ARHGEF6 and TMEM108

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		ARHGEF6	TMEM108
Description		Rac/Cdc42 guanine nucleotide exchange factor 6	transmembrane protein 108
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cell-cell Junction Lamellipodium Cell Projection	Endosome Early Endosome Endosome Membrane Postsynaptic Density Membrane Axon Dendrite Somatodendritic Compartment Cell Projection Synapse Postsynaptic Density Membrane Glutamatergic Synapse Axon Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Protein Binding
	Biological Process	Apoptotic Process JNK Cascade Lamellipodium Assembly	Receptor-mediated Endocytosis Retrograde Axonal Transport Dentate Gyrus Development Neuron Projection Development Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Postsynaptic Density Organization Dendrite Extension Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Modulation Of Excitatory Postsynaptic Potential Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RHOU GTPase cycle
Drugs
Diseases		Non-syndromic X-linked mental retardation
GWAS		Autism spectrum disorder ( 34069769) Breast cancer ( 29059683)	Bipolar disorder ( 33263727) Chronotype ( 30696823) Daytime nap ( 33568662) Femur bone mineral density x serum urate levels interaction ( 34046847) IgE grass sensitization ( 22036096) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Menarche (age at onset) ( 21102462 27182965) Parkinson's disease progression (cognitive) ( 33958783) Stroke ( 32693751) Systolic blood pressure ( 30224653 30578418) Waist circumference ( 28552196)
Interacting Genes		36 interacting genes: ADAM15 ARAP3 ARHGEF7 BMPR1B CAPNS1 CBFA2T3 CCDC33 CDC42 EPHB2 GIT1 GOLGA2 GPRASP2 HSF2BP KRT27 NUTM1 PAK1 PAK2 PAK3 PARVB PNMA1 POU6F2 RWDD2A SH2D1A SH3GL3 SIRPA SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 TP53BP2 TRAF2 TRIM54 YWHAG ZNF580	7 interacting genes: ANXA7 ARHGEF6 FHL3 FKBP7 NOTCH3 SGTB SH3GL2
Entrez ID		9459	66000
HPRD ID		02226	11329
Ensembl ID		ENSG00000129675	ENSG00000144868
Uniprot IDs		B7Z3C7 Q15052 Q8N4Q3	B3KT64 Q6UXF1
PDB IDs		1UJY 1WYR
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Response To Growth Factor Dendritic Spine Development I-SMAD Binding Cellular Response To Growth Factor Stimulus Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Ephrin Receptor Signaling Pathway SMAD Protein Signal Transduction SMAD Protein Complex Trophoblast Cell Migration Heteromeric SMAD Protein Complex Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Stress Fiber Assembly Co-SMAD Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Primary MiRNA Processing Transforming Growth Factor Beta Receptor Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Binding Protein Kinase Binding Homomeric SMAD Protein Complex Positive Regulation Of Stress Fiber Assembly Regulation Of Actin Cytoskeleton Organization Dendritic Spine Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Microtubule Nucleation Protein Kinase Activity Positive Regulation Of Actin Filament Bundle Assembly Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Paraxial Mesoderm Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Regulation Of Actin Filament-based Process Response To Transforming Growth Factor Beta Immune System Process Regulation Of Cartilage Development Protein Serine/threonine Kinase Activity Regulation Of Cellular Component Organization Positive Regulation Of Cell Migration Regulation Of Actin Filament Organization Response To Cholesterol Roof Of Mouth Development Response To Stress Positive Regulation Of Cell Motility Regulation Of Organelle Organization Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
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