ATG5 and ATG16L1

Number of citations of the paper that reports this interaction (PMID 12665549)
125

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		ATG5	ATG16L1
Gene Name		autophagy related 5	autophagy related 16-like 1 (S. cerevisiae)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Autophagic Vacuole Axoneme Membrane Pre-autophagosomal Structure Membrane Atg12-Atg5-Atg16 Complex ER-mitochondrion Membrane Contact Site	Autophagic Vacuole Membrane Autophagic Vacuole Axoneme Pre-autophagosomal Structure Membrane
	Molecular Function	Protein Binding Atg8 Ligase Activity	Protein Binding Identical Protein Binding
	Biological Process	Autophagic Vacuole Assembly Mitochondrion Degradation Blood Vessel Remodeling Regulation Of Cytokine Secretion Involved In Immune Response C-terminal Protein Lipidation Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Response To Fungus Negative Regulation Of Protein Ubiquitination Negative Regulation Of Type I Interferon Production Negative Stranded Viral RNA Replication Vasodilation Response To Drug Negative Regulation Of Apoptotic Process Post-translational Protein Modification Nucleophagy Innate Immune Response Otolith Development Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Ventricular Cardiac Muscle Cell Development Heart Contraction Positive Regulation Of Mucus Secretion Regulation Of Cilium Assembly Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Histone H4-K16 Acetylation	Autophagic Vacuole Assembly Protein Transport Negative Stranded Viral RNA Replication Protein Homooligomerization
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling Innate Immune System
Drugs
Diseases
GWAS		Systemic lupus erythematosus ( 23273568 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)	Crohn's disease ( 18587394 20570966 22936669 22412388 17435756 17554300 21102463 23128233)
Protein-Protein Interactions		11 interactors: ATG10 ATG12 ATG16L1 ATG3 CCHCR1 FADD KEAP1 MEOX2 TEKT4 VCP WDFY3	6 interactors: APP ATG5 RAB33A RAB33B TMEM59 UBC
Entrez ID		9474	55054
HPRD ID		16051	16498
Ensembl ID		ENSG00000057663	ENSG00000085978
Uniprot IDs		A9UGY9 Q9H1Y0	E7EVC7 Q17RG0 Q53SV2 Q676U5
PDB IDs		4GDK 4GDL	4GDK 4GDL
Enriched GO Terms of Interacting Partners?		Autophagy Macroautophagy Cellular Response To Starvation Autophagic Vacuole Assembly Cellular Response To Nutrient Levels Response To Starvation Cellular Response To Extracellular Stimulus Catabolic Process Vacuole Organization Cellular Response To Stress Response To Nutrient Levels Response To Extracellular Stimulus Nucleophagy Mitochondrion Degradation Protein Modification By Small Protein Conjugation Organelle Disassembly Protein Transport Response To Stress Positive Regulation Of Proteolysis Establishment Of Protein Localization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Neuron Death Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Autophagy In Response To ER Overload Aggrephagy Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To External Stimulus Activation Of Cysteine-type Endopeptidase Activity Protein Oligomerization Motor Neuron Apoptotic Process Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Cell Death Cellular Component Assembly Death Protein Localization Zymogen Activation ER-nucleus Signaling Pathway Protein Lipidation Organelle Assembly Positive Regulation Of Cellular Protein Metabolic Process Lipoprotein Biosynthetic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity	Regulation Of Autophagy Regulation Of Autophagic Vacuole Assembly Autophagy Regulation Of Vacuole Organization Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Type I Interferon Production Rab Protein Signal Transduction Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Intracellular Transport Negative Regulation Of Constitutive Secretory Pathway Negative Regulation Of Protein Ubiquitination Regulation Of Type I Interferon Production Catabolic Process Regulation Of Retrograde Vesicle-mediated Transport, Golgi To ER Synaptic Growth At Neuromuscular Junction Negative Regulation Of Protein Glycosylation In Golgi Notch Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Innate Immune Response Collateral Sprouting In Absence Of Injury Negative Regulation Of Cellular Metabolic Process Immune System Process Regulation Of Protein Metabolic Process Viral Life Cycle Negative Regulation Of Protein Glycosylation Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Protein Ubiquitination Negative Regulation Of Cytokine Production Collateral Sprouting Axon Midline Choice Point Recognition Apoptotic Process Ras Protein Signal Transduction Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Cellular Localization Regulation Of Cell Cycle Phase Transition Programmed Cell Death Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cellular Localization Cell Death Death Otolith Development Axon Choice Point Recognition
Tagcloud ?		akt1 antipsychotic atg12 atg4b atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask	1alpha 20a atg12 atg5 atg7 atg9a atgs autophagic autophagy becn1 cfos confirming ctsk decisive deregulation hif hypoxia hypoxic lc3 mirna mmp9 nfatc1 osteoclast p62 prime raw264 shrna traf6 utr
Tagcloud (Difference) ?		akt1 antipsychotic atg4b autophagosome autophagosomes bak1 bcl2l11 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask	1alpha 20a atg9a atgs cfos confirming ctsk decisive deregulation hif hypoxia hypoxic lc3 mirna mmp9 nfatc1 osteoclast p62 prime raw264 shrna traf6 utr
Tagcloud (Intersection) ?		atg12 atg5 atg7 autophagic autophagy becn1