ATG5 and KEAP1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ATG5	KEAP1
Gene Name		autophagy related 5	kelch-like ECH-associated protein 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Autophagic Vacuole Axoneme Membrane Pre-autophagosomal Structure Membrane Atg12-Atg5-Atg16 Complex ER-mitochondrion Membrane Contact Site	Nucleoplasm Cytoplasm Endoplasmic Reticulum Microtubule Organizing Center Cytosol Midbody Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Atg8 Ligase Activity	Protein Binding Transcription Factor Binding
	Biological Process	Autophagic Vacuole Assembly Mitochondrion Degradation Blood Vessel Remodeling Regulation Of Cytokine Secretion Involved In Immune Response C-terminal Protein Lipidation Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Response To Fungus Negative Regulation Of Protein Ubiquitination Negative Regulation Of Type I Interferon Production Negative Stranded Viral RNA Replication Vasodilation Response To Drug Negative Regulation Of Apoptotic Process Post-translational Protein Modification Nucleophagy Innate Immune Response Otolith Development Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Ventricular Cardiac Muscle Cell Development Heart Contraction Positive Regulation Of Mucus Secretion Regulation Of Cilium Assembly Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Histone H4-K16 Acetylation	In Utero Embryonic Development Transcription, DNA-templated Proteasomal Ubiquitin-independent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Epidermal Cell Differentiation Cellular Response To Interleukin-4
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling Innate Immune System	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Systemic lupus erythematosus ( 23273568 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-Protein Interactions		11 interactors: ATG10 ATG12 ATG16L1 ATG3 CCHCR1 FADD KEAP1 MEOX2 TEKT4 VCP WDFY3	38 interactors: AK4 AMER1 ATG5 BAD BPTF CAT CCNB1IP1 CLU DPP3 ETF1 FAM117B FAM46A GLRX5 GYPA IPO11 IRF1 KLHL3 KPNA6 LSM3 MAD2L1 MAPKBP1 MYO7A NFE2L2 NUDT4 OXR1 PDCD6IP PIDD1 PRKAG1 PRKCE PTMA RECK RELA SNRPN SQSTM1 TERF1 TSC22D4 WDR83 ZSCAN32
Entrez ID		9474	9817
HPRD ID		16051	12079
Ensembl ID		ENSG00000057663	ENSG00000079999
Uniprot IDs		A9UGY9 Q9H1Y0	Q14145
PDB IDs		4GDK 4GDL	1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4IN4 4IQK
Enriched GO Terms of Interacting Partners?		Autophagy Macroautophagy Cellular Response To Starvation Autophagic Vacuole Assembly Cellular Response To Nutrient Levels Response To Starvation Cellular Response To Extracellular Stimulus Catabolic Process Vacuole Organization Cellular Response To Stress Response To Nutrient Levels Response To Extracellular Stimulus Nucleophagy Mitochondrion Degradation Protein Modification By Small Protein Conjugation Organelle Disassembly Protein Transport Response To Stress Positive Regulation Of Proteolysis Establishment Of Protein Localization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Neuron Death Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Autophagy In Response To ER Overload Aggrephagy Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To External Stimulus Activation Of Cysteine-type Endopeptidase Activity Protein Oligomerization Motor Neuron Apoptotic Process Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Cell Death Cellular Component Assembly Death Protein Localization Zymogen Activation ER-nucleus Signaling Pathway Protein Lipidation Organelle Assembly Positive Regulation Of Cellular Protein Metabolic Process Lipoprotein Biosynthetic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity	Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Cell Death Nucleobase-containing Compound Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Virus Positive Regulation Of Interleukin-12 Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Cellular Response To Nicotine Apoptotic Process Response To Other Organism Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Programmed Cell Death Response To Biotic Stimulus Cell Death Death Regulation Of Interleukin-12 Biosynthetic Process ADP Metabolic Process Response To Reactive Oxygen Species Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Mucus Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Nitrogen Compound Metabolic Process Negative Regulation Of Chromosome Organization Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Response To Oxidative Stress Regulation Of Mucus Secretion Regulation Of Proteolysis Negative Regulation Of Cell Cycle Regulation Of Cell Division Regulation Of Type I Interferon Production Negative Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Response To Hydrogen Peroxide Response To Drug Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Macrophage Activation Metabolic Process Regulation Of Wound Healing
Tagcloud ?		akt1 antipsychotic atg12 atg4b atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask	acceptable acts antioxidant antioxidants cytoprotective ech enhances exerted extensive h2o2 hydrogen interference kelch maintained managed ndds neurodegenerative neuroprotection neurotoxicity nrf2 oxidative peroxide relieving represses rnai sirna speculated suffered u87mg
Tagcloud (Difference) ?		akt1 antipsychotic atg12 atg4b atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask	acceptable acts antioxidant antioxidants cytoprotective ech enhances exerted extensive h2o2 hydrogen interference kelch maintained managed ndds neurodegenerative neuroprotection neurotoxicity nrf2 oxidative peroxide relieving represses rnai sirna speculated suffered u87mg
Tagcloud (Intersection) ?