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TGFBR2 and SMAD7
Number of citations of the paper that reports this interaction (PubMedID
25149540
)
45
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo, in vitro)
TGFBR2
SMAD7
Description
transforming growth factor beta receptor 2
SMAD family member 7
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytosol
Plasma Membrane
Caveola
External Side Of Plasma Membrane
Cell Surface
Membrane
Nuclear Body
Receptor Complex
Membrane Raft
Activin Receptor Complex
Transforming Growth Factor Beta Ligand-receptor Complex
Chromatin
Fibrillar Center
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Centrosome
Cytosol
Plasma Membrane
Adherens Junction
Protein-containing Complex
Ciliary Basal Body
Heteromeric SMAD Protein Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Activity
Transforming Growth Factor Beta Receptor Activity, Type II
Protein Binding
ATP Binding
Glycosaminoglycan Binding
Kinase Activity
Activin Receptor Activity, Type I
Transferase Activity
Kinase Activator Activity
Type I Transforming Growth Factor Beta Receptor Binding
Type III Transforming Growth Factor Beta Receptor Binding
Signaling Receptor Activity
SMAD Binding
Metal Ion Binding
Activin Binding
Transforming Growth Factor Beta Binding
Molecular Adaptor Activity
Transcription Corepressor Activity
Protein Binding
Collagen Binding
Beta-catenin Binding
Ubiquitin Protein Ligase Binding
Type I Transforming Growth Factor Beta Receptor Binding
Metal Ion Binding
I-SMAD Binding
Activin Receptor Binding
Transcription Regulator Inhibitor Activity
Ubiquitin-like Ligase-substrate Adaptor Activity
Biological Process
Blood Vessel Development
Branching Involved In Blood Vessel Morphogenesis
Vasculogenesis
In Utero Embryonic Development
Epithelial To Mesenchymal Transition
Heart Looping
Positive Regulation Of Mesenchymal Cell Proliferation
Lens Development In Camera-type Eye
Positive Regulation Of Tolerance Induction To Self Antigen
Positive Regulation Of B Cell Tolerance Induction
Positive Regulation Of T Cell Tolerance Induction
Outflow Tract Septum Morphogenesis
Membranous Septum Morphogenesis
Outflow Tract Morphogenesis
Aortic Valve Morphogenesis
Atrioventricular Valve Morphogenesis
Tricuspid Valve Morphogenesis
Cardiac Left Ventricle Morphogenesis
Endocardial Cushion Fusion
Growth Plate Cartilage Development
Growth Plate Cartilage Chondrocyte Growth
Apoptotic Process
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Notch Signaling Pathway
Smoothened Signaling Pathway
Gastrulation
Nervous System Development
Brain Development
Heart Development
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Epithelial To Mesenchymal Transition
Cell Differentiation
Lung Development
Activin Receptor Signaling Pathway
Response To Lipid
Embryonic Hemopoiesis
Aorta Morphogenesis
Regulation Of Cell Population Proliferation
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Angiogenesis
Animal Organ Development
Blood Vessel Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Artery Morphogenesis
Positive Regulation Of Developmental Process
Positive Regulation Of NK T Cell Differentiation
Cartilage Development
Regulation Of Multicellular Organismal Process
Roof Of Mouth Development
Positive Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Lung Morphogenesis
Bronchus Development
Bronchus Morphogenesis
Trachea Morphogenesis
Trachea Formation
Mammary Gland Morphogenesis
Lung Lobe Morphogenesis
Langerhans Cell Differentiation
Secondary Palate Development
Response To Cholesterol
Cellular Response To Growth Factor Stimulus
Regulation Of Stem Cell Proliferation
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Cell Proliferation Involved In Endocardial Cushion Morphogenesis
Superior Endocardial Cushion Morphogenesis
Inferior Endocardial Cushion Morphogenesis
Lens Fiber Cell Apoptotic Process
MiRNA Transport
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Regulation Of Stem Cell Differentiation
Negative Regulation Of Transcription By RNA Polymerase II
Ureteric Bud Development
Negative Regulation Of T Cell Cytokine Production
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
Anatomical Structure Morphogenesis
Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Transcription By Competitive Promoter Binding
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cell Differentiation
Negative Regulation Of Ossification
Negative Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Protein-containing Complex Localization
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Activin Receptor Signaling Pathway
Protein-containing Complex Disassembly
Adherens Junction Assembly
Response To Laminar Fluid Shear Stress
Negative Regulation Of Cell Differentiation
Artery Morphogenesis
Protein Stabilization
Ventricular Cardiac Muscle Tissue Morphogenesis
Regulation Of Cardiac Muscle Contraction
Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization
Negative Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Cellular Response To Growth Factor Stimulus
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Negative Regulation Of Chondrocyte Proliferation
Positive Regulation Of Chondrocyte Hypertrophy
Beta-catenin Destruction Complex Disassembly
Cellular Response To Leukemia Inhibitory Factor
Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Negative Regulation Of T-helper 17 Type Immune Response
Negative Regulation Of T-helper 17 Cell Differentiation
Pathways
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
UCH proteinases
TGFBR3 regulates TGF-beta signaling
Signaling by BMP
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
UCH proteinases
Ub-specific processing proteases
Interferon gamma signaling
Drugs
Foreskin fibroblast (neonatal)
Foreskin keratinocyte (neonatal)
Fostamatinib
Diseases
Loeys-Dietz syndrome (LDS)
Colorectal cancer
Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS
Breast cancer (
23535729
29059683
)
Cellular nuclear factor (erythroid-derived 2)-like 2 levels (
30767168
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Estimated glomerular filtration rate (
31152163
)
Heel bone mineral density (
30598549
)
Metabolite levels (
23823483
)
Migraine (
22683712
27322543
)
Migraine - clinic-based (
23793025
)
Night sleep phenotypes (
27126917
)
Postprandial triglyceride response (
32603185
)
Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) (
25117820
)
Systolic blood pressure (
30224653
)
Tonometry (
17903302
)
Asthma (
32296059
)
Atrial fibrillation (
29892015
30061737
)
Colorectal cancer (
24836286
29471430
29228715
17934461
30529582
26151821
25990418
24448986
23266556
31826910
21761138
18372905
18372901
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
33020668
)
Creatinine levels (
29403010
)
Dental caries (
23064961
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Estimated glomerular filtration rate (
30604766
31015462
31152163
)
Glomerular filtration rate (
29403010
)
Heel bone mineral density (
30598549
)
Hematocrit (
27863252
32888494
)
Hemoglobin (
32888494
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
Inflammatory bowel disease (
23128233
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Myocardial infarction (
33532862
)
Parental longevity (at least one long-lived parent) (
27816938
)
Red blood cell count (
32888494
27863252
)
Serum alkaline phosphatase levels (
33547301
)
Interacting Genes
51 interacting genes:
ACVR1
ACVRL1
AP2B1
APP
ARHGEF6
ARHGEF7
CCNB1
CCNB2
CD44
CDK1
CLU
CRIPTO
CTNNB1
DAB2
DAXX
DYNLT4
EIF3I
ENG
FANCC
GOPC
KCNK18
MAP2K1
NRP1
OSR1
PAK1
PDGFRA
PIK3R1
PIK3R2
PML
PPP2CB
PSMD14
RCVRN
SMAD3
SMAD4
SMAD7
SNX6
STRAP
TERT
TGFB1
TGFB1I1
TGFB2
TGFB3
TGFBR1
TGFBR3
TGFBRAP1
TRAP1
TRMO
TSSK1B
USP8
ZFYVE9
ZNF510
58 interacting genes:
ACVR1B
AKT1
ASH1L
AXIN1
AXIN2
BMPR1B
CBL
CTNNB1
CXXC5
DVL1
EP300
ERBIN
HAT1
HEYL
KDM2A
MAP2K3
MAP2K6
MAP3K7
MAPK14
MBD1
MRTFB
MYOD1
NEDD4L
PARD3
PIAS1
PIAS4
RNF111
SASH3
SETD7
SIRT1
SMAD2
SMAD3
SMAD4
SMAD6
SMURF1
SMURF2
SOX13
SOX5
SOX7
STAMBP
STAMBPL1
STRAP
TAB1
TGFB1I1
TGFBR1
TGFBR2
TTF1
TTF2
UBE2L3
UCHL5
USP2
WWP2
XRCC6
YAP1
ZBTB11
ZBTB44
ZEB1
ZNF107
Entrez ID
7048
4092
HPRD ID
01823
04241
Ensembl ID
ENSG00000163513
ENSG00000101665
Uniprot IDs
A0AAQ5BI06
A3QNQ0
D2JYI1
P37173
B3KYA8
O15105
PDB IDs
1KTZ
1M9Z
1PLO
2PJY
3KFD
4P7U
4XJJ
5E8V
5E8Y
5E91
5E92
5QIN
5TX4
5TY4
7DV6
8G4K
8YGZ
9B9F
9E9G
9FDY
9FK5
9FKP
2DJY
2KXQ
2LTV
2LTW
2LTX
2LTY
2LTZ
Enriched GO Terms of Interacting Partners
?
Transforming Growth Factor Beta Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cellular Response To Growth Factor Stimulus
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of SMAD Protein Signal Transduction
Response To Growth Factor
Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
SMAD Binding
Regulation Of Apoptotic Process
Tissue Morphogenesis
Heart Development
Regulation Of Programmed Cell Death
Positive Regulation Of Developmental Process
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Type II Transforming Growth Factor Beta Receptor Binding
Regulation Of Signal Transduction
Tube Morphogenesis
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Transforming Growth Factor Beta Receptor Binding
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Anatomical Structure Morphogenesis
I-SMAD Binding
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Cell Motility
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Locomotion
Regulation Of Developmental Process
Regulation Of Growth
Regulation Of Cell Differentiation
Embryo Development Ending In Birth Or Egg Hatching
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Migration
Multicellular Organism Development
Regulation Of Cellular Component Organization
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Cell Differentiation
Transforming Growth Factor Beta Binding
Mesenchymal Cell Differentiation
I-SMAD Binding
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
SMAD Binding
Regulation Of Signal Transduction
Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cell Differentiation
Positive Regulation Of Developmental Process
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Growth Factor
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Macromolecule Metabolic Process
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Developmental Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Regulation Of Cell Differentiation
Ubiquitin Protein Ligase Binding
Tissue Development
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Signal Transduction
Regulation Of Multicellular Organismal Process
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Nucleus
Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Biosynthetic Process
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Signal Transduction
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cell Communication
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Tagcloud (Intersection)
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