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ARHGEF6 and TGFBR2
Number of citations of the paper that reports this interaction (PubMedID
15761153
)
0
Data Source:
HPRD
(in vivo)
ARHGEF6
TGFBR2
Description
Rac/Cdc42 guanine nucleotide exchange factor 6
transforming growth factor beta receptor 2
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Cell-cell Junction
Lamellipodium
Cell Projection
Extracellular Region
Extracellular Space
Cytosol
Plasma Membrane
Caveola
External Side Of Plasma Membrane
Cell Surface
Membrane
Nuclear Body
Receptor Complex
Membrane Raft
Activin Receptor Complex
Transforming Growth Factor Beta Ligand-receptor Complex
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Protein Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Activity
Transforming Growth Factor Beta Receptor Activity, Type II
Protein Binding
ATP Binding
Glycosaminoglycan Binding
Kinase Activity
Activin Receptor Activity, Type I
Transferase Activity
Kinase Activator Activity
Type I Transforming Growth Factor Beta Receptor Binding
Type III Transforming Growth Factor Beta Receptor Binding
Signaling Receptor Activity
SMAD Binding
Metal Ion Binding
Activin Binding
Transforming Growth Factor Beta Binding
Molecular Adaptor Activity
Biological Process
Apoptotic Process
JNK Cascade
Lamellipodium Assembly
Blood Vessel Development
Branching Involved In Blood Vessel Morphogenesis
Vasculogenesis
In Utero Embryonic Development
Epithelial To Mesenchymal Transition
Heart Looping
Positive Regulation Of Mesenchymal Cell Proliferation
Lens Development In Camera-type Eye
Positive Regulation Of Tolerance Induction To Self Antigen
Positive Regulation Of B Cell Tolerance Induction
Positive Regulation Of T Cell Tolerance Induction
Outflow Tract Septum Morphogenesis
Membranous Septum Morphogenesis
Outflow Tract Morphogenesis
Aortic Valve Morphogenesis
Atrioventricular Valve Morphogenesis
Tricuspid Valve Morphogenesis
Cardiac Left Ventricle Morphogenesis
Endocardial Cushion Fusion
Growth Plate Cartilage Development
Growth Plate Cartilage Chondrocyte Growth
Apoptotic Process
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Notch Signaling Pathway
Smoothened Signaling Pathway
Gastrulation
Nervous System Development
Brain Development
Heart Development
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Epithelial To Mesenchymal Transition
Cell Differentiation
Lung Development
Activin Receptor Signaling Pathway
Response To Lipid
Embryonic Hemopoiesis
Aorta Morphogenesis
Regulation Of Cell Population Proliferation
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Angiogenesis
Animal Organ Development
Blood Vessel Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Artery Morphogenesis
Positive Regulation Of Developmental Process
Positive Regulation Of NK T Cell Differentiation
Cartilage Development
Regulation Of Multicellular Organismal Process
Roof Of Mouth Development
Positive Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Lung Morphogenesis
Bronchus Development
Bronchus Morphogenesis
Trachea Morphogenesis
Trachea Formation
Mammary Gland Morphogenesis
Lung Lobe Morphogenesis
Langerhans Cell Differentiation
Secondary Palate Development
Response To Cholesterol
Cellular Response To Growth Factor Stimulus
Regulation Of Stem Cell Proliferation
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Cell Proliferation Involved In Endocardial Cushion Morphogenesis
Superior Endocardial Cushion Morphogenesis
Inferior Endocardial Cushion Morphogenesis
Lens Fiber Cell Apoptotic Process
MiRNA Transport
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Regulation Of Stem Cell Differentiation
Pathways
NRAGE signals death through JNK
G alpha (12/13) signalling events
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
G beta:gamma signalling through CDC42
CDC42 GTPase cycle
RAC1 GTPase cycle
RHOU GTPase cycle
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
UCH proteinases
TGFBR3 regulates TGF-beta signaling
Drugs
Foreskin fibroblast (neonatal)
Foreskin keratinocyte (neonatal)
Fostamatinib
Diseases
Non-syndromic X-linked mental retardation
Loeys-Dietz syndrome (LDS)
Colorectal cancer
Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS
Autism spectrum disorder (
34069769
)
Breast cancer (
29059683
)
Breast cancer (
23535729
29059683
)
Cellular nuclear factor (erythroid-derived 2)-like 2 levels (
30767168
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Estimated glomerular filtration rate (
31152163
)
Heel bone mineral density (
30598549
)
Metabolite levels (
23823483
)
Migraine (
22683712
27322543
)
Migraine - clinic-based (
23793025
)
Night sleep phenotypes (
27126917
)
Postprandial triglyceride response (
32603185
)
Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) (
25117820
)
Systolic blood pressure (
30224653
)
Tonometry (
17903302
)
Interacting Genes
36 interacting genes:
ADAM15
ARAP3
ARHGEF7
BMPR1B
CAPNS1
CBFA2T3
CCDC33
CDC42
EPHB2
GIT1
GOLGA2
GPRASP2
HSF2BP
KRT27
NUTM1
PAK1
PAK2
PAK3
PARVB
PNMA1
POU6F2
RWDD2A
SH2D1A
SH3GL3
SIRPA
SMAD1
SMAD2
SMAD3
TGFBR1
TGFBR2
TMEM108
TP53BP2
TRAF2
TRIM54
YWHAG
ZNF580
51 interacting genes:
ACVR1
ACVRL1
AP2B1
APP
ARHGEF6
ARHGEF7
CCNB1
CCNB2
CD44
CDK1
CLU
CRIPTO
CTNNB1
DAB2
DAXX
DYNLT4
EIF3I
ENG
FANCC
GOPC
KCNK18
MAP2K1
NRP1
OSR1
PAK1
PDGFRA
PIK3R1
PIK3R2
PML
PPP2CB
PSMD14
RCVRN
SMAD3
SMAD4
SMAD7
SNX6
STRAP
TERT
TGFB1
TGFB1I1
TGFB2
TGFB3
TGFBR1
TGFBR3
TGFBRAP1
TRAP1
TRMO
TSSK1B
USP8
ZFYVE9
ZNF510
Entrez ID
9459
7048
HPRD ID
02226
01823
Ensembl ID
ENSG00000129675
ENSG00000163513
Uniprot IDs
B7Z3C7
Q15052
Q8N4Q3
A0AAQ5BI06
A3QNQ0
D2JYI1
P37173
PDB IDs
1UJY
1WYR
1KTZ
1M9Z
1PLO
2PJY
3KFD
4P7U
4XJJ
5E8V
5E8Y
5E91
5E92
5QIN
5TX4
5TY4
7DV6
8G4K
8YGZ
9B9F
9E9G
9FDY
9FK5
9FKP
Enriched GO Terms of Interacting Partners
?
Enzyme-linked Receptor Protein Signaling Pathway
Response To Growth Factor
Dendritic Spine Development
I-SMAD Binding
Cellular Response To Growth Factor Stimulus
Regulation Of Cytoskeleton Organization
Regulation Of Supramolecular Fiber Organization
Ephrin Receptor Signaling Pathway
SMAD Protein Signal Transduction
SMAD Protein Complex
Trophoblast Cell Migration
Heteromeric SMAD Protein Complex
Embryonic Cranial Skeleton Morphogenesis
Activin Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Regulation Of Stress Fiber Assembly
Co-SMAD Binding
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Primary MiRNA Processing
Transforming Growth Factor Beta Receptor Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
SMAD Binding
Protein Kinase Binding
Homomeric SMAD Protein Complex
Positive Regulation Of Stress Fiber Assembly
Regulation Of Actin Cytoskeleton Organization
Dendritic Spine Morphogenesis
Positive Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Microtubule Nucleation
Protein Kinase Activity
Positive Regulation Of Actin Filament Bundle Assembly
Cellular Response To Lectin
Stimulatory C-type Lectin Receptor Signaling Pathway
Paraxial Mesoderm Morphogenesis
Transforming Growth Factor Beta Ligand-receptor Complex
Regulation Of Actin Filament-based Process
Response To Transforming Growth Factor Beta
Immune System Process
Regulation Of Cartilage Development
Protein Serine/threonine Kinase Activity
Regulation Of Cellular Component Organization
Positive Regulation Of Cell Migration
Regulation Of Actin Filament Organization
Response To Cholesterol
Roof Of Mouth Development
Response To Stress
Positive Regulation Of Cell Motility
Regulation Of Organelle Organization
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Transforming Growth Factor Beta Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cellular Response To Growth Factor Stimulus
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of SMAD Protein Signal Transduction
Response To Growth Factor
Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
SMAD Binding
Regulation Of Apoptotic Process
Tissue Morphogenesis
Heart Development
Regulation Of Programmed Cell Death
Positive Regulation Of Developmental Process
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Type II Transforming Growth Factor Beta Receptor Binding
Regulation Of Signal Transduction
Tube Morphogenesis
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Transforming Growth Factor Beta Receptor Binding
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Anatomical Structure Morphogenesis
I-SMAD Binding
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Cell Motility
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Locomotion
Regulation Of Developmental Process
Regulation Of Growth
Regulation Of Cell Differentiation
Embryo Development Ending In Birth Or Egg Hatching
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Migration
Multicellular Organism Development
Regulation Of Cellular Component Organization
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Cell Differentiation
Transforming Growth Factor Beta Binding
Mesenchymal Cell Differentiation
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Tagcloud (Intersection)
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