ARHGEF6 and EPHB2

Number of citations of the paper that reports this interaction (PubMedID 10523848)
0

Data Source:
HPRD (in vitro)

		ARHGEF6	EPHB2
Description		Rac/Cdc42 guanine nucleotide exchange factor 6	EPH receptor B2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cell-cell Junction Lamellipodium Cell Projection	Extracellular Region Nucleoplasm Cytosol Plasma Membrane Cell Surface Membrane Axon Dendrite Presynaptic Membrane Cell Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Postsynapse Glutamatergic Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Nucleotide Binding Amyloid-beta Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Signaling Receptor Binding Protein Binding ATP Binding Axon Guidance Receptor Activity Kinase Activity Transferase Activity Signaling Receptor Activity Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Apoptotic Process JNK Cascade Lamellipodium Assembly	Cell Morphogenesis Angiogenesis Urogenital System Development Positive Regulation Of Immunoglobulin Production Negative Regulation Of Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axonogenesis Axon Guidance Axonal Fasciculation Learning Or Memory Learning Animal Organ Morphogenesis Positive Regulation Of Gene Expression Phosphorylation Peptidyl-tyrosine Phosphorylation Optic Nerve Morphogenesis Hindbrain Tangential Cell Migration Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Retinal Ganglion Cell Axon Guidance Positive Regulation Of Synaptic Plasticity Positive Regulation Of Tumor Necrosis Factor Production B Cell Activation Inner Ear Morphogenesis Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Ras Protein Signal Transduction Ephrin Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Camera-type Eye Morphogenesis Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Regulation Of Body Fluid Levels Positive Regulation Of Multicellular Organismal Process Regulation Of Filopodium Assembly Regulation Of Synapse Assembly Positive Regulation Of Synapse Assembly Roof Of Mouth Development Dendritic Spine Development Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Commissural Neuron Axon Guidance Postsynaptic Membrane Assembly Neuron Projection Retraction Vesicle-mediated Intercellular Transport Tight Junction Assembly Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Cellular Response To Amyloid-beta Neuron Projection Maintenance Positive Regulation Of Protein Localization To Cell Surface Regulation Of T-helper 17 Type Immune Response Regulation Of Autophagosome Assembly Regulation Of Behavioral Fear Response
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RHOU GTPase cycle	EPH-Ephrin signaling EPH-Ephrin signaling L1CAM interactions EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs			Phosphoaminophosphonic Acid-Adenylate Ester Fostamatinib Oleandrin
Diseases		Non-syndromic X-linked mental retardation
GWAS		Autism spectrum disorder ( 34069769) Breast cancer ( 29059683)	Blood protein levels ( 30072576) Refractive error ( 32231278) Triiodothyronine levels ( 30843173) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		36 interacting genes: ADAM15 ARAP3 ARHGEF7 BMPR1B CAPNS1 CBFA2T3 CCDC33 CDC42 EPHB2 GIT1 GOLGA2 GPRASP2 HSF2BP KRT27 NUTM1 PAK1 PAK2 PAK3 PARVB PNMA1 POU6F2 RWDD2A SH2D1A SH3GL3 SIRPA SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 TP53BP2 TRAF2 TRIM54 YWHAG ZNF580	40 interacting genes: ABL1 ABL2 ACP1 AFDN APP AQP1 ARHGEF6 CRK EFNA5 EFNB1 EFNB2 ERF FBXO7 FOS GRB2 GRIN1 GRIN2B ITSN1 KALRN KSR1 MMP2 MMP9 MTMR14 NCK1 PICK1 PLCG1 PTK2 RASA1 RNF186 RRAS RYK SDC2 SDCBP SH2D3C SRC SYNJ1 TRIM54 VAV2 VEGFA YES1
Entrez ID		9459	2048
HPRD ID		02226	02997
Ensembl ID		ENSG00000129675	ENSG00000133216
Uniprot IDs		B7Z3C7 Q15052 Q8N4Q3	B4DSE0 P29323 Q6NVW1
PDB IDs		1UJY 1WYR	1B4F 1F0M 2QBX 3ZFM 8EBL
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Response To Growth Factor Dendritic Spine Development I-SMAD Binding Cellular Response To Growth Factor Stimulus Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Ephrin Receptor Signaling Pathway SMAD Protein Signal Transduction SMAD Protein Complex Trophoblast Cell Migration Heteromeric SMAD Protein Complex Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Stress Fiber Assembly Co-SMAD Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Primary MiRNA Processing Transforming Growth Factor Beta Receptor Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Binding Protein Kinase Binding Homomeric SMAD Protein Complex Positive Regulation Of Stress Fiber Assembly Regulation Of Actin Cytoskeleton Organization Dendritic Spine Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Microtubule Nucleation Protein Kinase Activity Positive Regulation Of Actin Filament Bundle Assembly Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Paraxial Mesoderm Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Regulation Of Actin Filament-based Process Response To Transforming Growth Factor Beta Immune System Process Regulation Of Cartilage Development Protein Serine/threonine Kinase Activity Regulation Of Cellular Component Organization Positive Regulation Of Cell Migration Regulation Of Actin Filament Organization Response To Cholesterol Roof Of Mouth Development Response To Stress Positive Regulation Of Cell Motility Regulation Of Organelle Organization Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation	Ephrin Receptor Signaling Pathway Ephrin Receptor Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Regulation Of Locomotion Regulation Of Cell Adhesion Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Cell Migration Cell Projection Organization Positive Regulation Of Cell Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell Motility Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Plasma Membrane Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Migration Regulation Of Cell Projection Organization Fc Receptor Mediated Stimulatory Signaling Pathway Intracellular Signal Transduction Regulation Of Organelle Organization Fc Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of Cell Motility Cellular Developmental Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Fc-gamma Receptor Signaling Pathway Regulation Of Cell-matrix Adhesion Regulation Of Signal Transduction ERBB Signaling Pathway Regulation Of Endocytosis Positive Regulation Of Immune System Process Regulation Of Cell-substrate Adhesion Regulation Of Signaling Regulation Of Cell Communication Regulation Of Biological Quality Regulation Of Neuron Projection Development Regulation Of Anatomical Structure Morphogenesis Cellular Response To Oxygen-containing Compound Cell Differentiation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Multicellular Organismal Process
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