ATG5 and IRGM

Number of citations of the paper that reports this interaction (PubMedID 22174682)
49

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		ATG5	IRGM
Description		autophagy related 5	immunity related GTPase M
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Autophagosome Cytosol Axoneme Membrane Axon Phagocytic Vesicle Membrane Protein-containing Complex Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Synapse Phagophore Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse Transferase Complex	Golgi Membrane Autophagosome Membrane Phagocytic Cup Mitochondrion Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Mitochondrial Membrane Cell Projection
	Molecular Function	Protein Binding Atg8-family Ligase Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Protein Kinase Binding Protein-macromolecule Adaptor Activity Protein Serine/threonine Kinase Activator Activity CARD Domain Binding BH3 Domain Binding Cardiolipin Binding
	Biological Process	Autophagosome Assembly Mitophagy Blood Vessel Remodeling Immune System Process Regulation Of Cytokine Production Involved In Immune Response Chromatin Organization Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Cellular Response To Starvation Response To Xenobiotic Stimulus Response To Fungus Response To Iron(II) Ion Positive Regulation Of Autophagy Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Macroautophagy Protein Ubiquitination Antigen Processing And Presentation Of Endogenous Antigen Negative Regulation Of Protein Ubiquitination Negative Regulation Of Type I Interferon Production Piecemeal Microautophagy Of The Nucleus Aggrephagy Negative Stranded Viral RNA Replication Vasodilation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Post-translational Protein Modification Negative Thymic T Cell Selection Innate Immune Response Negative Regulation Of Innate Immune Response Otolith Development Negative Regulation Of Defense Response To Virus Negative Regulation Of Phagocytosis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Establishment Of Localization In Cell Ventricular Cardiac Muscle Cell Development Heart Contraction Chaperone-mediated Autophagy Positive Regulation Of Stress Granule Assembly Mucus Secretion Positive Regulation Of Mucus Secretion Cellular Response To Nitrosative Stress Axonal Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Autophagosome Maturation Regulation Of Cilium Assembly Response To Fluoride Negative Regulation Of Autophagic Cell Death Positive Regulation Of Viral Translation Regulation Of Reactive Oxygen Species Metabolic Process	Autophagosome Assembly Positive Regulation Of Protein Phosphorylation Immune System Process Autophagy Inflammatory Response Lysosome Organization Positive Regulation Of Autophagy Positive Regulation Of Peptidyl-threonine Phosphorylation Protein Catabolic Process Protein Destabilization Negative Regulation Of Type I Interferon Production Negative Regulation Of Type II Interferon Production Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interferon-beta Defense Response To Bacterium Positive Regulation Of Macrophage Activation Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly NLRP3 Inflammasome Complex Assembly Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus Negative Regulation Of Inflammatory Response Protein Stabilization Defense Response To Gram-negative Bacterium Positive Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Protein Complex Stability Protein Lipidation Involved In Autophagosome Assembly CAMKK-AMPK Signaling Cascade Protein-containing Complex Assembly Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Targeting To Vacuole Involved In Autophagy Cellular Response To Lipopolysaccharide Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Mitochondrial Fission Autophagosome Maturation Cellular Response To Virus Antibacterial Innate Immune Response Negative Regulation Of CGAS/STING Signaling Pathway Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Autophagosome Maturation Positive Regulation Of Mitophagy Positive Regulation Of Xenophagy Positive Regulation Of Lysosome Organization
Pathways		Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Glucose homeostasis traits ( 25524916) Limited cutaneous systemic scleroderma ( 24387989) Monobrow ( 27182965) Multiple myeloma ( 33875642 27363682) Rheumatoid arthritis ( 24390342 30423114) Systemic lupus erythematosus ( 28714469 19838193 27399966 26502338 23273568) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 31672989 24387989) Visceral fat ( 30942860) Youthful appearance (self-reported) ( 32339537)	Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 17554261 17554300 18587394 21102463 28067908) Dimensional psychopathology (Arousal) ( 29496196) Inflammatory bowel disease ( 23128233 28067908)
Interacting Genes		31 interacting genes: ATG10 ATG12 ATG16L1 ATG16L2 ATP23 CALCOCO2 CAPN1 CAPN2 CCHCR1 FADD FMR1 GRIPAP1 HOOK2 INCA1 IRGM KEAP1 KIAA1328 MAD1L1 MEOX2 MYC NLRP6 OPTN PSMB11 RACK1 TECPR1 TEKT4 TIAM1 TRIM21 USP13 VCP WDFY3	10 interacting genes: ATG10 ATG5 CGAS MAP1LC3C NLRP3 NOD1 NOD2 RIGI SH3GLB1 TLR3
Entrez ID		9474	345611
HPRD ID		16051	19559
Ensembl ID		ENSG00000057663	ENSG00000237693
Uniprot IDs		A0A2R8Y718 A9UGY9 Q7Z3H3 Q9H1Y0	A1A4Y4
PDB IDs		4GDK 4GDL 4NAW 4TQ0 4TQ1 5D7G 5NPV 5NPW 7W36
Enriched GO Terms of Interacting Partners?		Autophagy Macroautophagy Regulation Of Autophagy Autophagosome Atg12-Atg5-Atg16 Complex Catabolic Process Autophagosome Membrane Regulation Of Autophagosome Maturation Autophagosome Assembly Cytosol Vacuole Organization Positive Regulation Of Catabolic Process Autophagosome Organization Cytoplasm Protein-containing Complex Disassembly Identical Protein Binding Regulation Of Macroautophagy Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Autophagosome Maturation C-terminal Protein Lipidation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Viral Genome Replication Phagophore Assembly Site Membrane Macromolecule Catabolic Process Negative Stranded Viral RNA Replication Signaling Adaptor Activity Protein Transport Positive Regulation Of Autophagy Calpain Complex BAT3 Complex Binding Regulation Of Proteasomal Protein Catabolic Process Organelle Assembly Protein-containing Complex Binding Positive Regulation Of Protein Catabolic Process Negative Regulation Of Immune System Process BH3 Domain Binding Regulation Of Proteolysis Establishment Of Protein Localization Response To Virus Stress Granule Disassembly Xenophagy Positive Regulation Of Autophagosome Maturation Viral RNA Genome Replication Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Xenophagy Post-translational Protein Modification Protein Catabolic Process Positive Regulation Of Cellular Component Organization Protein-containing Complex Organization	Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of Cytokine Production Involved In Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Cytokine Production Involved In Immune Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Pattern Recognition Receptor Activity Autophagy Positive Regulation Of Innate Immune Response Innate Immune Response Immune Response-activating Signaling Pathway Defense Response To Symbiont Positive Regulation Of Interleukin-8 Production Immune Response-regulating Signaling Pathway Defense Response To Other Organism Response To Stress Activation Of Immune Response Regulation Of Cytokine Production Regulation Of Defense Response Positive Regulation Of Defense Response Cellular Response To Exogenous DsRNA Regulation Of Dendritic Cell Cytokine Production Intracellular Receptor Signaling Pathway Peptidoglycan Binding Positive Regulation Of Cytokine Production Regulation Of Interleukin-8 Production Regulation Of Immune Response Cellular Response To DsRNA Positive Regulation Of Interleukin-6 Production Positive Regulation Of Immune Effector Process Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Response To Other Organism Positive Regulation Of Immune Response Detection Of Biotic Stimulus Regulation Of Type I Interferon Production Immune Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Regulation Of Interleukin-6 Production Response To Exogenous DsRNA Response To Virus Response To External Biotic Stimulus Macroautophagy Defense Response Detection Of Virus Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Autophagy
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