of Catabolic Process Autophagosome Organization Cytoplasm Protein-containing Complex Disassembly Identical Protein Binding Regulation Of Macroautophagy Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Autophagosome Maturation C-terminal Protein Lipidation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Viral Genome Replication Phagophore Assembly Site Membrane Macromolecule Catabolic Process Negative Stranded Viral RNA Replication Signaling Adaptor Activity Protein Transport Positive Regulation Of Autophagy Calpain Complex BAT3 Complex Binding Regulation Of Proteasomal Protein Catabolic Process Organelle Assembly Protein-containing Complex Binding Positive Regulation Of Protein Catabolic Process Negative Regulation Of Immune System Process BH3 Domain Binding Regulation Of Proteolysis Establishment Of Protein Localization Response To Virus Stress Granule Disassembly Xenophagy Positive Regulation Of Autophagosome Maturation Viral RNA Genome Replication Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Xenophagy Post-translational Protein Modification Protein Catabolic Process Positive Regulation Of Cellular Component Organization Protein-containing Complex Organization	Autophagosome Organization Autophagosome Assembly Rab Protein Signal Transduction Vacuole Organization Phagophore Assembly Site Membrane Cellular Component Assembly Thymidine Kinase Activity Organelle Assembly Antigen Processing And Presentation Otolith Development Positive Regulation Of Viral Translation Negative Regulation Of Constitutive Secretory Pathway Regulation Of Retrograde Vesicle-mediated Transport, Golgi To ER DNA Synthesis Involved In Mitotic DNA Replication Negative Regulation Of Autophagic Cell Death Phagophore Atg8-family Ligase Activity Negative Stranded Viral RNA Replication Response To Fluoride Cellular Response To Nitrosative Stress Thymidine Biosynthetic Process Positive Regulation Of Mucus Secretion Thymidine Metabolic Process Small GTPase-mediated Signal Transduction Positive Regulation Of Stress Granule Assembly Chaperone-mediated Autophagy Response To Iron(II) Ion Viral RNA Genome Replication Atg12-Atg5-Atg16 Complex Autophagy Regulation Of Mucus Secretion Response To Nitrosative Stress GTPase Activity Deoxyribonucleoside Monophosphate Biosynthetic Process Ventricular Cardiac Muscle Cell Development Cellular Response To Nitrogen Starvation GTP Binding Regulation Of Stress Granule Assembly Pyrimidine Nucleoside Metabolic Process Cardiac Muscle Cell Apoptotic Process Negative Thymic T Cell Selection Negative T Cell Selection Transferase Complex Aggrephagy Striated Muscle Cell Apoptotic Process Regulation Of Autophagosome Maturation Mucus Secretion Negative Regulation Of Transport Nucleotide Binding Negative Regulation Of Defense Response To Virus
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