ARHGEF6 and GPRASP2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		ARHGEF6	GPRASP2
Gene Name		Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	G protein-coupled receptor associated sorting protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Cytosol Cell-cell Junction Lamellipodium	Cytoplasm
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Beta-amyloid Binding
	Biological Process	Apoptotic Process JNK Cascade Small GTPase Mediated Signal Transduction Lamellipodium Assembly Positive Regulation Of Rho GTPase Activity Cell Junction Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Signaling by GPCR Cell junction organization Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G alpha (12/13) signalling events Cell-extracellular matrix interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		22 interactors: ADAM15 ARHGEF7 BMPR1B CAPNS1 CDC42 EPHB2 GIT1 GPRASP2 PAK1 PAK2 PAK3 PARVB SH2D1A SH3GL3 SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 YWHAG ZNF580	25 interactors: ADRB1 ARHGEF6 BARD1 BZRAP1 C6orf165 CALCR CBX8 CHRM1 CHRM2 DISC1 FRAT1 HAP1 HRH2 HTR7 HTT KIAA1377 LOC149950 LRIF1 MYOT PTN RPS6KA5 STMN2 TCF25 TXN TXN2
Entrez ID		9459	114928
HPRD ID		02226	06612
Ensembl ID		ENSG00000129675	ENSG00000158301
Uniprot IDs		B7Z3C7 Q15052 Q8N4Q3	B3KW05 Q96D09
PDB IDs		1UJY 1WYR
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Morphogenesis Cell Morphogenesis Involved In Differentiation Ephrin Receptor Signaling Pathway Cell Development Intracellular Signal Transduction Anatomical Structure Morphogenesis Axon Guidance Chemotaxis Signal Transduction By Phosphorylation Positive Regulation Of Cell Morphogenesis Involved In Differentiation Cell Differentiation Nervous System Development System Development Cell Morphogenesis Axonogenesis Primary MiRNA Processing Regulation Of Cellular Component Organization Axon Development Generation Of Neurons Positive Regulation Of Cell Differentiation Regulation Of Cell Development Regulation Of Signaling Regulation Of Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Apoptotic Process Cell Morphogenesis Involved In Neuron Differentiation Cell Surface Receptor Signaling Pathway Positive Regulation Of Programmed Cell Death SMAD Protein Complex Assembly Positive Regulation Of Cell Death Regulation Of Cell Adhesion Neurogenesis Locomotion Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Neuron Projection Morphogenesis Multicellular Organismal Development Signaling Regulation Of Signal Transduction Cell Communication Anatomical Structure Development Response To External Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Growth Positive Regulation Of Cell Development Regulation Of Cell Proliferation Heart Development Embryonic Cranial Skeleton Morphogenesis Signal Transduction	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Cell-cell Signaling Homeostatic Process Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cation Channel Activity Cell Communication Cellular Response To Stimulus Cognition Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Synaptic Transmission Positive Regulation Of Ion Transmembrane Transporter Activity Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Transporter Activity Signaling Positive Regulation Of Ion Transport Cellular Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Positive Regulation Of Ion Transmembrane Transport Regulation Of Cation Channel Activity Signal Transduction G-protein Coupled Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Learning Or Memory Response To Stimulus Glycerol Ether Metabolic Process Cell Redox Homeostasis Memory Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Cellular Process Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Secretion Learning Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Protein Export From Nucleus Vasoconstriction Developmental Process Vesicle Transport Along Microtubule Positive Regulation Of Adenylate Cyclase Activity Anatomical Structure Development Regulation Of Intracellular Transport Positive Regulation Of Receptor Activity Regulation Of Calcium Ion Transport Single-organism Behavior Response To Reactive Oxygen Species Nervous System Development Positive Regulation Of Signal Transduction
Tagcloud ?		acted analyzing bioinformatic constructed crc dataset david degs disturbed downloaded fzd2 gse23878 hprd hub intend jup kegg module modules networks omnibus pdgfrb prkcb student theses uncovered wnt11 wnt2 wnt5a
Tagcloud (Difference) ?		acted analyzing bioinformatic constructed crc dataset david degs disturbed downloaded fzd2 gse23878 hprd hub intend jup kegg module modules networks omnibus pdgfrb prkcb student theses uncovered wnt11 wnt2 wnt5a
Tagcloud (Intersection) ?