TGFBR2 and TCTEX1D4

Number of citations of the paper that reports this interaction (PMID 16982625)
11

Data Source:
HPRD (two hybrid, in vivo)

		TGFBR2	TCTEX1D4
Gene Name		transforming growth factor, beta receptor II (70/80kDa)	Tctex1 domain containing 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Caveola External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex Transforming Growth Factor Beta Receptor Homodimeric Complex	Acrosomal Vesicle Nucleus Microtubule Organizing Center Axoneme Sperm Flagellum
	Molecular Function	Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type II Protein Binding ATP Binding Glycosaminoglycan Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding SMAD Binding Metal Ion Binding Transforming Growth Factor Beta Binding	Protein Binding
	Biological Process	Blood Vessel Development Patterning Of Blood Vessels Vasculogenesis In Utero Embryonic Development Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Positive Regulation Of Tolerance Induction To Self Antigen Positive Regulation Of B Cell Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Growth Plate Cartilage Chondrocyte Growth Protein Phosphorylation Receptor-mediated Endocytosis Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation Smoothened Signaling Pathway Gastrulation Brain Development Heart Development Embryo Implantation Aging Response To Nutrient Positive Regulation Of Cell Proliferation Response To Mechanical Stimulus Response To Glucose Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Organ Regeneration Activation Of Protein Kinase Activity Embryonic Hemopoiesis Wound Healing Regulation Of Cell Proliferation Response To Drug Myeloid Dendritic Cell Differentiation Positive Regulation Of Skeletal Muscle Tissue Regeneration Response To Estrogen Positive Regulation Of Angiogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of NK T Cell Differentiation Palate Development Negative Regulation Of Cardiac Muscle Cell Proliferation Pathway-restricted SMAD Protein Phosphorylation Bronchus Morphogenesis Trachea Formation Mammary Gland Morphogenesis Lung Lobe Morphogenesis Response To Cholesterol Lens Fiber Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs		Glycerol
Diseases
GWAS		Breast cancer ( 23535729) Migraine ( 22683712) Tonometry ( 17903302)
Protein-Protein Interactions		44 interactors: ACVR1 ACVRL1 AP2B1 APP ARHGEF6 ARHGEF7 CBL CCNB1 CCNB2 CD44 CDK1 CLU CTNNB1 DAB2 DAXX EIF3I ENG GOPC KCNK18 NRP1 OSR1 PAK1 PDGFRA PIK3R1 PIK3R2 PML RCVRN SMAD3 SMAD4 SMAD7 SNX6 STRAP TCTEX1D4 TERT TGFB1 TGFB1I1 TGFB2 TGFB3 TGFBR1 TGFBR3 TGFBRAP1 TRAP1 TSSK1B ZFYVE9	6 interactors: ACVR2A ENG PPP1CA PPP1CC TGFBR2 TGFBR3
Entrez ID		7048	343521
HPRD ID		01823	15762
Ensembl ID		ENSG00000163513	ENSG00000188396
Uniprot IDs		A3QNQ0 D2JYI1 P37173	Q5JR98
PDB IDs		1KTZ 1M9Z 1PLO 2PJY 3KFD
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Response To Transforming Growth Factor Beta Regulation Of Signal Transduction Cellular Response To Organic Substance Regulation Of Signaling Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Regulation Of Epithelial To Mesenchymal Transition Response To Organic Substance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Tube Development Response To Wounding Regulation Of Cell Death Signaling Positive Regulation Of Phosphorylation Regulation Of Cell Differentiation Cellular Response To Stimulus Signal Transduction Cell Communication Response To Stress Regulation Of Gene Expression Regulation Of Apoptotic Process Tissue Morphogenesis Anatomical Structure Morphogenesis	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance BMP Signaling Pathway Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Response To Organic Substance Negative Regulation Of Signaling Regulation Of Signal Transduction Phosphate-containing Compound Metabolic Process Pathway-restricted SMAD Protein Phosphorylation Regulation Of Signaling Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Tissue Morphogenesis Triglyceride Catabolic Process Tissue Development Branching Morphogenesis Of An Epithelial Tube Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Nitric-oxide Synthase Activity Cellular Protein Metabolic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Patterning Of Blood Vessels Anatomical Structure Morphogenesis Embryo Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Epithelial Tube Morphogenesis Regulation Of Gene Expression Glycogen Metabolic Process Positive Regulation Of Signal Transduction Tube Morphogenesis Signal Transduction Protein Phosphorylation Organ Regeneration Regulation Of Oxidoreductase Activity
Tagcloud ?		aaa adventitial alleles aneurysm aortas aortic betatype disruption elastase elastin fourteen genetical infiltration infrarenal medial metalloproteinases myhcre peri principal prominently resident sm smc smooth transforming wise
Tagcloud (Difference) ?		aaa adventitial alleles aneurysm aortas aortic betatype disruption elastase elastin fourteen genetical infiltration infrarenal medial metalloproteinases myhcre peri principal prominently resident sm smc smooth transforming wise
Tagcloud (Intersection) ?