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TGFBR2 and ARHGEF7
Number of citations of the paper that reports this interaction (PMID
15761153
)
154
Data Source:
HPRD
(in vivo)
TGFBR2
ARHGEF7
Gene Name
transforming growth factor, beta receptor II (70/80kDa)
Rho guanine nucleotide exchange factor (GEF) 7
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Plasma Membrane
Caveola
External Side Of Plasma Membrane
Integral Component Of Membrane
Receptor Complex
Transforming Growth Factor Beta Receptor Homodimeric Complex
Ruffle
Cytosol
Focal Adhesion
Cell Cortex
Lamellipodium
Neuron Projection
Neuronal Cell Body
Protein Complex
Molecular Function
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Receptor Signaling Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta-activated Receptor Activity
Transforming Growth Factor Beta Receptor Activity, Type II
Protein Binding
ATP Binding
Glycosaminoglycan Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Type I Transforming Growth Factor Beta Receptor Binding
Type III Transforming Growth Factor Beta Receptor Binding
SMAD Binding
Metal Ion Binding
Transforming Growth Factor Beta Binding
Guanyl-nucleotide Exchange Factor Activity
Rho Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Protein Kinase Binding
Biological Process
Blood Vessel Development
Patterning Of Blood Vessels
Vasculogenesis
In Utero Embryonic Development
Positive Regulation Of Mesenchymal Cell Proliferation
Lens Development In Camera-type Eye
Positive Regulation Of Tolerance Induction To Self Antigen
Positive Regulation Of B Cell Tolerance Induction
Positive Regulation Of T Cell Tolerance Induction
Growth Plate Cartilage Chondrocyte Growth
Protein Phosphorylation
Receptor-mediated Endocytosis
Apoptotic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Common-partner SMAD Protein Phosphorylation
Smoothened Signaling Pathway
Gastrulation
Brain Development
Heart Development
Embryo Implantation
Aging
Response To Nutrient
Positive Regulation Of Cell Proliferation
Response To Mechanical Stimulus
Response To Glucose
Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Signal Transduction By Phosphorylation
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Organ Regeneration
Activation Of Protein Kinase Activity
Embryonic Hemopoiesis
Wound Healing
Regulation Of Cell Proliferation
Response To Drug
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Skeletal Muscle Tissue Regeneration
Response To Estrogen
Positive Regulation Of Angiogenesis
Positive Regulation Of Smooth Muscle Cell Proliferation
Embryonic Cranial Skeleton Morphogenesis
Positive Regulation Of NK T Cell Differentiation
Palate Development
Negative Regulation Of Cardiac Muscle Cell Proliferation
Pathway-restricted SMAD Protein Phosphorylation
Bronchus Morphogenesis
Trachea Formation
Mammary Gland Morphogenesis
Lung Lobe Morphogenesis
Response To Cholesterol
Lens Fiber Cell Apoptotic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Hematopoietic Progenitor Cell Differentiation
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Axon Guidance
Positive Regulation Of Fibroblast Migration
Lamellipodium Assembly
Positive Regulation Of Rac GTPase Activity
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of GTPase Activity
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Focal Adhesion Assembly
Regulation Of Small GTPase Mediated Signal Transduction
Apoptotic Signaling Pathway
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Lamellipodium Morphogenesis
Pathways
Loss of Function of TGFBR2 in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Downregulation of TGF-beta receptor signaling
SMAD2/3 MH2 Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
TGF-beta receptor signaling activates SMADs
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by TGF-beta Receptor Complex
SMAD4 MH2 Domain Mutants in Cancer
EGFR downregulation
Signaling by GPCR
Signalling by NGF
Axon guidance
Cell death signalling via NRAGE, NRIF and NADE
Signaling by Ligand-Responsive EGFR Variants in Cancer
p75 NTR receptor-mediated signalling
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by EGFRvIII in Cancer
Rho GTPase cycle
Signaling by EGFR
GPCR downstream signaling
Ephrin signaling
NRAGE signals death through JNK
Signaling by Rho GTPases
Signaling by EGFR in Cancer
EPH-Ephrin signaling
G alpha (12/13) signalling events
Drugs
Glycerol
Diseases
GWAS
Breast cancer (
23535729
)
Migraine (
22683712
)
Tonometry (
17903302
)
Bilirubin levels (
19414484
)
Menarche (age at onset) (
21102462
)
Menopause (age at onset) (
19448619
)
Protein-Protein Interactions
44 interactors:
ACVR1
ACVRL1
AP2B1
APP
ARHGEF6
ARHGEF7
CBL
CCNB1
CCNB2
CD44
CDK1
CLU
CTNNB1
DAB2
DAXX
EIF3I
ENG
GOPC
KCNK18
NRP1
OSR1
PAK1
PDGFRA
PIK3R1
PIK3R2
PML
RCVRN
SMAD3
SMAD4
SMAD7
SNX6
STRAP
TCTEX1D4
TERT
TGFB1
TGFB1I1
TGFB2
TGFB3
TGFBR1
TGFBR3
TGFBRAP1
TRAP1
TSSK1B
ZFYVE9
28 interactors:
ADAM15
ARHGEF6
CALM1
CBLB
CD244
CDC42
ERBB2IP
GIT1
GIT2
LRRK2
MEOX2
NCK1
NCKIPSD
PAK1
PAK2
PAK3
PPM1E
PPM1F
PXN
RAC1
SCRIB
SH2D1A
SHANK1
SHANK2
TGFBR2
TUBB3
WAS
YWHAG
Entrez ID
7048
8874
HPRD ID
01823
05688
Ensembl ID
ENSG00000163513
ENSG00000102606
Uniprot IDs
A3QNQ0
D2JYI1
P37173
B7Z6G2
E9PDQ5
Q14155
PDB IDs
1KTZ
1M9Z
1PLO
2PJY
3KFD
1BY1
1ZSG
2L3G
Enriched GO Terms of Interacting Partners
?
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Transforming Growth Factor Beta Stimulus
Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Transforming Growth Factor Beta
Regulation Of Signal Transduction
Cellular Response To Organic Substance
Regulation Of Signaling
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Regulation Of Phosphorylation
Regulation Of Epithelial To Mesenchymal Transition
Response To Organic Substance
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Regulation Of Protein Phosphorylation
Positive Regulation Of Signal Transduction
Regulation Of Cellular Response To Growth Factor Stimulus
Cell Surface Receptor Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Signal Transduction
Negative Regulation Of Signaling
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Catalytic Activity
Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Tube Development
Response To Wounding
Regulation Of Cell Death
Signaling
Positive Regulation Of Phosphorylation
Regulation Of Cell Differentiation
Cellular Response To Stimulus
Signal Transduction
Cell Communication
Response To Stress
Regulation Of Gene Expression
Regulation Of Apoptotic Process
Tissue Morphogenesis
Anatomical Structure Morphogenesis
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Kinase Activity
Regulation Of Catalytic Activity
Cell Morphogenesis Involved In Differentiation
Regulation Of Protein Kinase Activity
Regulation Of Signaling
Cell Morphogenesis
Regulation Of Protein Phosphorylation
Regulation Of Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signaling
Cell Projection Organization
Enzyme Linked Receptor Protein Signaling Pathway
Response To Stimulus
Cell Communication
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Catalytic Activity
Regulation Of Phosphorylation
Fc Receptor Signaling Pathway
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of Programmed Cell Death
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Death
Regulation Of Cell Adhesion
Regulation Of T Cell Activation
Neuron Projection Morphogenesis
Immune Response-regulating Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Organelle Organization
Positive Regulation Of Kinase Activity
Regulation Of Phosphorus Metabolic Process
Cell Development
Movement Of Cell Or Subcellular Component
Regulation Of Cytoskeleton Organization
Positive Regulation Of T Cell Activation
Neuron Development
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Homotypic Cell-cell Adhesion
Regulation Of Actin Cytoskeleton Organization
Nervous System Development
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Regulation Of Immune System Process
Positive Regulation Of Transferase Activity
Axon Guidance
Regulation Of Lymphocyte Activation
Positive Regulation Of Cell-cell Adhesion
Anatomical Structure Morphogenesis
Regulation Of Actin Filament-based Process
Neuron Projection Development
Tagcloud
?
aaa
adventitial
alleles
aneurysm
aortas
aortic
betatype
disruption
elastase
elastin
fourteen
genetical
infiltration
infrarenal
medial
metalloproteinases
myhcre
peri
principal
prominently
resident
sm
smc
smooth
transforming
wise
Tagcloud (Difference)
?
aaa
adventitial
alleles
aneurysm
aortas
aortic
betatype
disruption
elastase
elastin
fourteen
genetical
infiltration
infrarenal
medial
metalloproteinases
myhcre
peri
principal
prominently
resident
sm
smc
smooth
transforming
wise
Tagcloud (Intersection)
?