ATG5

Gene Name		autophagy related 5
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Gene Ontology Annotations	Cellular Component	Cytoplasm Autophagic Vacuole Axoneme Membrane Pre-autophagosomal Structure Membrane Atg12-Atg5-Atg16 Complex ER-mitochondrion Membrane Contact Site
	Molecular Function	Protein Binding Atg8 Ligase Activity
	Biological Process	Autophagic Vacuole Assembly Mitochondrion Degradation Blood Vessel Remodeling Regulation Of Cytokine Secretion Involved In Immune Response C-terminal Protein Lipidation Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Response To Fungus Negative Regulation Of Protein Ubiquitination Negative Regulation Of Type I Interferon Production Negative Stranded Viral RNA Replication Vasodilation Response To Drug Negative Regulation Of Apoptotic Process Post-translational Protein Modification Nucleophagy Innate Immune Response Otolith Development Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Ventricular Cardiac Muscle Cell Development Heart Contraction Positive Regulation Of Mucus Secretion Regulation Of Cilium Assembly Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Histone H4-K16 Acetylation
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling Innate Immune System
Drugs
Diseases
GWAS		Systemic lupus erythematosus ( 23273568 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-protein Interactions		11 interactors: ATG10 ATG12 ATG16L1 ATG3 CCHCR1 FADD KEAP1 MEOX2 TEKT4 VCP WDFY3
Entrez ID		9474
HPRD ID		16051
Ensembl ID		ENSG00000057663
Uniprot IDs		A9UGY9 Q9H1Y0
PDB IDs		4GDK 4GDL
Enriched GO Terms of Interacting Partners?		Autophagy Macroautophagy Cellular Response To Starvation Autophagic Vacuole Assembly Cellular Response To Nutrient Levels Response To Starvation Cellular Response To Extracellular Stimulus Catabolic Process Vacuole Organization Cellular Response To Stress Response To Nutrient Levels Response To Extracellular Stimulus Nucleophagy Mitochondrion Degradation Protein Modification By Small Protein Conjugation Organelle Disassembly Protein Transport Response To Stress Positive Regulation Of Proteolysis Establishment Of Protein Localization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Neuron Death Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Autophagy In Response To ER Overload Aggrephagy Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To External Stimulus Activation Of Cysteine-type Endopeptidase Activity Protein Oligomerization Motor Neuron Apoptotic Process Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Cell Death Cellular Component Assembly Death Protein Localization Zymogen Activation ER-nucleus Signaling Pathway Protein Lipidation Organelle Assembly Positive Regulation Of Cellular Protein Metabolic Process Lipoprotein Biosynthetic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity
Tagcloud ?		akt1 antipsychotic atg12 atg4b atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask