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ARHGEF6 and CBFA2T3
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
ARHGEF6
CBFA2T3
Description
Rac/Cdc42 guanine nucleotide exchange factor 6
CBFA2/RUNX1 partner transcriptional co-repressor 3
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Cell-cell Junction
Lamellipodium
Cell Projection
Golgi Membrane
Nucleus
Nucleoplasm
Nucleolus
Golgi Apparatus
Membrane
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Protein Binding
Transcription Corepressor Activity
Protein Binding
Zinc Ion Binding
Metal Ion Binding
Biological Process
Apoptotic Process
JNK Cascade
Lamellipodium Assembly
Response To Hypoxia
DNA-templated Transcription
Negative Regulation Of Cell Population Proliferation
Cell Differentiation
Granulocyte Differentiation
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Glycolytic Process
Negative Regulation Of DNA-templated Transcription
Regulation Of Aerobic Respiration
Pathways
NRAGE signals death through JNK
G alpha (12/13) signalling events
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
G beta:gamma signalling through CDC42
CDC42 GTPase cycle
RAC1 GTPase cycle
RHOU GTPase cycle
Drugs
Diseases
Non-syndromic X-linked mental retardation
GWAS
Autism spectrum disorder (
34069769
)
Breast cancer (
29059683
)
Annualised percent change of cerebrospinal fluid AB1-42 levels (
31370031
)
Carotid intima media thickness (
30510157
)
Carotid intima media thickness (mean) (
31801372
)
Emphysema annual change measurement in smokers (percent low attenuation area) (
31324189
)
Hair color (
26926045
)
Hemoglobin levels (
32327693
)
Immature fraction of reticulocytes (
32888494
)
Levodopa-induced dyskinesia in levodopa treated Parkinson's disease (
32733355
)
Lymphocyte percentage of white cells (
32888494
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular volume (
32888494
)
Mean platelet volume (
27863252
32888494
)
Mean reticulocyte volume (
32888494
)
Multiple sclerosis (
31604244
)
Neutrophil count (
32888494
)
Red cell distribution width (
32888494
)
Red vs. brown/black hair color (
30531825
)
Social autistic-like traits (
24133439
)
Vitiligo (
27723757
)
Interacting Genes
36 interacting genes:
ADAM15
ARAP3
ARHGEF7
BMPR1B
CAPNS1
CBFA2T3
CCDC33
CDC42
EPHB2
GIT1
GOLGA2
GPRASP2
HSF2BP
KRT27
NUTM1
PAK1
PAK2
PAK3
PARVB
PNMA1
POU6F2
RWDD2A
SH2D1A
SH3GL3
SIRPA
SMAD1
SMAD2
SMAD3
TGFBR1
TGFBR2
TMEM108
TP53BP2
TRAF2
TRIM54
YWHAG
ZNF580
23 interacting genes:
ARHGEF6
CBFA2T2
CHRM4
DRC4
EPM2AIP1
GATAD2A
GMEB2
HDAC1
HDAC3
MATN2
PIN1
PRKAR2A
RTN4IP1
RUNX1
RUNX1T1
SEC24A
TCF3
VPS37C
ZBTB33
ZBTB38
ZBTB4
ZBTB47
ZNF652
Entrez ID
9459
863
HPRD ID
02226
04847
Ensembl ID
ENSG00000129675
ENSG00000129993
Uniprot IDs
B7Z3C7
Q15052
Q8N4Q3
O75081
PDB IDs
1UJY
1WYR
9DE2
Enriched GO Terms of Interacting Partners
?
Enzyme-linked Receptor Protein Signaling Pathway
Response To Growth Factor
Dendritic Spine Development
I-SMAD Binding
Cellular Response To Growth Factor Stimulus
Regulation Of Cytoskeleton Organization
Regulation Of Supramolecular Fiber Organization
Ephrin Receptor Signaling Pathway
SMAD Protein Signal Transduction
SMAD Protein Complex
Trophoblast Cell Migration
Heteromeric SMAD Protein Complex
Embryonic Cranial Skeleton Morphogenesis
Activin Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Regulation Of Stress Fiber Assembly
Co-SMAD Binding
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Primary MiRNA Processing
Transforming Growth Factor Beta Receptor Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
SMAD Binding
Protein Kinase Binding
Homomeric SMAD Protein Complex
Positive Regulation Of Stress Fiber Assembly
Regulation Of Actin Cytoskeleton Organization
Dendritic Spine Morphogenesis
Positive Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Microtubule Nucleation
Protein Kinase Activity
Positive Regulation Of Actin Filament Bundle Assembly
Cellular Response To Lectin
Stimulatory C-type Lectin Receptor Signaling Pathway
Paraxial Mesoderm Morphogenesis
Transforming Growth Factor Beta Ligand-receptor Complex
Regulation Of Actin Filament-based Process
Response To Transforming Growth Factor Beta
Immune System Process
Regulation Of Cartilage Development
Protein Serine/threonine Kinase Activity
Regulation Of Cellular Component Organization
Positive Regulation Of Cell Migration
Regulation Of Actin Filament Organization
Response To Cholesterol
Roof Of Mouth Development
Response To Stress
Positive Regulation Of Cell Motility
Regulation Of Organelle Organization
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Regulation Of DNA-templated Transcription
Negative Regulation Of DNA-templated Transcription
Regulation Of RNA Metabolic Process
DNA-binding Transcription Factor Binding
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of RNA Biosynthetic Process
Protein Lysine Delactylase Activity
Methyl-CpG Binding
Negative Regulation Of RNA Metabolic Process
Protein Decrotonylase Activity
Histone Decrotonylase Activity
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Transcription Corepressor Binding
DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Histone Deacetylase Activity, Hydrolytic Mechanism
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Zinc Ion Binding
Protein Deacetylation
Protein Lysine Deacetylase Activity
Transcription Corepressor Activity
Nucleoplasm
NuRD Complex
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Negative Regulation Of Myotube Differentiation
Negative Regulation Of Macromolecule Metabolic Process
Histone Deacetylase Activity
Regulation Of Gene Expression
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Fate Specification
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Metabolic Process
Macromolecule Deacylation
NF-kappaB Binding
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Telomere Tethering At Nuclear Periphery
Cis-trans Isomerase Activity
Positive Regulation Of Ferroptosis
Methyl-CpNpG Binding
Regulation Of Metabolic Process
Negative Regulation Of Striated Muscle Cell Differentiation
Histone Deacetylase Complex
Regulation Of Myotube Differentiation
Regulation Of Cell Fate Commitment
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Tagcloud (Difference)
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Tagcloud (Intersection)
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